Study of the influence of sodium taurocholate (STC) and sodium glycocholate (SGC) on the mass transfer of certain drugs. Digoxin

Kassem, M. A.; Mattha, Amir G.; El-Nimr, Atef E.; Omar, S. M.

doi:10.1016/0378-5173(82)90128-4

Cited by 11 publications

(5 citation statements)

References 22 publications

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“…Solubility and WettingsThe effect of bile salt solubilization has been studied for many drugs; for example, griseofulvin, 61-63 danazol, 58 digoxin, 64 diethylstilbestrol, 65 diazepam, 66 halofantrine, 67 leucotriene antagonists, 68 and gemfibrozil. 69 Typically, solubility may increase 0.2-2 orders of magnitude in representative postprandial simple micellar systems compared with buffer control.…”

Section: The Role Of Bile In Drug Dissolution and Solubilizationmentioning

confidence: 99%

Physicochemical and Physiological Mechanisms for the Effects of Food on Drug Absorption: The Role of Lipids and pH

Charman

Porter

Mithani

et al. 1997

Journal of Pharmaceutical Sciences

544

343

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Drugs are absorbed after oral administration as a consequence of a complex array of interactions between the drug, its formulation, and the gastrointestinal (GI) tract. The presence of food within the GI tract impacts significantly on transit profiles, pH, and its solubilization capacity. Consequently, food would be expected to affect the absorption of co-administered drugs when their physicochemical properties are sensitive to these changes. The physicochemical basis by which ingested food/lipids induce changes in the GI tract and influence drug absorption are reviewed. The process of lipid digestion is briefly reviewed and considered in the context of the absorption of poorly water-soluble drugs. The effect of food on GI pH is reviewed in terms of location (stomach, upper and lower small intestine) and the temporal relationship between pH and drug absorption. Case studies are presented in which postprandial changes in bioavailability are rationalized in terms of the sensitivity of the physicochemical properties of the administered drug to the altered GI environment.

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Section: The Role Of Bile In Drug Dissolution and Solubilizationmentioning

confidence: 99%

Physicochemical and Physiological Mechanisms for the Effects of Food on Drug Absorption: The Role of Lipids and pH

Charman

Porter

Mithani

et al. 1997

Journal of Pharmaceutical Sciences

544

343

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“…Small intestinal fluid contains various endogenous surfactants, including bile salts (BS) and phospholipids (PL), which form mixed micelles with high solubilizing capacity for many poorly soluble drugs (1)(2)(3)(4)(5)(6). Human intestinal BS concentrations reported in the literature are dependent on many factors (e.g.…”

Section: Introductionmentioning

confidence: 99%

Colloidal Structures in Media Simulating Intestinal Fed State Conditions with and Without Lipolysis Products

et al. 2008

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“…In this review, the available literature9–71 involving the measurements of the solubilization of drugs and other chemical entities in bile salt solutions has been reviewed. In addition, the data have been classified and a common quantitative basis has been used from which the extent of solubilization was compared.…”

Section: Introductionmentioning

confidence: 99%

Examination of the Solubilization of Drugs by Bile Salt Micelles

Wiedmann

Kamel

2002

Journal of Pharmaceutical Sciences

150

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Study of the influence of sodium taurocholate (STC) and sodium glycocholate (SGC) on the mass transfer of certain drugs. Digoxin

Cited by 11 publications

References 22 publications

Physicochemical and Physiological Mechanisms for the Effects of Food on Drug Absorption: The Role of Lipids and pH

Physicochemical and Physiological Mechanisms for the Effects of Food on Drug Absorption: The Role of Lipids and pH

Colloidal Structures in Media Simulating Intestinal Fed State Conditions with and Without Lipolysis Products

Examination of the Solubilization of Drugs by Bile Salt Micelles

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