Study of the effect on flow rate for planar type polymer-based diaphragm piezoelectric actuated valveless micropump for insulin delivery

Revathi, S.; Padmanabhan, R.

doi:10.1080/2374068x.2016.1147766

Cited by 5 publications

(2 citation statements)

References 12 publications

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“…The check-valved piezoelectric pump uses the position of the valve plate relative to the valve port to control the one-way flow of the liquid, which can achieve a large back pressure and flow [22]. However, its structure becomes complex because of the valve [23], the blockage of the valve is prone to mechanical failure [21], and the fatigue and wear of valve will also reduce the life and reliability [24]. In order to alleviate the fatigue and wear to provide more accurate flow, Zhang et al proposed a piezoelectric diaphragm pump with six one-way valves, which attested the increase of the one-way valve can reduce the backflow effectively, and the fluctuation of back pressure could be significantly suppressed.…”

Section: Introductionmentioning

confidence: 99%

Design and investigation on a novel piezoelectric screw pump

Yin

Zhou

Zhao

et al. 2020

Smart Mater. Struct.

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In order to alleviate the problem of low back pressure of valveless piezoelectric pumps, a novel piezoelectric screw pump was proposed, manufactured and tested. It used the movable cavity formed by screw thread fit to realize liquid transportation. The theoretical model was used to analyze the factors affecting the performance of the piezoelectric screw pump. The geometrical parameters of the piezoelectric vibrator were optimized by the finite element method, and a prototype was made for testing. The test verifies the results calculated by the above analysis. The results showed that under the driving frequency of 13.8 kHz, the maximum back pressure was 6.70 kPa and the maximum flow was 750 µl min −1 . Moreover, this novel piezoelectric screw pump is simple in structure, and can maintain the state of liquid circuit by self-locking when power is off, and has higher reliability.

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Section: Introductionmentioning

confidence: 99%

Design and investigation on a novel piezoelectric screw pump

Yin

Zhou

Zhao

et al. 2020

Smart Mater. Struct.

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“…In recent years, micropumps play an increasingly important role in the field of biological (Elham et al, 2016), medical (Florian et al, 2015; Revathi and Padmanabhan, 2016), chemical (Zhou et al, 2016), electronics cooling (Kim et al, 2012), fuel delivery (Chao et al, 2011; Nisar et al, 2008), and so on. Among the many types of mechanical micropumps, piezoelectric micropump received more and more attention due to some advantages such as simple structure, easy manufacturing, high efficiency, no electromagnetic interference, and good reliability (Ma et al, 2011; Nguyen et al, 2002; Peter, 2005).…”

Section: Introductionmentioning

confidence: 99%

Performance of single piezoelectric vibrator micropump with check valve

Dong

Chen

et al. 2019

Journal of Intelligent Material Systems and Structures

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A new single vibrator piezoelectric micropump which integrated the check valve and the piezoelectric oscillator is designed in this research. The micropump mainly consists of a circular piezoelectric vibrator, a polyethylene terephthalate check valve, two rubber sealing rings, upper pump cover, and lower pump cover. In this research, in order to study output performance of the single vibrator piezoelectric pump, theoretical analysis and experimental verification of the piezoelectric pump check valve have been carried out by exploiting the method of check valves and vibrator mass separation. Experimental results show that the opening of the check valve is mainly caused by the pressure difference and the inertia force. The dominant factor of check valve opening is different under different drive frequencies. A maximum opening displacement of 19.625 μm of the check valve is obtained when the micropump is driven by a sinusoidal voltage of 60 V at 300 Hz. In addition, the maximum flow rate of 2034.7 mL min−1 is obtained when the micropump is driven by a sinusoidal voltage of 60 V at 320 Hz, and a maximum output pressure of 0.82 kPa is obtained when the micropump is driven by a sinusoidal voltage of 60 V at 140 Hz.

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Microfluidic-based systems for the management of diabetes

Zhang,

Staples

2024

Drug Deliv. and Transl. Res.

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Diabetes currently affects approximately 500 million people worldwide and is one of the most common causes of mortality in the United States. To diagnose and monitor diabetes, finger-prick blood glucose testing has long been used as the clinical gold standard. For diabetes treatment, insulin is typically delivered subcutaneously through cannula-based syringes, pens, or pumps in almost all type 1 diabetic (T1D) patients and some type 2 diabetic (T2D) patients. These painful, invasive approaches can cause non-adherence to glucose testing and insulin therapy. To address these problems, researchers have developed miniaturized blood glucose testing devices as well as microfluidic platforms for non-invasive glucose testing through other body fluids. In addition, glycated hemoglobin (HbA1c), insulin levels, and cellular biomechanics-related metrics have also been considered for microfluidic-based diabetes diagnosis. For the treatment of diabetes, insulin has been delivered transdermally through microdevices, mostly through microneedle array-based, minimally invasive injections. Researchers have also developed microfluidic platforms for oral, intraperitoneal, and inhalation-based delivery of insulin. For T2D patients, metformin, glucagon-like peptide 1 (GLP-1), and GLP-1 receptor agonists have also been delivered using microfluidic technologies. Thus far, clinical studies have been widely performed on microfluidic-based diabetes monitoring, especially glucose sensing, yet technologies for the delivery of insulin and other drugs to diabetic patients with microfluidics are still mostly in the preclinical stage. This article provides a concise review of the role of microfluidic devices in the diagnosis and monitoring of diabetes, as well as the delivery of pharmaceuticals to treat diabetes using microfluidic technologies in the recent literature. Graphical abstract

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Study of the effect on flow rate for planar type polymer-based diaphragm piezoelectric actuated valveless micropump for insulin delivery

Cited by 5 publications

References 12 publications

Design and investigation on a novel piezoelectric screw pump

Design and investigation on a novel piezoelectric screw pump

Performance of single piezoelectric vibrator micropump with check valve

Microfluidic-based systems for the management of diabetes

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