Study of the effect of stenosis severity and non-Newtonian viscosity on multidirectional wall shear stress and flow disturbances in the carotid artery using particle image velocimetry

DiCarlo, Amanda; Holdsworth, David W.; Poepping, Tamie L.

doi:10.1016/j.medengphy.2018.12.023

Cited by 29 publications

(19 citation statements)

References 66 publications

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“…Quite similar results are observed in the stenosis throat, Fig. 11 (b), however, although it is not perceptible, the 50% stenotic model presents higher TI values than the healthy model, as it has been also observed by other authors [46], [49]- [51]. Downstream of stenosis, Fig.11 (c), those differences are more notable and the plot of the 70% stenotic model presents a different behavior, with a concavity inward in the central zone, and higher values of TI near the wall.…”

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confidence: 88%

Modeling Blood Pulsatile Turbulent Flow in Stenotic Coronary Arteries

2020

International Journal of Biology and Biomedical Engineering

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Atherosclerosis is a potentially serious illness where arteries become clogged with fatty substances called plaques. Over the years, this pathological condition has been deeply studied and computational fluid dynamics has played an important role in investigating the blood flow behavior. Commonly, the blood flow is assumed to be laminar and a Newtonian fluid. However, under a stenotic condition, the blood behaves as a non-Newtonian fluid and the pulsatile blood flow through coronary arteries could result in a transition from laminar to turbulent flow condition. The present study aims to analyze and compare numerically the blood flow behavior, applying the k-ω SST model and a laminar assumption. The effects of Newtonian and non-Newtonian (Carreau) models were also studied. In addition, the effect of the stenosis degree on velocity fields and wall shear stress based descriptors were evaluated. According to the results, the turbulent model is shown to give a better overall representation of pulsatile flow in stenotic arteries. Regarding, the effect of non-Newtonian modeling, it was found to be more significant in wall shear stress measurements than in velocity profiles. In addition, the appearance of recirculation zones in the 50% stenotic model was observed during systole, and a low TAWSS and high OSI were detected downstream of the stenosis which, in turn, are risk factors for plaque formation. Finally, the turbulence intensity measurements allowed to distinguish regions of recirculating and disturbed flow.

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confidence: 88%

Modeling Blood Pulsatile Turbulent Flow in Stenotic Coronary Arteries

2020

International Journal of Biology and Biomedical Engineering

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“…In another study, the authors analyzed the transitional flow [21] using idealized carotid models. Similar studies were conducted by DiCarlo et al [22,23]. Costa et al [6] used a patient-specific geometry of a coronary artery with a shape similar to the one presented here.…”

Section: Introductionmentioning

confidence: 64%

3D Printed Biomodels for Flow Visualization in Stenotic Vessels: An Experimental and Numerical Study

Carvalho

Rodrigues

Ribeiro³

et al. 2020

Micromachines

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Atherosclerosis is one of the most serious and common forms of cardiovascular disease and a major cause of death and disability worldwide. It is a multifactorial and complex disease that promoted several hemodynamic studies. Although in vivo studies more accurately represent the physiological conditions, in vitro experiments more reliably control several physiological variables and most adequately validate numerical flow studies. Here, a hemodynamic study in idealized stenotic and healthy coronary arteries is presented by applying both numerical and in vitro approaches through computational fluid dynamics simulations and a high-speed video microscopy technique, respectively. By means of stereolithography 3D printing technology, biomodels with three different resolutions were used to perform experimental flow studies. The results showed that the biomodel printed with a resolution of 50 μm was able to most accurately visualize flow due to its lowest roughness values (Ra = 1.8 μm). The flow experimental results showed a qualitatively good agreement with the blood flow numerical data, providing a clear observation of recirculation regions when the diameter reduction reached 60%.

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“…The challenge is that the three-dimensional WSS requires a complete velocity gradient tensor, which did not become achievable in optical experiments until the last decade followed by the developments of the full 3D measurement techniques, such as multi-plane stereoscopic PIV (Stereo-PIV), tomographic PIV (Tomo-PIV) and Shake-the-Box (STB). [5,40,13,4] In the current active research area of fluid mechanics in biomedical applications, there is a shift of focus from single-to multi-modality studies. Integrating data (namely in vivo, in vitro, and in silico datasets) is one of the recommended approaches for validating numerical results and providing comprehensive hemodynamic assessments.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hemodynamic Study of a Patient-Specific Intracranial Aneurysm: Comparative Assessment of Tomographic PIV, Stereoscopic PIV, In Vivo MRI and Computational Fluid Dynamics

Gürzing

Schinkel

et al. 2021

Cardiovasc Eng Tech

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Introduction Wall shear stress (WSS) is associated with the growth and rupture of an intracranial aneurysm. To reveal their underlying connections, many image-based computational fluid dynamics (CFD) studies have been conducted. However, the methodological validations using both in vivo medical imaging and in vitro optical flow measurements were rarely accompanied in such studies. Methods In the present study, we performed a comparative assessment on the hemodynamics of a patient-specific intracranial saccular aneurysm using in vivo 4D Flow MRI, in silico CFD, in vitro stereoscopic and tomographic particle imaging velocimetry (Stereo-PIV and Tomo-PIV) techniques. PIV experiments and CFD were conducted under steady state corresponding to the peak systole of 4D Flow MRI. Results The results showed that all modalities provided similar flow features and overall surface distribution of WSS. However, a large variation in the absolute WSS values was found. 4D Flow MRI estimated a 2- to 4-fold lower peak WSS (3.99 Pa) and a 1.6- to 2-fold lower mean WSS (0.94 Pa) than Tomo-PIV, Stereo-PIV, and CFD. Bland-Altman plots of WSS showed that the differences between PIV-/CFD-based WSS and 4D Flow MRI-based WSS increase with higher WSS magnitude. Such proportional trend was absent in the Bland-Altman comparison of velocity where the resolutions of PIV and CFD datasets were matched to 4D Flow MRI. We also found that because of superior resolution in the out-of-plane direction, WSS estimation by Tomo-PIV was higher than Stereo-PIV. Conclusions Our results indicated that the differences in spatial resolution could be the main contributor to the discrepancies between each modality. The findings of this study suggest that with current techniques, care should be taken when using absolute WSS values to perform a quantitative risk analysis of aneurysm rupture.

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Study of the effect of stenosis severity and non-Newtonian viscosity on multidirectional wall shear stress and flow disturbances in the carotid artery using particle image velocimetry

Cited by 29 publications

References 66 publications

Modeling Blood Pulsatile Turbulent Flow in Stenotic Coronary Arteries

Modeling Blood Pulsatile Turbulent Flow in Stenotic Coronary Arteries

3D Printed Biomodels for Flow Visualization in Stenotic Vessels: An Experimental and Numerical Study

Hemodynamic Study of a Patient-Specific Intracranial Aneurysm: Comparative Assessment of Tomographic PIV, Stereoscopic PIV, In Vivo MRI and Computational Fluid Dynamics

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