Study of the capacity of the essential oil of Lantana montevidensis to modulate the action of fluconazole on Candida albicans and Candida tropicalis strains

Silva, Juliana de Lima; Pereira, Pedro Silvino; Oliveira, Carlos Vinicius Barros; Freitas, Maria Audilene de; Silva, Jailson Renato de Lima; Costa, Adrielle Rodrigues; Oliveira-Tintino, Cícera Datiane de Morais; Braga, Maria Flaviana Bezerra Morais; Duarte, Antônia Eliene; Coutinho, Henrique Douglas Melo; Barros, Luiz Marivando

doi:10.1016/j.mycmed.2021.101171

Cited by 3 publications

(2 citation statements)

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“…Synergistic interactions between antimicrobial agents offer improvements in the efficacy of clinical treatment, the inhibitory concentration of antibacterial agents, the risk associated with the development of bacterial resistance and the reduction of the toxic effect of antifungals to the host. Therefore, the use of associated substances has been widely studied and used as a treatment for infections [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant and Antifungal Activity of the Cynophalla flexuosa (L.) J. Presl (Capparaceae) against Opportunistic Fungal Pathogens

Salazar

Carneiro

Silva

et al. 2022

Future Pharmacology

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The chemical composition of the Cynophalla flexuosa hydroethanolic extract (CFHEE) was identified and its antioxidant, antifungal and antipleomorphic activities against C. albicans and C. tropicalis strains were evaluated. Phytochemical prospecting evidenced polyphenolic and triterpenoid compounds while UPLC-MS analysis revealed the presence of Isopropyl/n-propyl-GLS; Methylpropyl-GLS/butyl-GLS; Methylbutyl-GLS; Quercetin O-di-hexoside; Quercetin-pentosyl-hexoside; Rutin; Quercetin O-glucoside; Kaempferol O-rhamnosyl-hexoside; Kaempferol O-pentosyl-hexoside and Lariciresinol hexoside. The CFHEE inhibited the effect of the DPPH● free radical, both when evaluated individually and in combination with the antifungal fluconazole. When associated with 256 μg/mL fluconazole, the extract, at concentrations from 128 μg/mL, reduced the effect of the DPPH● free radical with values ranging from 37.7% to 95.8%. The extract’s antifungal effect was considered clinically irrelevant and its combination with the antifungal triggered an antagonistic effect against the two strains, thus indicating the popular use of bravo beans in the form of teas or infusions should not be combined with the intake of the drug Fluconazole as this may lead to a reduction of its clinical effect. The extract, however, inhibited morphological changes (pleomorphism) in Candida species, preventing the development of hyphae. The CFHEE possesses an antioxidant effect and a potential pharmacological activity for the inhibition of one of the Candida spp. virulence factors.

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Section: Introductionmentioning

confidence: 99%

“…Such action is responsible for eliminating or reducing free radicals that are formed during metabolic reactions. If not eliminated by enzymes or antioxidant substances, they can cause degenerative diseases of aging and cell death overtime [12][13][14].…”

Section: Introductionmentioning

confidence: 99%