Immunomodulatory responses of differentially polarized macrophages to fungal infections

Xie, Yuxin; Zhou, Xue; Zhang, Jinping; Yu, Hong; Song, Zhimin

doi:10.1016/j.intimp.2022.109089

Cited by 4 publications

(2 citation statements)

References 184 publications

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“…For comprehensive information on macrophage polarization during viral infections, particularly in noncholinergic settings, we highly recommend consulting the insightful reviews authored by Yu et al [30] and Atmeh et al [37]. Likewise, for information concerning macrophage polarization processes during bacterial, fungal, and parasitic infections, please refer to the reviews by Benoit et al [38], Xie et al [39], and Zhang et al [40], respectively.…”

Section: Polarization Of Macrophages During Viral Infectionmentioning

confidence: 99%

Cholinergic Polarization of Human Macrophages

Roa-Vidal,

Rodríguez-Aponte,

Lasalde-Dominicci

et al. 2023

IJMS

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Macrophages serve as vital defenders, protecting the body by exhibiting remarkable cellular adaptability in response to invading pathogens and various stimuli. These cells express nicotinic acetylcholine receptors, with the α7-nAChR being extensively studied due to its involvement in activating the cholinergic anti-inflammatory pathway. Activation of this pathway plays a crucial role in suppressing macrophages’ production of proinflammatory cytokines, thus mitigating excessive inflammation and maintaining host homeostasis. Macrophage polarization, which occurs in response to specific pathogens or insults, is a process that has received limited attention concerning the activation of the cholinergic anti-inflammatory pathway and the contributions of the α7-nAChR in this context. This review aims to present evidence highlighting how the cholinergic constituents in macrophages, led by the α7-nAChR, facilitate the polarization of macrophages towards anti-inflammatory phenotypes. Additionally, we explore the influence of viral infections on macrophage inflammatory phenotypes, taking into account cholinergic mechanisms. We also review the current understanding of macrophage polarization in response to these infections. Finally, we provide insights into the relatively unexplored partial duplication of the α7-nAChR, known as dup α7, which is emerging as a significant factor in macrophage polarization and inflammation scenarios.

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Section: Polarization Of Macrophages During Viral Infectionmentioning

confidence: 99%

Cholinergic Polarization of Human Macrophages

Roa-Vidal,

Rodríguez-Aponte,

Lasalde-Dominicci

et al. 2023

IJMS

View full text Add to dashboard Cite

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“…Invasive pathogens often occur in people with compromised immunity (Xie et al 2022 ). Therefore, antifungal agents could act by either having a direct antifungal (fungicidal or fungistatic) effect on pathogenic fungi or playing a role in upregulating a patient’s immunity (Arastehfar et al 2020 ; Lei et al 2023 , 2022 ).…”

Section: Introductionmentioning

confidence: 99%

The potential role of plant secondary metabolites on antifungal and immunomodulatory effect

Zhou

Zeng

Huang

et al. 2023

Appl Microbiol Biotechnol

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With the widespread use of antibiotic drugs worldwide and the global increase in the number of immunodeficient patients, fungal infections have become a serious threat to global public health security. Moreover, the evolution of fungal resistance to existing antifungal drugs is on the rise. To address these issues, the development of new antifungal drugs or fungal inhibitors needs to be targeted urgently. Plant secondary metabolites are characterized by a wide variety of chemical structures, low price, high availability, high antimicrobial activity, and few side effects. Therefore, plant secondary metabolites may be important resources for the identification and development of novel antifungal drugs. However, there are few studies to summarize those contents. In this review, the antifungal modes of action of plant secondary metabolites toward different types of fungi and fungal infections are covered, as well as highlighting immunomodulatory effects on the human body. This review of the literature should lay the foundation for research into new antifungal drugs and the discovery of new targets. Key points • Immunocompromised patients who are infected the drug-resistant fungi are increasing. • Plant secondary metabolites toward various fungal targets are covered. • Plant secondary metabolites with immunomodulatory effect are verified in vivo.

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