Study of the boron levels in serum after implantation of different ratios nano-hexagonal boron nitride–hydroxy apatite in rat femurs

Atila, Alptuğ; Halıcı, Zekai; Çadırcı, Elif; Karakuş, Emre; Palabıyık, Şaziye Sezin; Ay, Nuran; Bakan, Feray; Yilmaz, Sahin

doi:10.1016/j.msec.2015.09.041

Cited by 27 publications

(15 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…50,54,55 In the context of biological applications, hBN has gained interest due to its lower cytotoxicity compared to its carbon analogues. 56–60 The high biocompatibility of hBN has resulted in a recent surge of studies exploring biomedical technologies based on this material, including drug delivery, fluorescent labeling in cells, and tissue engineering. 61–67 …”

mentioning

confidence: 99%

Assessing and Mitigating the Hazard Potential of Two-Dimensional Materials

Guiney¹,

Wang

Xia

et al. 2018

ACS Nano

View full text Add to dashboard Cite

The family of two-dimensional (2D) materials is comprised of a continually expanding palette of unique compositions and properties with potential applications in electronics, optoelectronics, energy capture and storage, catalysis, and nanomedicine. To accelerate the implementation of 2D materials in widely disseminated technologies, human health and environmental implications need to be addressed. While extensive research has focused on assessing the toxicity and environmental fate of graphene and related carbon nanomaterials, the potential hazards of other 2D materials have only recently begun to be explored. Herein, the toxicity and environmental fate of post-carbon 2D materials, such as transition metal dichalcogenides, hexagonal boron nitride, and black phosphorus, are reviewed as a function of their preparation methods and surface functionalization. Specifically, we delineate how the hazard potential of 2D materials is directly related to structural parameters and physicochemical properties, and how experimental design is critical to the accurate elucidation of the underlying toxicological mechanisms. Finally, a multidisciplinary approach for streamlining the hazard assessment of emerging 2D materials is outlined, thereby providing a pathway for accelerating their safe use in a range of technologically relevant contexts.

show abstract

mentioning

confidence: 99%

Assessing and Mitigating the Hazard Potential of Two-Dimensional Materials

Guiney¹,

Wang

Xia

et al. 2018

ACS Nano

View full text Add to dashboard Cite

show abstract

“…In order to improve the mechanical properties of biomaterials and increase their biocompatibility, h-BN has been used in many studies as a biocomposite component [8,9,36,[48][49][50]59,60]. For example, in one study, it was demonstrated that some particular mechanical properties of HA were improved with the addition of boron nitride nanotubes, and it was reported that there was no negative effect on the viability and proliferation of osteoblast cells [9].…”

Section: Discussionmentioning

confidence: 99%

In vivo biocompatibility and fracture healing of hydroxyapatite-hexagonal boron nitride- chitosan-collagen biocomposite coating in rats

Deveci¹,

Gönenci²,

Canpolat³

et al. 2020

Turk J Vet Anim Sci

View full text Add to dashboard Cite

The biocompatibility of orthopaedic implants and their effects on fracture healing have key roles for success. In this study, it was aimed to investigate the effects of a novel biocomposite consisting of hydroxyapatite (HA), hexagonal boron nitride (h-BN), chitosan (Cs), and type 1 collagen (Ct1) on biocompatibility and fracture healing in rats. A total of 60 adult male Wistar rats weighing 300-500 g were used in the study. The rats were randomly divided into 2 groups named A (uncoated/control) and B (biocomposite coated). Biocomposite (HA/h-BN/Cs/Ct1) coated and uncoated stainless-steel implants were used as intramedullary pins. Groups A and B were divided into subgroups of A1 and B1 (15th day), A2 and B2 (30th day), A3 and B3 (45th day) according to the date of euthanasia. Clinical, radiographic, haematological, biochemical, and histopathological findings were evaluated by pairwise comparisons. The findings were consistent and similar. No statistically significant difference was found for a finding disturbing the biocompatibility. Histopathological examinations showed that coating biomaterials did not resorb over the course of 15, 30, and 45 days. It is thus revealed that the content is biocompatible. However, it has been concluded that it is necessary to increase the physical strength of the coating surface against sterilization and surgical procedures. As a result, based on the interpretations of the clinical, radiographic, haematological, biochemical, and histopathological findings, the biocompatibility of HA/h-BN/Cs/Ct1 biocomposite materials has been revealed.

show abstract

“…All the rats were subjected to specific pathogen free conditions (12 h light/dark cycle, 23 °C) and were provided with food and water. The surgical procedure was carried out in the right femurs sterilely as described before . After the rats were anesthetized with inhaled isoflurane, the surgery region was shaved and sterilized using iodophor.…”

Section: Methodsmentioning

confidence: 99%

Enzymatic Reaction Generates Biomimic Nanominerals with Superior Bioactivity

Jiang

Zhou

Zhu

et al. 2018

Small

View full text Add to dashboard Cite

In vivo mineralization is a multistep process involving mineral‐protein complexes and various metastable compounds in vertebrates. In this complex process, the minerals produced in the mitochondrial matrix play a critical role in initiating extracellular mineralization. However, the functional mechanisms of the mitochondrial minerals are still a mystery. Herein, an in vitro enzymatic reaction strategy is reported for the generation of biomimic amorphous calcium phosphate (EACP) nanominerals by an alkaline phosphatase (ALP)‐catalyzed hydrolysis of adenosine triphosphate (ATP) in a weakly alkalescent aqueous condition (pH 8.0–8.5), which is partially similar to the mitochondrial environment. Significantly, the EACP nanomineral obviously promotes autophagy and osteogenic differentiation of human bone marrow‐derived mesenchymal stem cells by activating an AMPK related pathway, and displays a high performance in promoting bone regeneration. These results provide in vitro evidence for the effect of ATP on the formation and stabilization of the mineral in the mineralization process, demonstrating a potential strategy for the preparation of the biomimic mineral for treating bone related diseases.

show abstract

Study of the boron levels in serum after implantation of different ratios nano-hexagonal boron nitride–hydroxy apatite in rat femurs

Cited by 27 publications

References 43 publications

Assessing and Mitigating the Hazard Potential of Two-Dimensional Materials

Assessing and Mitigating the Hazard Potential of Two-Dimensional Materials

In vivo biocompatibility and fracture healing of hydroxyapatite-hexagonal boron nitride- chitosan-collagen biocomposite coating in rats

Enzymatic Reaction Generates Biomimic Nanominerals with Superior Bioactivity

Contact Info

Product

Resources

About