Study of the adjuvanticity of lysine lipopeptides; carbamate analogs elicit strong Th1 and Th2 response to ovalbumin in mice

Ismail, Tabasum; Shafi, Syed; Gupta, Anand P.; Khajuria, Anamika; Sidiq, Tabasum; Reddy, D. Mahendhar; Alam, Mohammad Sarwar; Qazi, G. N.; Kumar, Halmuthur M. Sampath

doi:10.1016/j.intimp.2011.07.016

Cited by 4 publications

(1 citation statement)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our continuous efforts to develop better immune potentiators, we successfully attempted the synthesis of molecules containing triazoloyl and isooxazoline moieties. The main goal was to synthesize some isoxazolines and triazoles conjugates which can be used to test the synergism between these two heterocylic pharmacopores on the immnomodulation activity of bis ‐heterocycles.…”

Section: Introductionmentioning

confidence: 99%

Design and Synthesis of Novel 1,2,3‐Triazole‐ and 2‐Isoxazoline‐Based Bis‐Heterocycles as Immune Potentiators

Ismail

Shafi

Hyder

et al. 2015

Archiv der Pharmazie

Self Cite

View full text Add to dashboard Cite

A series of novel bis-heterocycles encompassing isoxazolines and triazoles were synthesized through a novel one-pot procedure that involves in situ generation of nitrile oxide and its 1,3-dipolar cycloaddition to variedly substituted acrylates. The synthesized bis-heterocycles (8a-l) were subjected to in vitro lymphocyte proliferation assays followed by in vivo studies of the more active compounds (8g and 8h) to assess their influence on various aspects of the immune system like ex vivo splenocyte proliferation (T- and B-cell proliferation), antibody production (HA titer), delayed-type hypersensitivity reaction, T-cell subtypes (CD4 and CD8), cytokine production (IL-2, IFN-γ, and IL-4), NO (macrophage) production, and toxic effects. The results from the in vitro and in vivo studies establish that the tested compounds 8g and 8h possess excellent immunopotentiating activity.

show abstract

Section: Introductionmentioning

confidence: 99%