Study of serum malondialdehyde levels in chronic renal failure Patients: A hospital based study in Govt. general hospital, Anantapuramu, Andhra Pradesh

Abstract

Chronic Kidney disease is a recognized public health problem with a huge social and economical impact on the individual, family, society and country. Renal failure is a systemic disease and induces a slow and progressive decline of kidney function aggravated by various factors such as diabetes, infections, auto immune diseases and toxic chemicals. The study was aimed to estimate malondialdehyde, urea and creatinine levels in Chronic renal failure (CRF) patients. The study was conducted in the department of Biochemistry, Government medical college, Anantapuramu, Andhra Pradesh. Study subjects were divided in to 2 groups: Group -1: healthy controls (35) with age group 35-65 years, Group -2 : CRF patients (35) age group 35 -65 years . Blood Sample was analyzed for plasma glucose, Blood urea, serum creatinine and serum Malondialdehyde. The mean and standard deviation of Serum Malondialdehyde, blood urea and serum Creatinine in Chronic renal failure patients (Group-2) was higher compared to controls (Group-1) (p<0.0001). Significant positive correlation was observed between serum Malondialdehyde and serum creatinine. A positive correlation was observed between serum Malondialdehyde and blood urea (r= 0.40576). Significant positive correlation existed between Malondialdehyde and serum creatinine (r=0.46832). In our study on chronic renal failure patients and age matched healthy controls, the renal parameters – urea, creatinine and BUN were elevated. In addition Malondialdehyde was found to be significantly elevated showing a pro oxidant status in CRF patients

Protective effect of yacon leaves extract (Smallanthus sonchifolius(Poepp.) H. Rob) through antifibrosis, anti-inflammatory, and antioxidant mechanisms toward diabetic nephropathy

“…By altering the quantity of antioxidant enzymes in kidney cells and producing too many Reactive Oxygen Species (ROS), hyperglycemia results in the induction of oxidative stress ( 15 ). Malondialdehyde (MDA) level could be measured to evaluate the levels of free radicals and oxidative stress ( 16 ).…”