Study of Serum Lipid Profile and Magnesium in Normal Pregnancy and in Pre-Eclampsia: A Case Control Study

Maksane, Shalini; Ranka, Rashmi; Maksane, Nitin; Sharma, Anjali

doi:10.3923/ajb.2011.228.239

Cited by 8 publications

(6 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The significant increase of TGL/HDL ratio in preeclamptic population is shown in figure 4. The dyslipidemia of elevated triglycerides and lowered HDL in our study was similar to that of previous studies (31)(32)(33) .…”

Section: Triglyceride Values In Preeclampsia and Control Group 4: Athsupporting

confidence: 92%

Dyslipidemia in Preeclampsia – Risk Factor for Future Maternal Cardiovascular Diseases

Pushparaj¹,

Subramanyam²

2012

jemds

View full text Add to dashboard Cite

Preeclampsia is still one of the leading causes of maternal and fetal morbidity and mortality. It is associated with insulin resistance & increase in Free Fatty Acids and plasma Triglycerides well above that seen in normal pregnancy. The pattern of dyslipidemia seen in preeclampsia may predispose these women to future cardiovascular diseases. The aim of this study was to compare the alteration in lipid profile and also the calculated risk ratios of women who developed Preeclampsia with normotensive pregnant women. This cross sectional study was carried out in Mahatma Gandhi Memorial Government Hospital, Trichy, Tamilnadu.100 women with preeclampsia and 100 normotensive pregnant women as controls were included in the study after obtaining their informed consent. The diagnosis of Preeclampsia was done as per the norms of American college of Obstetrics and Gynecologists. Fasting blood samples were collected. Serum glucose, cholesterol, triglycerides, and HDL-C were estimated by standard methods using standard kits. LDL-C was calculated by Friedwald's equation. All the results were analyzed statistically using ANOVA technique. There was significant elevation of total cholesterol, triglycerides, LDL, VLDL and risk ratios TC/HDL and TGL/HDL and decrease in HDL in Preeclamptic group compared to normotensives (p<0.0001). The dyslipidemic pattern of elevated TGL and reduced HDL which was also reflected in highly elevated TGL/HDL seen in preeclamptic patients is definitely atherogenic and may lead to future maternal cardiovascular disease. Hence simple measurement of lipid profile at 20 weeks of gestation can help in preventing the complications of PIH and future cardio vascular risk of the mother. Further studies in larger population in various ethnic groups are required to predict maternal future cardiovascular risk and its prevention by lifestyle modifications and therapy.

show abstract

Section: Triglyceride Values In Preeclampsia and Control Group 4: Athsupporting

confidence: 92%

Dyslipidemia in Preeclampsia – Risk Factor for Future Maternal Cardiovascular Diseases

Pushparaj¹,

Subramanyam²

2012

jemds

View full text Add to dashboard Cite

show abstract

“…similar results were obtained by Garg D K et al (20), Sandip et al (21) and Lambe et al (23). Reduced extracellular magnesium induces partial membrane depolarization and reduced repolarization, as well as the opening of membrane calcium channels, resulting influx of calcium intracellularly.Low serum magnesium is also said to increase endothelin-1-mediated smooth muscle contraction and inhibit the release of prostacyclin from the endothelial cells of the umbilical arteries, resulting in an increase in blood pressure (24).…”

Section: Resultsmentioning

confidence: 99%

Comparative Study of Serum Calcium, Magnesium, Uric Acid and Glucose in Preeclampsia and Normal Pregnant Women of Malwa Region of Madhya Pradesh

Jain

Kulmi

Paliwal

et al. 2021

IJMBS

View full text Add to dashboard Cite

Background: Comparative study of serum calcium, magnesium, uric acid and glucose in preeclampsia and normal pregnant women of malwa region of Madhya pradesh Methods: For the Study, a total of 100 women ranging in age from 18-35 years were recruited. They were divided in two groups. 50 were pre-eclamptic women with gestational age of ?20 weeks (Case group) and rest 50 were normal pregnant women of same gestational age (Control group).The levels of magnesium, calcium, glucose, and uric acid in the blood were measured. Result: Serum calcium and magnesium levels were significantly lower (p<0.001) in the pre-eclamptic group, whereas serum uric acid levels were significantly higher (p0<001) in preeclamptic group. The level of serum glucose was raised in preeclampsia. Conclusion: serum levels of calcium, magnesium, uric acid and glucose are altered in pre-eclampsia, implying that these factors may play a role in the aetiology and severity of pre-eclampsia.so assessing the serum level of this parameters will aid in the early detection of pre-eclampsia. Keywords: Calcium, Magnesium, Uric acid, Glucose, Pre-eclampsia, Pregnancy

show abstract

“…This may cause increased delivery of free fatty acids for biosynthesis of endogenous triglycerides in liver. (12) Lowering of lipoprotein lipase in normal pregnancy may be another reason for increase in serum TG levels. (13) Insulin resistance and hyperinsulinaemia found in pregnancy may also be responsible for the hypertriglyceridaemia in normal pregnancy.…”

Section: Discussionmentioning

confidence: 99%

“…(17) The increase in HDL in normotensive pregnant women can be explained by hyperoestrogenaemia. (12) In preeclampsia, the oestrogen level decreases, so reduced HDL may be due to hypooestrogenaemia. The decrease in HDL may also be due to exaggerated insulin resistance seen in preeclampsia.…”

Section: Discussionmentioning

confidence: 99%

A Tertiary Care Centre Based Study on Serum Lipid Levels in Healthy Non-Pregnant Women, Normal Pregnancy and in Preeclampsia

S¹,

Maliekkal²,

Geetha³

et al. 2018

jemds

View full text Add to dashboard Cite

BACKGROUND Preeclampsia is more prevalent in the first pregnancy and is associated with very high maternal and foetal morbidity and mortality. Although, the exact cause of preeclampsia is still unknown, the basic pathology lies in the endothelial cell dysfunction and intense vasospasm. Dyslipidaemia is believed to play a key role in altering the microenvironment around endothelium. So, the objective is to study the serum lipid levels in healthy non-pregnant women, normal pregnancy and in preeclampsia. MATERIALS AND METHODS Fasting serum lipid levels were estimated in 40 healthy non-pregnant women (Group-1), 40 normotensive primigravida (Group-2) and in 40 preeclamptic primigravida in their third trimester (Group-3). Serum lipid levels were estimated using fully automated analyser. Data was analysed using SPSS Version 18 software. P value < 0.05 was considered as statistically significant. RESULTS Compared with normal pregnancy, in preeclampsia, the level of serum total cholesterol, triglycerides, VLDL and LDL were significantly increased and HDL was decreased significantly. In normal pregnant women, serum total cholesterol, triglycerides, HDL, VLDL and LDL levels were significantly high compared to healthy non-pregnant women. CONCLUSION Dyslipidaemia in pregnancy may be associated with increased risk of developing preeclampsia. Screening of the above parameters may help in developing strategies for prevention and better management of preeclampsia.

show abstract

Study of Serum Lipid Profile and Magnesium in Normal Pregnancy and in Pre-Eclampsia: A Case Control Study

Cited by 8 publications

References 10 publications

Dyslipidemia in Preeclampsia – Risk Factor for Future Maternal Cardiovascular Diseases

Dyslipidemia in Preeclampsia – Risk Factor for Future Maternal Cardiovascular Diseases

Comparative Study of Serum Calcium, Magnesium, Uric Acid and Glucose in Preeclampsia and Normal Pregnant Women of Malwa Region of Madhya Pradesh

A Tertiary Care Centre Based Study on Serum Lipid Levels in Healthy Non-Pregnant Women, Normal Pregnancy and in Preeclampsia

Contact Info

Product

Resources

About