Study of N‐vinylpyrrolidone‐N‐vinylformamide copolymers labelled with indium‐113m

Abstract

The procedure of the directed synthesis of N-vinylpyrrolidone-N-vinylformamide (VP-VFA) copolymers with grafted iminodiacetate (IDA) chelating units is presented. The methods for labelling resulting conjugates with indium-113m were developed. The metal-copolymer conjugates were characterized by different physicochemical methods, including IR and NMR, viscometry, light scattering, and exclusion high-performance liquid chromatography. Parameters of radiochemical synthesis of the conjugates labelled with indium-113m were optimized. It was shown that the VP-VFA-IDA copolymer firmly binds indium-113m both in the acid and alkaline solutions, with pH of the reaction mixture having almost no effect on the complexation. VP-VFA-IDA-In conjugates were found to be unstable in histidine challenge reaction.

Metal-Polymer Complexes of Gallium/Gallium-68 with Copolymers of N-Vinylpyrrolidonewith N-Vinylformamideand N-Vinyliminodiacetic Acid: A Hint for Radiolabeling of Water-Soluble Synthetic Flexible Chain Macromolecules

“…In our previous works [31], we have obtained metal-polymer complexes containing indium or radioactive indium-113m and ternary copolymer VP-VFA-VIDA; hydrodynamic characteristics of the complex were virtually similar to those of the initial copolymer carrier. However, the complexes turned out to be unstable in the reaction of interligand exchange with histidine.…”

Mixed-ligand gallium complexes with N-vinylpyrrolidone- N-vinylformamide-N-vinyliminodiacetic acid terpolymers containing dithiocarbamates as a coligand

“…Синтез тройных сополимеров ВА-ВФА-ВИДУК осуществляли в три стадии по описанным ранее методикам [8,11]. Сначала проводили радикальную сополимеризацию N-винилформамида с N-винилпирролидоном с использованием динитрила азобисизомасляной кислоты (ДАК) в качестве инициатора.…”

“…Недавно [8] нами были получены металл-полимерные комплексы (МПК) индия и радиоактивного индия-113m на основе тройного сополимера N-винилпирролидона (ВП) и N-винилформамида (ВФА) с N-винилиминодиуксусной кислотой (ВИДУК). Эти комплексы практически не меняли своих гидродинамических характеристик по сравнению с полимером-предшественником.…”

Synthesis of Water-Soluble Copolymers of N-vinylpyrrolidone with N-vinyldithiocarbamate as Multidentate Polymeric Chelation Systems and Their Complexes with Indium and Gallium

“…It has been demonstrated previously [ 50 , 51 , 52 ] that VP–VA and VP–AA copolymers containing chelation units (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), iminodiacetic acid (IDA)) have different complexating abilities toward indium and gallium ions. In the cases of VP–VA–DOTA and VP–VA–IDA copolymers, radiochemical yields with gallium-68 were up to 57–66% and 80%, respectively.…”

“…Thus, it could be assumed that compact low denticity ligand systems (IDA), attached to polymeric backbone, have advantages in comparison to bulky chelators, which essentially are oriented to the external surface of polymeric coil. Polymers containing low denticity chelation units can form intramolecular MPC, where metal ion acts as an anchor and have completely occupied the coordination environment [ 52 , 53 , 54 ].…”