Synthesis of Water-Soluble Copolymers of N-vinylpyrrolidone with N-vinyldithiocarbamate as Multidentate Polymeric Chelation Systems and Their Complexes with Indium and Gallium

Abstract

Dithiocarbamate (DTC) derivatives of N-vinylpyrrolidone-N-vinylamine (VP–VA) copolymers were synthesized via reaction between the copolymers and carbon disulfide in alkaline medium; molecular masses of the products were 12 and 29 kDa; the VP:VDTC ratios were 94:6 and 83:17 mol.%. Complexation between the obtained DTC derivatives and metal ions (indium and gallium) was investigated. It was demonstrated that metal–DTC ligand complexes with 1:3 ratio between components were formed. Gallium metal–polymer complexes (MPC) were unstable in solution. Individual indium MPC were isolated and characterized by spectral and chromatographic methods. Unlike similar gallium MPC, they appeared to be stable in histidine challenge reaction.

Environmentally Sensitive Vinylpyrrolidone/methacrylic Acid Inter-complex Amphoteric Hydrogel: Preparation, Characterization, and Use in the Binding of Copper Ions

“…To investigate the complex formation [22] between vinyl pyrrolidone and methacrylic acid, the UV spectra of the aqueous solutions of the monomer and co-monomer, and their 1:1 mixture were taken and presented in Figure 1. While the λmax values for N-vinyl pyrrolidone, methacrylic acid, and the mixture were found to be 288 nm, 290 nm, and 286 nm, respectively, the A values of these solutions were found to be 1.69, 2.06, and 1.45 in the same order.…”

Synthesis, characterization and in vitro cytotoxicity of gallium(iii)-dithiocarbamate complexes

“…With gallium(III) they usually form stable mononuclear homoleptic complexes of the type [Ga(DTC) 3 ], characterized by a GaS 6 core with a trigonal prismatic or triple-helix symmetry rather than an octahedral one, due to the small bite angle of the CS 2 group, though heteroleptic complexes have also been described. 34,[52][53][54][55][56][57][58][59][60][61][62] Nonetheless, the pharmaceutical properties of Ga-DTC complexes are poorly explored. Recently, the biocidal activity of some DTC complexes has been reported; 63 however, to the best of our knowledge, the anticancer activity of this class of compounds has never been explored so far.…”