Study of quality in fish and shellfish as food. IV. Levels of oxolinic acid in cultured yellowtail after oral administration.

Ueno, Ryuji; Horiguchi, Yoshishige; Kubota, Saburoh S.

doi:10.2331/suisan.54.479

Cited by 20 publications

(6 citation statements)

References 2 publications

(2 reference statements)

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“…Formaldehyde residues measured in gilthead seabream fillets after completion of immersion were similar to those considered as control values. These results are in agreement with the findings of other studies revealing that the dose and duration of formalin treatment did not affect the accumulation of formaldehyde residues in the fillet of the studied species (Ueno et al, 1984;Xu & Rogers, 1993;Xu & Rogers, 1995). These findings confirm that the formaldehyde levels in fish fillets recorded herein are close to the natural values measured in untreated fish, as the specific substance is a metabolic product of living organisms and is also necessary for the biosynthesis of specific amino acids (Jung et al, 2001).…”

Section: Discussionsupporting

confidence: 93%

Preliminary measurements of formaldehyde in seawater and edible tissues of farmed gilthead seabream after formalin immersion

et al. 2023

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This study was performed to measure the possible persistence of formaldehyde, the active substance of formalin solution, in seawater and edible gilthead seabream (Sparus aurata) tissues after a formalin bath. The trial was carried out during the summer period as parasitic infestations are of a high frequency. Water samples were taken within or at a short distance from the treatment cages, during and following formalin immersion. Fish fillets were also sampled at the same sampling points. Chromatographic analysis of water and tissue samples was performed with a photodiode array detector (HPLC-PDA). Measured formaldehyde concentrations in gilthead seabream fillets clearly showed no increase due to the immersion or advent of time. Formaldehyde measurements in seawater revealed that after formalin treatments negligible amounts of the substance remain in the aquatic environment and these values seem to be relatively unaffected by depth in the vicinity of the fish cages. Further research is required to investigate the formalin degradation cycle under Mediterranean seawater conditions, including more farm sites and temperature ranges.

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Section: Discussionsupporting

confidence: 93%

Preliminary measurements of formaldehyde in seawater and edible tissues of farmed gilthead seabream after formalin immersion

et al. 2023

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“…Consequently, oxolinic acid is particulary efficient against devastating diseases such as Yersiniosis and Vibriosis (Rodgers & Austin, 1983;Gogny et al, 1990). Many studies on oxolinic acid residues have been published on a variety of fish (Kasuga et al, 1984;Archimbault et al, 1988;Ueno et al, 1988a;Ueno et al, 1988b;Jacobsen, 1989;Ishida, 1990;Steffenak et al, 1991;Ishida, 1992). Other studies are available on the pharmacokinetics of oxolinic acid after a bolus intravascular injection, mostly in salmonid fish (BjoÈ rklund & Bylund, 1991;Rogstad et al, 1993;Martinsen & Horsberg, 1995).…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of oxolinic acid in sea‐bass, Dicentrarchus labrax (L., 1758), after a single rapid intravascular injection

Poher¹,

Blanc²,

Loussouarn³

1997

Vet Pharm & Therapeutics

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The pharmacokinetics of oxolinic acid was studied in sea-bass (Dicentrarchus labrax). The fish were kept in seawater at 15.2 degrees C with a 12 h/12 h photoperiod. Oxolinic acid was injected in the caudal vein of anaesthetized sea-bass in a single rapid intravascular administration at a dose of 10 mg/kg of body weight. Plasma concentrations of oxolinic acid were determined using two analytical methods, a classic plate diffusion bioassay using Escherichia coli and a high performance liquid chromatography (HPLC) using solid phase extraction with an internal standard and a U.V. detection. The mean recoveries were 99.6% and 110.8% and determination limits were 0.04 microg/mL and 0.02 microg/mL, for the bioassay and the HPLC respectively. Compared to other fish species, the oxolinic acid was rapidly (absorption half life, t(a1/2) = 0.69 h) distributed to body tissues outside the blood volume (volume of central compartment, Vc = 0.4 L/kg) and presented a large volume of distribution (Vdss = 2.55 L/kg). Considering its disappearance from the central compartment (rate constant: central-eliminated, k10 = 0.16 h[-1]) and its total body clearance (Cl[t] = 0.066 L/kg x h), the elimination phase of the oxolinic acid in sea-bass was shorter than in trout kept in freshwater, and longer than in salmon in seawater. Consequently, the area under the concentration-time curve (AUC = 157 microg x h/mL) and the mean residence time (MRT = 42 h) were relatively low and short, respectively.

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“…Although there was no information concerning the further metabolism of OXO in sparids, previous rainbow trout and yellowtail studies have demonstrated that glucuronide (OXO-G) was found to be the major metabolite of OXO. Glucuronidation is therefore thought to be the most important stage of the metabolic pathway for OXO in fish (Ishida, 1992;Ueno et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Depletion Study of Oxolinic Acid in Freshwater Softshell Turtle (Pelodiscus sinensis) with Multiple-Dose Oral Administration

Chou

Kuo

Wang

et al. 2019

Israeli Journal of Aquaculture - Bamidgeh

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All drugs used in aquaculture must be approved by the government agency responsible for veterinary medicine; prudent use of antibiotics under veterinary supervision is critical in ensuring safety of aquaculture products. The international production of farmed turtle, considered a cultured aquatic species, has been growing continuously but control of bacteria proliferation in turtle farms requires frequent use of antimicrobials. In the present investigation, the residue depletion and withdrawal period of quinolone antibacterial oxolinic acid (OXO) was evaluated in Chinese softshell turtle Pelodiscus sinensis, after repeated (once daily for 5 days) oral doses of medicated feed containing OXO, at the dose of 30 and 60 mg/kg body weight (bw). Muscle and liver tissues were collected at 1

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Study of quality in fish and shellfish as food. IV. Levels of oxolinic acid in cultured yellowtail after oral administration.

Cited by 20 publications

References 2 publications

Preliminary measurements of formaldehyde in seawater and edible tissues of farmed gilthead seabream after formalin immersion

Preliminary measurements of formaldehyde in seawater and edible tissues of farmed gilthead seabream after formalin immersion

Pharmacokinetics of oxolinic acid in sea‐bass, Dicentrarchus labrax (L., 1758), after a single rapid intravascular injection

Depletion Study of Oxolinic Acid in Freshwater Softshell Turtle (Pelodiscus sinensis) with Multiple-Dose Oral Administration

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