Study of Prevalence of Hepatitis C Virus (HCV) Infection in a Patients attending Tertiary Care Hospital Valsad, Gujarat, India

Patel, Parimal H; Patel, Hiral; Nerurkar, Alka

doi:10.20546/ijcmas.2017.605.312

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…Similar studies showed HCV infection patients had a history of hematological disorders attending hematology OPD and requiring multiple blood transfusion [10]. About 15% of patients [10,15]. HCV, HBV, and HIV all three infections together were also seen in 1.84% of cases in our study.…”

Section: Discussionsupporting

confidence: 86%

Estimation of Prevalence of Hepatitis C Virus Infection by Serological Test and Real Time Rt-PCR Test Among Suspected Viral Hepatitis Cases Attending Tertiary Care Hospital, Kolkata

ASIS KUMAR GHOSH,

RAJA RAY,

KALIDAS RIT

et al. 2023

Asian J Pharm Clin Res

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Objective: Hepatitis C virus (HCV) infection is a major public health problem in India and worldwide. Majority remain asymptomatic until they develop serious complications like liver cirrhosis or hepatocellular carcinoma with fatal outcome. Hence, early diagnosis of active HCV infection and prompt initiation of treatment is important. Treatment with directly acting antivirals (DAAs) resulted in high sustained virological response (SVR) rates of >95% globally. This study was done to estimate seroprevalence and prevalence of active HCV infection among study population. After initiation of treatment, SVR rates were estimated. Methods: This was hospital-based, cross-sectional, and observational study. Screening was done by third-generation Enzyme-linked immunosorbent assay to detect anti-HCV antibody, then confirmatory real-time reverse transcription-polymerase chain reaction (RT-PCR) test was done for detection of active cases and determining their viral load. Treatment of 12-week duration was initiated by DAAs and followed up to estimate SVR by doing real-time RT-PCR after 12 weeks of treatment completion. Result: Among 17,752 consecutive non-repetitive blood samples, seroprevalence was 1.78%. The prevalence of active cases was 1.52%. HCV active infection was prevalent more among male (64.21%) and among 40–60 years age group. History of multiple blood transfusion (58%) was the most common risk factor, followed by multiple sex partners (13.3%). Coinfections with Hepatitis B virus and Human immunodeficiency virus were seen in 13.65% of cases. About 92% of patients completed their treatment. SVR was 97.87%. Conclusion: High SVR of 97.87% is evidence-based data that support that proper treatment can eliminate HCV infection. Detection by real-time RT-PCR and highly effective DAA has made a paradigm shift to approach of HCV diagnosis and management in recent times

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Section: Discussionsupporting

confidence: 86%

Estimation of Prevalence of Hepatitis C Virus Infection by Serological Test and Real Time Rt-PCR Test Among Suspected Viral Hepatitis Cases Attending Tertiary Care Hospital, Kolkata

ASIS KUMAR GHOSH,

RAJA RAY,

KALIDAS RIT

et al. 2023

Asian J Pharm Clin Res

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“…In India, overall prevalence of HCV is reported to be 0.19-0.68% in various hospital based studies. [6][7][8][9][10] One systemic review found prevalence of HCV (anti-HCV) to be 0.85% in community-based studies, 0.44% in blood donors and 0.88% among pregnant women in India. 3 In our study, the prevalence of HCV infection is 0.05% overall and 0.02% among pregnant women.…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of hepatitis C virus among patients at a tertiary health care centre in Rajasthan, India

et al. 2020

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Background: To ascertain the prevalence of Hepatitis C infection among patients visiting a tertiary care center in Jaipur, Rajasthan.Methods: An observation analytic study was done at a tertiary care center affiliated to Medical College with retrospective analysis of the hospital data of two calendar years. During this period HCV infection screening (anti-HCV) was offered to every suspected patient admitted in hospital and every pregnant women visiting antenatal care clinic.Results: The study prevalence of HCV infection was 0.05% (13/25311). The prevalence was more in female (0.03%) than male (0.02%). The study prevalence of anti-HCV among pregnant female was 0.02% (3/16224). Maximum positive cases (4/13, 30.77% positive cases) were in the age group of 21-30 years (sexually active group) and >50 years age group while minimum positivity was found in children (00 case, 0-20 years age).Conclusions: In this study, prevalence of HCV infection was 0.05%. The study prevalence of HCV among pregnant females was 0.02%. Maximum positive cases (4/13, 30.77% positive cases) were in the age group of >50 years and 21-30 years. This study aids in view to strengthen proper screening for HCV infection to reduce HCV related morbidity and mortality

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Study of Prevalence of Hepatitis C Virus (HCV) Infection in a Patients attending Tertiary Care Hospital Valsad, Gujarat, India

Cited by 2 publications

References 11 publications

Estimation of Prevalence of Hepatitis C Virus Infection by Serological Test and Real Time Rt-PCR Test Among Suspected Viral Hepatitis Cases Attending Tertiary Care Hospital, Kolkata

Estimation of Prevalence of Hepatitis C Virus Infection by Serological Test and Real Time Rt-PCR Test Among Suspected Viral Hepatitis Cases Attending Tertiary Care Hospital, Kolkata

Seroprevalence of hepatitis C virus among patients at a tertiary health care centre in Rajasthan, India

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