Study of potential drug-drug interaction between prescribed drugs in patients attending outpatient department of medicine at tertiary-care hospital in south Gujarat region

Chavda, Nilesh; Solanky, Priti; Baria, Hinal; Naik, Ruchi; Bharti, Komal

doi:10.5455/njppp.2015.5.0508201428

Cited by 13 publications

(12 citation statements)

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“…We found moderate and major-pDDIs mostly, while, concerning scientific evidence, fair and good type. Our results are consistent with results of a study conducted among outpatients [ 17 ]. Similarly, studies among hospitalized patients also indicate similar results [ 7 , 10 , 27 ].…”

Section: Discussionsupporting

confidence: 93%

Potential drug-drug interactions in outpatient department of a tertiary care hospital in Pakistan: a cross-sectional study

Ismail

Noor

Harram

et al. 2018

BMC Health Serv Res

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BackgroundPotential drug–drug interactions (pDDIs) are one of the preventable drug related problems having the risk of serious adverse events or therapeutic failure. In developing countries like Pakistan, this issue remains poorly addressed. The objective of this study was to explore prevalence of pDDIs in the Outpatient Department (OPD) of a tertiary care hospital in Pakistan. The secondary aim was to describe the levels of reported pDDIs and develop a list of widespread clinically relevant interactions.MethodsPrescriptions of 2400 OPD patients were analyzed for pDDIs through Micromedex Drug-Reax®. Prevalence, severity- and documentation-levels and widespread clinically relevant interactions were reported.ResultsOf total 2400 prescriptions, pDDIs were present in 22.3%. Whereas, moderate- and major-pDDIs were found in 377 (15.7%) and 225 (9.4%), respectively. PDDIs were more prevalent in Medicine (9.2%) and Cardiology (2.6%) as compared with other OPD specialties. Total 942 pDDIs were identified, of which, the majority were either moderate- (61.9%) or major-pDDIs (32.1%). Some of the most common interactions were ibuprofen + levofloxacin (n = 50), ciprofloxacin + diclofenac (32), aspirin + atenolol (24), and diclofenac + levofloxacin (19). The potential adverse outcomes of widespread interactions were seizures, bleeding, QT-interval prolongation, arrhythmias, tendon rupture, hypoglycemia/hyperglycemia, serotonin syndrome, drug toxicity, and decreased therapeutic response.ConclusionsOPD patients were at risk to pDDIs, particularly to major- and moderate-pDDIs. Screening of prescriptions for pDDIs and monitoring of pharmacotherapy in terms of response and associated adverse drug events will contribute to patient safety.Electronic supplementary materialThe online version of this article (10.1186/s12913-018-3579-7) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 93%

Potential drug-drug interactions in outpatient department of a tertiary care hospital in Pakistan: a cross-sectional study

Ismail

Noor

Harram

et al. 2018

BMC Health Serv Res

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“…The DIs may cause significant morbidity in patients and economic burden on healthcare system. 3 Aging is associated with physiological changes that may alter absorption, distribution, metabolism and excretion and response to drug. 4 Geriatric population may suffer from more than one pathological condition necessitating prescription of more than one drug.…”

Section: Introductionmentioning

confidence: 99%

Study of potential drug interactions between prescribed drugs in geriatric patients attending outpatient department in a government tertiary care hospital in Maharashtra

Nishandar

Kale

Pise

2016

Int J Basic Clin Pharmacol

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“…(Fig. 3) [16]. From 163 pharmacokinetics pDDIs, 45.41% were altered the absorption, 28.99% were altered the metabolism, and 25.60% were altered the excretion.…”

Section: Ramalingam Et Almentioning

confidence: 98%

“…Of the 215 pharmacodynamic pDDIs, 67.44% were synergistic, 30.70% antagonistic, and 1.86% unknown in nature. The reason for the majority being pharmacodynamic interaction is that these types of interactions derive from modification of the action of one drug at the target site by another drug, independent of a change in its [16]. From pDDIs detected in the study by Chavda et al, the majority were of pharmacodynamic (58.83%) in nature, followed by pharmacokinetics (38.53%) interactions [16].…”

Section: Ramalingam Et Almentioning

confidence: 99%

“…The reason for the majority being pharmacodynamic interaction is that these types of interactions derive from modification of the action of one drug at the target site by another drug, independent of a change in its [16]. From pDDIs detected in the study by Chavda et al, the majority were of pharmacodynamic (58.83%) in nature, followed by pharmacokinetics (38.53%) interactions [16]. These findings are in contrast to the study reported by Vonbach et al [17] and Aparasu et al, wherein, it was reported that 76% of pharmacokinetics and 22% of pharmacodynamic interactions (Fig.…”

Section: Ramalingam Et Almentioning

confidence: 99%

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Assessment of Potential Drug Interactions Among Hospitalized Patients at the Cardiac and Pulmonary Departments in Tertiary Care Hospitals

Ramalingam

Rajagopal²,

Kandasamy

et al. 2018

Asian J Pharm Clin Res

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Objective: The aim of this study was to assess the potential drug interactions among hospitalized patients in cardiac and pulmonary wards in three tertiary care hospitals. Methods:A prospective, observational study was carried out for 12 months. A sample of 1150 patients were assessed for potential drug-drug interactions (pDDIs) using Micromedex ® -2.7 and Drugs.com. Results:A total of 1150 patients were analyzed, and it was found that 685 were cardiac and 465 were pulmonary patients. The study identified 524 (76.49%) cardiac patients and 345 (74.19%) pulmonary patients, with pDDIs higher in male cardiac (298 [56.87%]) and male pulmonary (199 [57.68%]) patients, compared to females. Incidences of pDDIs were found to be higher in the age group of 60-70 years in cardiac (193 [36.83%]) and pulmonary (146 [42.31%]) patients and incidences of interactions based on duration of 4-6 days' hospital stays in cardiac were 380 (72.53%) and 215 (62.31%) in pulmonary patients, respectively. Moreover, 51.90% of cardiac patients and 56.52% of pulmonary patients were found to be prescribed with more number of drugs (cardiac 7 drugs and pulmonary 5-6 drugs) causing higher incidences of pDDIs. Some of the most common drug interacting pair was aspirin and clopidogrel combination observed in 245 cardiac patients, whereas in the pulmonary department, it was ranitidine-theophylline combination with a frequency of 195 pDDIs. Drug-food interactions were found with atorvastatin-citrus fruits in cardiac and theophylline-caffeine in pulmonary patients. The most common drug-disease interaction was found to be isosorbide dinitrate-myocardial infarction in cardiac and diazepam-COPD in pulmonary, respectively. Conclusion:Pharmacists must take responsibility in the monitoring of drug interactions and notifying the physician and patient about potential problems. With their detailed knowledge of drugs, pharmacists have the ability to relate unexpected symptoms experienced by patients to possible adverse effects of their drug therapy.

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Study of potential drug-drug interaction between prescribed drugs in patients attending outpatient department of medicine at tertiary-care hospital in south Gujarat region

Cited by 13 publications

References 0 publications

Potential drug-drug interactions in outpatient department of a tertiary care hospital in Pakistan: a cross-sectional study

Potential drug-drug interactions in outpatient department of a tertiary care hospital in Pakistan: a cross-sectional study

Study of potential drug interactions between prescribed drugs in geriatric patients attending outpatient department in a government tertiary care hospital in Maharashtra

Assessment of Potential Drug Interactions Among Hospitalized Patients at the Cardiac and Pulmonary Departments in Tertiary Care Hospitals

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