Study of Platelet Diameter Distribution in Patients with Valvular Heart Disease and with Prosthetic Heart Valve Replacement

Dumoulin, M; Tirmarche, M.; Horellou, M.H.; Acar, J; Samama, M

doi:10.1159/000214384

Cited by 4 publications

(3 citation statements)

References 1 publication

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“…These results suggest that dogs with cardiac murmurs have altered platelet function. This is in contrast to some initial reports in the human medical literature in which patients with valvular cardiac disease had platelets in an activated state as defined by increased platelet diameter 20 and increased numbers of spread‐type platelets 21 . However, studies to date in dogs have supported the finding of decreased platelet function in cardiac disease.…”

Section: Discussioncontrasting

confidence: 84%

“…Cardiac disease has the potential to alter platelet function in humans and dogs, but there is conflicting information as to whether hypofunction or hyperfunction is present. In earlier studies in humans with cardiac disease, platelets were noted to be in an activated state 20,21 . The few studies reported in dogs have instead supported platelet hypofunction in cardiac disease 1–5 .…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of platelet function in dogs with cardiac disease using the PFA‐100 platelet function analyzer

Clancey

Burton

Horney

et al. 2009

Veterinary Clinical Pathol

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Background: Cardiac disease has the potential to alter platelet function in dogs. Evaluation of platelet function using the PFA-100 analyzer in dogs of multiple breeds and with a broad range of cardiac conditions would help clarify the effect of cardiac disease on platelets. Objectives: The objective of this study was to assess differences in closure time (CT) in dogs with cardiac disease associated with murmurs, when compared with that of healthy dogs. Methods: Thirty-nine dogs with cardiac murmurs and turbulent blood flow as determined echocardiographically were included in the study. The dogs represented 23 different breeds. Dogs with murmurs were further divided into those with atrioventricular valvular insufficiency (n = 23) and subaortic stenosis (n = 9). Fifty-eight clinically healthy dogs were used as controls. CTs were determined in duplicate on a PFA-100 analyzer using collagen/ ADP cartridges. Results: Compared with CTs in the control group (mean AE SD, 57.6 AE 5.9 seconds; median, 56.5 seconds; reference interval, 48.0-77.0 seconds), dogs with valvular insufficiency (mean AE SD, 81.9 AE 26.3 seconds; median, 78.0 seconds; range, 52.5-187 seconds), subaortic stenosis (71.4 AE 16.5 seconds; median, 66.0 seconds; range, 51.5-95.0 seconds), and all dogs with murmurs combined (79.6 AE 24.1 seconds; median, 74.0 seconds; range, 48.0-187 seconds) had significantly prolonged CTs (P o.01). Conclusions: The PFA-100 analyzer is useful in detecting platelet function defects in dogs with cardiac murmurs, most notably those caused by mitral and/or tricuspid valvular insufficiency or subaortic stenosis. The form of turbulent blood flow does not appear to be an important factor in platelet hypofunction in these forms of cardiac disease.

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Section: Discussioncontrasting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Evaluation of platelet function in dogs with cardiac disease using the PFA‐100 platelet function analyzer

Clancey

Burton

Horney

et al. 2009

Veterinary Clinical Pathol

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“…4 Platelet dysfunction with MR has been reported. 5,6 In a morphology study of valvular heart disease, platelets became larger than 2.9 m in diameter 7 and spread-type platelets (hyperactive platelets) were increased. 8 Platelet life span in humans with mitral valve disease has been measured by radioisotope methods.…”

mentioning

confidence: 99%

Changes in Platelet Life Span in Dogs with Mitral Valve Regurgitation

et al. 2002

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Platelet life span was measured in dogs with experimentally-induced mitral regurgitation (MR) by using an in vitro whole-blood biotinylation technique to evaluate the effects of shear stress induced by MR. Mitral regurgitation was created in healthy dogs by ablation of the mitral valve chordae tendineae. Mitral regurgitation was identified by auscultation and postoperative color Doppler echocardiography. Platelets were biotinylated, and derivatized blood was reinfused into the dogs. Biotinylated platelet disappearance was measured over time to determine platelet life span. Pre-and postablation platelet life span was compared in each dog. Platelet life span was shorter in dogs with experimentally induced MR. Shear stress from MR was postulated to shorten platelet life span. Alternations in platelet function and life span may contribute to the progression of cardiovascular disease in dogs with MR. Further studies are required to determine if platelet dysfunction is related to disease progression in these patients.

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Platelet Size In Health and Hematologic Disease

Bessman

Williams

Gilmer

1982

American Journal of Clinical Pathology

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In normal subjects, mean platelet volume (MPV) has an inverse, nonlinear relation with platelet count, while platelet volume heterogeneity has a direct, nonlinear relation with MPV. Compared with the reference range established for normal subjects, patients with chronic lymphocytic leukemia, atherosclerotic heart disease, diabetes mellitus, and chronic undifferentiated schizophrenia had normal platelet volume mean and heterogeneity. Patients treated with cytotoxic chemotherapy for acute nonlymphocytic leukemia, patients with megaloblastic anemia, and patients with aplastic anemia had abnormally small platelets with increased heterogeneity. Patients with chronic myelogenous leukemia had abnormally large platelets with increased heterogeneity.

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Study of Platelet Diameter Distribution in Patients with Valvular Heart Disease and with Prosthetic Heart Valve Replacement

Cited by 4 publications

References 1 publication

Evaluation of platelet function in dogs with cardiac disease using the PFA‐100 platelet function analyzer

Evaluation of platelet function in dogs with cardiac disease using the PFA‐100 platelet function analyzer

Changes in Platelet Life Span in Dogs with Mitral Valve Regurgitation

Platelet Size In Health and Hematologic Disease

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