Study of Parameters for Evaluating the Pushability of Interventional Devices Using Box-shaped Blood Vessel Biomodels Made of PVA-H or Silicone

Abstract

In this paper, we investigated several parameters with effect on the compressive force to assess the mechanical properties of interventional device. We find several parameters are highly influential and others are not. In our evaluation system, we prepared a box-shaped PVA-H and silicone with realistic geometry and carried out the measurement and evaluation of the pushability by using load cell machine. The parameters of velocity, position of device in the system do not affect the compressive force, whereas the length of catheter from the tip to fixed point is one of the most influential parameters for the force. Several behaviors such as passing through the curve or slip and stop can be observed and defined using this system. The balance of the bending force and the pushing force may make the tip with behavior of slip and stop or passing thorough the curve. The investigation of the evaluation system confirmed that high reproducibility with short error bar is indicated. The observation with movie record is also an advantage of our system because the high transparency of materials with silicone and PVA-H can check the inside of artery.

Bioinspired In Vitro Brain Vasculature Model for Nanomedicine Testing Based on Decellularized Spinach Leaves

“…17,18 Some of the models are quite simple and represent just a small part of vessel bifurcation or bend to study particular properties of a developed device. 19 These models share common disadvantageous features: they are large-scale, complex, and, therefore, expensive. Their complexity is associated with the reproduction of bends and changes in the diameter of the vessels.…”

“…Another opportunity for drug and device testing is large-scale vascular models usually simulating large arteries or veins with a diameter up to 1 cm and replicating complex vessel architecture for soft robots movement control . In some studies, the systems used are an exact copy of a specific section of the body’s vasculature. , Some of the models are quite simple and represent just a small part of vessel bifurcation or bend to study particular properties of a developed device . These models share common disadvantageous features: they are large-scale, complex, and, therefore, expensive.…”