Study of occurrence of risk factors of metabolic syndrome in women with PCOS

Abstract

PCOS is one of the most common endocrine disorders of women in the reproductive age group. Metabolic syndrome is one of the major health issues currently to be focused on in young age group. To identify women with PCOS at risk of developing the metabolic syndrome and the association of individual metabolic parameters with PCOS. A prospective observational study done in 132 non pregnant women aged 18-35 years diagnosed with PCOS using Rotterdam’s criteria. Metabolic syndrome was diagnosed according to AHA/NHLBI (ATP III 2005) definition. Fisher’s exact test and unpaired t test were applied for statistical analysis. Out of 132 women with PCOS, 31 met the criteria for Metabolic syndrome (23. 5%) and 69.7% women had at least one risk factor out of the five criteria of Metabolic syndrome. Among those meeting criteria for MBS, the mean waist circumference (≥80cms) and mean BMI was found higher (p0.01), and USGmorphology of PCOSp0.05) than those who did not. Presence of acanthosis, SBP/DBP(130/85mmHg), FBS(≥110mg/dl), TG(≥150mg/dl), HDL(≤50mg/dl) were found in significantly greater number in those who met the criteria for MBS as compared to those who did not. Women diagnosed with PCOS and also having features of increased BMI, WC (≥88cms), acanthosis are important risk factors for association of PCOS with Metabolic syndrome in significantly higher numbers and it is important to initiate screening for the same.