When mechanized sub-horizontal section top coal caving (SSTCC) is used as an underground mining method for exploiting extremely steep and thick coal seams (ESTCS), a large-scale surrounding rock caving may be violently created and have the potential to induce asymmetric destabilization from mine voids. In this study, a methodology for assessing the destabilization was developed to simulate the Weihuliang coal mine in the Urumchi coal field, China. Coal-rock mass and geological structure characterization were integrated with rock mechanics testing for assessment of the methodology and factors influencing asymmetric destabilization. The porous rock-like composite material ensured accuracy for building a 3D geological physical model of mechanized SSTCC by combining multi-mean timely track monitoring including acoustic emission, crack optical acquirement, roof separation observation, and close-field photogrammetry. An asymmetric 3D modeling analysis for destabilization characteristics was completed. Data from the simulated hydraulic support and buried pressure sensor provided effective information that was linked with stress-strain relationship of the working face in ESTCS. The results of the 3D physical model experiments combined with hybrid statistical methods were effective for predicting dynamic hazards in ESTCS.