Study of microencapsulation and controlled release of modified chitosan microparticles containing vitamin B12

Carlan, Ioana C.; Estevinho, Berta N.; Rocha, Fernando

doi:10.1016/j.powtec.2017.05.041

Cited by 54 publications

(27 citation statements)

References 43 publications

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“…Iannone et al (2017) evaluated the production yield of grape seed extract-loaded chitosan micro-particles with different concentration of extract in the system and obtained values between 42.3 and 64.8 %. In general, the results obtained for yield production were considered in overall good agreement with reported values on previous studies on chitosan microparticles for different drug delivery systems, namely 12-48 % for tea polyphenol-Zn complex (Zhang & Zhao, 2015), 24-84 % for vancomycin (Cerchiara et al, 2015), 30-46 % for antituberculotic drugs (Oliveira et al, 2017) and 33-58 % for vitamin B12 (Carlan, Estevinho, & Rocha, 2017).…”

Section: Production Yield Of Microparticlessupporting

confidence: 89%

Iron-rich chitosan-pectin colloidal microparticles laden with ora-pro-nobis (Pereskia aculeata Miller) extract

et al. 2020

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Iron deficiency represents a global nutrition gap that calls for innovative strategies including food fortification, while overcoming the drawbacks of taste and reactivity of iron. The aim of this work was to develop iron-rich colloidal microparticles laden with a Brazilian plant food extract from ora-pro-nobis (OPN, Pereskia aculeata Miller). We formulated electrostatic self-assembled complexes of oppositely charged chitosans and pectin laden with aqueous OPN extract. After characterisation of the physical properties, selected formulations were examined in their colloidal stability (50 mM NaCl, Dulbecco's modified eagle medium (DMEM), simulated gastric fluid (SGF) and simulated intestinal fluid (SIF)), production yield, iron association efficiency, transmission electron microscopy (TEM), cellular cytotoxicity and iron uptake using Caco-2 cells. The -potential varied from ~-25 mV to ~ +23 mV regardless of the degree of acetylation (DA) of chitosan. The production yield ranged between 20-26 %. The particles were stable at DMEM, SGF and SIF during 3 h. Iron association efficiency was ~60 % for systems charge ratio (n+/n-) = 5.00. TEM analyses revealed invariably spherical morphology. OPN-laden microparticles did not present cytotoxicity against Caco-2 cells. Higher cellular ferritin levels were determined for the particles comprising OPN extract and n+/n-= 5.00. We obtained in vitro proof of concept of the efficiency of chitosan/pectin particles to delivering iron from a Brazilian edible plant extract. The industrial potential of this approach as a viable alternative for iron fortification or supplementation by the food industry is yet to be realised.

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Section: Production Yield Of Microparticlessupporting

confidence: 89%

Iron-rich chitosan-pectin colloidal microparticles laden with ora-pro-nobis (Pereskia aculeata Miller) extract

et al. 2020

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“…Among the many available controlled release systems, the successful use of polymer microparticles has been reported in the literature in distinct biomedical applications . Microparticles are characterized by characteristic sizes ranging from 1 to 1000 µm and can be applied in the form of microspheres or microcapsules: while microspheres are constituted by compact polymer matrixes (which may contain a dispersed drug), microcapsules are constituted by a rigid polymer wall that surrounds a core of distinct composition (where the drug is usually present)…”

Section: Introductionmentioning

confidence: 99%

Development of Smart Polymer Microparticles through Suspension Polymerization for Treatment of Schistosomiasis

Paiva

Alves

Melo

et al. 2019

Macro Reaction Engineering

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Schistosomiasis is a parasitic disease that affects millions of people, especially low‐income people, and is considered a major public health problem in underdeveloped countries. The drug used most often for the treatment of the disease is praziquantel (PZQ), which has a strong and characteristic bitter taste that makes treatment of children inconvenient. For this reason, the present work investigates the development of smart pH‐sensitive polymer microparticles produced through suspension polymerizations to be used as vehicles for the controlled release of praziquantel in the body. The microparticles are produced through copolymerization of methyl methacrylate and the cationic comonomers diethylaminoethyl methacrylate or dimethylaminoethyl methacrylate. The obtained results indicate that microparticles with sizes in the range of 10–1100 µm can be formed successfully, allowing high PZQ encapsulation efficiencies (>80%). Zeta potential analyses and drug release assays confirm the pH‐sensitive responses of the cationic copolymers, leading to effective release of PZQ (around 80% in pH 1.2) in acidic media that simulate the organic fluids present in the stomach.

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“…Este método, ha sido utilizado en la protección de flavonoides (Shaaruddin et al, 2017), antioxidantes (Araujo-Díaz et al, 2017;Saikia et al, 2015), probióticos (Chaikham et al, 2017), vitaminas (Carlan et al, 2017) y enzimas (Díaz-Martínez et al, 2016).…”

Section: Introductionunclassified

Efecto de la Encapsulación en Secado por Atomización de Biocomponentes de Pitahaya Amarilla con Interés Funcional

et al. 2017

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* Autor a quien debe ser dirigida la correspondenciaRecibido Ene. 26, 2017; Aceptado Mar. 20, 2017; Versión final Jun. 12, 2017, Publicado Dic. 2017 Resumen La pitahaya amarilla contiene biocomponentes como los polifenoles cuya capacidad antioxidante podría causar un efecto fisiológico más allá del nutricional. Sin embargo, estos biocomponentes son sensibles a condiciones ambientales, de procesamiento, y/o gastrointestinales cuando son consumidos. Por ello, fueron sometidos a encapsulación mediante secado por atomización para evaluar el efecto que tiene dicha técnica sobre su conservación. Los resultados mostraron que el tratamiento con mayor efecto fue el realizado a una temperatura de 150 °C con 40% de maltodextrina, logrando prolongar la estabilidad hasta 72 horas para polifenoles totales y 240 horas para la capacidad antioxidante. Con esto se garantiza que la liberación de estos se realice en el intestino delgado, lugar donde quedan disponibles para que el organismo los adsorba. Palabras clave: encapsulación; secado por atomización; sustancias bioactivas; biodisponibilidad Encapsulation Effect on Spray Drying of Yellow Pitahaya Biocomponents of Functional Interest AbstractYellow pitahaya contains biocomponents such as polyphenols with antioxidant capacity that may cause a physiological effect besides the nutritional aspects. However, these biocomponents are sensible to environmental conditions, processing, and/or gastrointestinal environment when they are consumed. Therefore, biocomponents were subjected to encapsulation by spray drying to evaluate the effect of this technique on their conservation. The results show that the most effective treatment was that performed at temperature of 150 °C with 40% maltodextrin, achieving longer stability of up to 72 hours for total polyphenols and 240 hours for the antioxidant capacity. In this way, it is guaranteed that release of these biocomponents will occur in the small intestine, where they are available for the body to adsorb them.

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Study of microencapsulation and controlled release of modified chitosan microparticles containing vitamin B12

Cited by 54 publications

References 43 publications

Iron-rich chitosan-pectin colloidal microparticles laden with ora-pro-nobis (Pereskia aculeata Miller) extract

Iron-rich chitosan-pectin colloidal microparticles laden with ora-pro-nobis (Pereskia aculeata Miller) extract

Development of Smart Polymer Microparticles through Suspension Polymerization for Treatment of Schistosomiasis

Efecto de la Encapsulación en Secado por Atomización de Biocomponentes de Pitahaya Amarilla con Interés Funcional

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