Study of metal dithiocarbamate complexes, Part V. Metal complexes of [S2CN(CH2CH(OMe)2]: A standard dimeric zinc dithiocarbamate structural motive, a rare cadmium dithiocarbamate coordination polymer, and a hydrated sodium dithiocarbarmate complex, with a[Na2O2] core and chain

Ferreira, Isabella P.; Lima, Geraldo Μ. de; Paniago, Eucler B.; Pinheiro, Carlos B.; Wardell, Jámes L.; Wardell, Solange M. S. V.

doi:10.1016/j.ica.2015.11.011

Cited by 32 publications

(15 citation statements)

References 38 publications

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“…Several of the motifs adopted by the binary cadmium(II) dithiocarbamates, 101-141 [98,, are closely related to those observed for their zinc counterparts. Over and above these, are several unprecedented polymeric structures.…”

Section: Cadmium Dithiocarbamatesmentioning

confidence: 74%

“…This arrangement allows for the formation of two-dimensional arrays reminiscent of motif R, and an exemplar, Cd[S 2 CN(Benzyl)CH 2 (3-py)] 2 } n (130) [133], is illustrated in Figure 12c. The distinctive feature in the seven crystals of 135-141 [98,128,129,131,136] is that each of the dithiocarbamate ligands adopts a μ2κ 3 -coordination mode, leading to octahedral S6 coordination geometries and one-dimensional chains. Five of the structures feature 2-fold symmetry with the cadmium atom located on the axis, whereas the chains are propagated by crystallographic inversion symmetry in the remaining two structures.…”

Section: Cadmium Dithiocarbamatesmentioning

confidence: 99%

“…The chains found in 136 [129] and 141 [128], that is, adopting motifs S and T, respectively, are supramolecular isomers [137], suggesting relatively small energy differences between the motifs. Further, solutions of each of 136 and 141 converted over time, within hours, into the dimeric motif O, that is, into 118 [128] and The distinctive feature in the seven crystals of 135-141 [98,128,129,131,136] is that each of the dithiocarbamate ligands adopts a µ 2 κ 3 -coordination mode, leading to octahedral S 6 coordination geometries and one-dimensional chains. Five of the structures feature 2-fold symmetry with the cadmium atom located on the axis, whereas the chains are propagated by crystallographic inversion symmetry in the remaining two structures.…”

Section: Cadmium Dithiocarbamatesmentioning

confidence: 99%

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Exploring the Topological Landscape Exhibited by Binary Zinc-triad 1,1-dithiolates

Tiekink

2018

Crystals

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Abstract:The crystal chemistry of the zinc-triad binary 1,1-dithiolates, that is, compounds of xanthate [ − S 2 COR], dithiophosphate [ − S 2 P(OR) 2 ], and dithiocarbamate [ − S 2 CNR 2 ] ligands, is reviewed. Owing to a wide range of coordination modes that can be adopted by 1,1-dithiolate anions, such as monodentate, chelating, µ 2 -bridging, µ 3 -bridging, etc., there exists a rich diversity in supramolecular assemblies for these compounds, including examples of zero-, one-, and two-dimensional architectures. While there are similarities in structural motifs across the series of 1,1-dithiolate ligands, specific architectures are sometimes found, depending on the metal centre and/or on the 1,1-dithiolate ligand. Further, an influence of steric bulk upon supramolecular aggregation is apparent. Thus, bulky R groups generally preclude the close approach of molecules in order to reduce steric hindrance and therefore, lead to lower dimensional aggregation patterns. The ligating ability of the 1,1-dithiolate ligands also proves crucial in determining the extent of supramolecular aggregation, in particular for dithiocarbamate species where the relatively greater chelating ability of this ligand reduces the Lewis acidity of the zinc-triad element, which thereby reduces its ability to significantly expand its coordination number. Often, the functionalisation of the organic substituents in the 1,1-dithiolate ligands, for example, by incorporating pyridyl groups, can lead to different supramolecular association patterns. Herein, the diverse assemblies of supramolecular architectures are classified and compared. In all, 27 structurally distinct motifs have been identified.

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Section: Cadmium Dithiocarbamatesmentioning

confidence: 74%

Section: Cadmium Dithiocarbamatesmentioning

confidence: 99%

Section: Cadmium Dithiocarbamatesmentioning

confidence: 99%

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Exploring the Topological Landscape Exhibited by Binary Zinc-triad 1,1-dithiolates

Tiekink

2018

Crystals

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“…Many anticancer properties of Disulfiram have been demonstrated in different pre-clinical models of breast, prostate, myeloma, leukemia, lung cancers, cervical adenocarcinoma, melanoma, neuroblastoma and colorectal cancer [3–6, 8–13, 20–25] (Fig. 6).…”

Section: Biochemical Targets For Anticancer Activitymentioning

confidence: 99%

Recent Advances in Antabuse (Disulfiram): The Importance of its Metal-binding Ability to its Anticancer Activity

Viola-Rhenals

Patel

Jaimes-Santamaria

et al. 2018

CMC

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“…The use of appropriate ligands can significantly increase the activity of complex compounds in inhibiting cancer cells 9 . This study used a dithiocarbamate ligands.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Cytotoxic Activity of Zn(ii) Cysteine Dithiocarbamate in Breast Cancer (Mcf-7)

Irfandi¹,

Prihantono²,

Raya³

2019

Int. Res. J. Pharm.

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To synthesize and characterize complex compound of Zn(II) with cysteine dithiocarbamate ligands and studies its cytotoxic activity in breast cancer (MCF-7). The complex of Zn(II) cysteine dithiocarbamate was prepared by "in situ method" and characterized by using Ultraviolet-Visible (UV-Vis) and Infra-Red (IR) spectroscopy, melting point and conductivity. The results of UV-Vis maximum spectrums of Zn(II)cysteine dithiocarbamate at 282 nm and 374 nm indicated that electronic transition π→π* dan n→π* of CS2 and N=C=S. While the presence of IR spectra at the wavelength in the region of 397-534 cm-1 indicated that has been coordination occurred between Zn(II) with Sulphur (S), Nitrogen (N) and Oxygen(O) atoms from cysteine dithiocarbamate ligands. Complex characterization using UV-Vis and IR showed that complex Zn(II) cysteine dithiocarbamate compounds were successfully synthesized by the in-situ method. The results of the cytotoxicity assay of Zn(II) cysteine dithiocarbamate complex compounds in MCF-7 cells obtained IC50 values of Zn(II) complex = 98.60 μg/mL and cisplatin (IC50 = 200 μg/mL. These result can be seen that IC50 value of Zn(II) complex is lower than cisplatin so that Zn(II) complex has very good inhibitory activity against MCF-7 cancer cells compared to cisplatin and it can even cause apoptosis in cancer cells.

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Study of metal dithiocarbamate complexes, Part V. Metal complexes of [S2CN(CH2CH(OMe)2]: A standard dimeric zinc dithiocarbamate structural motive, a rare cadmium dithiocarbamate coordination polymer, and a hydrated sodium dithiocarbarmate complex, with a[Na2O2] core and chain

Cited by 32 publications

References 38 publications

Exploring the Topological Landscape Exhibited by Binary Zinc-triad 1,1-dithiolates

Exploring the Topological Landscape Exhibited by Binary Zinc-triad 1,1-dithiolates

Recent Advances in Antabuse (Disulfiram): The Importance of its Metal-binding Ability to its Anticancer Activity

Synthesis, Characterization and Cytotoxic Activity of Zn(ii) Cysteine Dithiocarbamate in Breast Cancer (Mcf-7)

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