Study of Male Sex Hormone Levels in Male Egyptian Children and Adolescents with End Stage Renal Disease under Regular Haemodialysis

Abstract

IntroductionIn ESRD, gonadal hormones undergo several pathological changes which result in retardation of pubertal development [1]. These hormonal disturbances result in failure to thrive and delay the pubertal development [2]. About one third of male adolescents with CRF has a delayed puberty. Many pathophysiological mechanisms can explain pubertal delay in these patients [1] including hormonal disturbance in the hypothalamohypophyseal gonadal axis, toxic effects of uremia on peripheral tissues, testicular injury and disordered secretion and function of follicular stimulating hormone (FSH) and luteizing hormone (LH) which is known also as interstitial cell stimulating hormone (ICSH) secretion [3]. Study of Male Sex Hormone Levels in Male Egyptian Children and Adolescents with End Stage Renal Disease under Regular HaemodialysisAbstract Background: Delayed puberty is a common pathological finding in male children with chronic renal failure (CRF) secondary the pathological changes in testosterone hormone.