Study of kidney dysfunction in non-silicotic Egyptian workers

Ibrahim, K.; Ahmed, Safia; Amer, Nagat M.

doi:10.1016/j.ijheh.2010.08.012

Cited by 10 publications

(8 citation statements)

References 28 publications

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“…15 These findings were in line with those of other investigators who report that crystalline silica exposure results in an elevation of urinary proteins a r t i c l e among silica-exposed industrial workers. 2,3,16,17 The significant elevation of urinary ALP, g-GT, and LDH among silica-exposed group compared to their controls suggested renal tubular affection and agreed with the results of previous studies that report significantly increased biomarkers for renal proximal tubular dysfunction such as urinary retinol-binding protein (RBP) and urinary N-acetyl-β-D-glucosaminidase (NAG) among silica-exposed industrial workers. 2,18,19 More recent studies used the same urinary enzymes (ALP, g-GT, and LDH) to detect early signs of subclinical nephropathic tubular effect among silicaexposed workers 3 and among patients with diabetes.…”

Section: Discussionsupporting

confidence: 87%

Demonstration of Subclinical Early Nephrotoxicity Induced by Occupational Exposure to Silica among Workers in Pottery Industry

Mourad

Ashour

2020

Int J Occup Environ Med

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Background: For many years, several studies drew attention to the possible nephrotoxic effects of silica and distinct renal dysfunction involving glomerular and renal tubules in workers exposed to silica. Objective: To determine the early signs of subclinical nephrotoxic effects among some Egyptian workers exposed to silica in the pottery industry. Methods: This study was carried out in El-Fawakhir handicraft pottery area, in Greater Cairo, Egypt. The studied population included 29 non-smoking male workers occupationally exposed to silica in addition to 35 non-smoking administrative male subjects who represented the comparison group in the study. Measured urinary parameters were concentrations of total protein (TP), microalbumin (Malb), activities of alkaline phosphatase (ALP), g-glutamyl transferase (g-GT), lactate dehydrogenase (LDH), kidney injury molecule-1 (KIM-1), and silicon (Si). Results: Silica-exposed workers showed significantly (p<0.05) increased levels of urinary TP, Malb, ALP, g-GT, LDH, and KIM-1 compared with the comparison group. Among the silicaexposed group, increased urinary Si levels were positively and significantly correlated (Spearman's ρ>0.60, p<0.001 for all variables) with the elevated urinary proteins (including KIM-1) and enzymes levels. All measured urinary parameters were positively and significantly correlated (ρ>0.75, p<0.001 for all variables) with the duration of work among exposed subjects. No significant correlation was observed between the measured variables and the age of workers. Conclusion: There is associated subclinical glomerular and tubular affection among silicaexposed workers, which is related to the duration and intensity of exposure.

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Section: Discussionsupporting

confidence: 87%

Demonstration of Subclinical Early Nephrotoxicity Induced by Occupational Exposure to Silica among Workers in Pottery Industry

Mourad

Ashour

2020

Int J Occup Environ Med

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“…This might be due to differences in sample size and nature of dust exposure. Studies done by Ng et al, 13 Boujemaa et al, 14 El-Safty et al, 15 and Ibrahim et al 16 also observed proteinuria with a significant rise in urinary albumin among the workers exposed to silica dust, and these findings are also supported by our study results.…”

Section: Discussionsupporting

confidence: 92%

Asymptomatic Renal Function Abnormalities in Patients having Silicosis

Dixit¹

2022

JAPI

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Background: A number of occupational exposures are associated with various types of renal dysfunction. Several studies for many years have drawn attention to renal dysfunction and nephrotoxicity among workers exposed to silica. This study was conducted to evaluate renal dysfunction, if any, among Indian patients having silicosis and its correlation with the duration of exposure to silica dust. Materials and methods: This study includes 52 eligible patients with a history of silica dust exposure and silicosis confirm on radiological examination by the pneumoconiosis board. Investigations like serum creatinine, urinary albumin creatinine ratio, etc. were done. The “modification of diet in renal disease” (MDRD) formula was used to calculate the glomerular filtration rate (GFR). Results: This study showed 53.84% of patients (n = 28) having albuminuria and a mean “urinary albumin to creatinine ratio” (UACR) of 101.88 ± 128.99 mg/gm. Isolated macroalbuminuria was detected in 11.5% of patients (n = 6) while 42.3% of patients (n = 22) presented with microalbuminuria. The mean GFR was 81.94 ± 22.09 mL/min/1.73 m2 among study patients of which four (7.7%) patients had GFR value <60 mL/min/1.73 m2 . We could also identify a significant association between the duration of exposure to silica dust and UACR and GFR (p < 0.01). Conclusion: Albuminuria and reduced estimated GFR in patients with silica dust exposure is not uncommon and reflect early underlying renal dysfunctions. Our study suggests a simple and cost-effective screening strategy for early detection of renal dysfunction among silicosis patients that may be considered as a tool to prevent further renal damage in such patients.

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“…Despite the worldwide diffusion of IgA nephropathy and several reports stating renal function alteration and high prevalence of IgA nephropathy in subjects exposed to silica dusts, we found only two other similar reports, but only one published in English-written medical journal 10 , 11 , 12 , 13 ) . Moreover, the recent retrospective study of Vacek et al.…”

Section: Discussioncontrasting

confidence: 53%

“…However, several elements from this case report may suggest a different interpretation. On the one hand, the cumulative smoking exposure of our patient was relatively low in order to explain per se both pulmonary and renal involvement 13 ) . On the other hand, previous reports suggest a parallel disease progression, where control of glomerulonephritis relapses would be associated with a better prognosis of lung disease 10 , 11 , 12 , 13 ) .…”

Section: Discussionmentioning

confidence: 77%

Silicosis and renal disease: insights from a case of IgA nephropathy

2016

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A 68-yr-old male, smoker, is admitted for proteinuria (2,800 mg/24 h) and reduced renal function (serum creatinine 2 mg/dl, GFR 35 ml/min). Renter, he started working 20-yr-old as a sandstone cave miner. Despite the high levels of silica dusts, he reported no mandatory use of airways protection devices during the first 25 yr of activity. No clinical or radiological signs of silicosis or pneumoconiosis where reported until the year of retirement (1997). Erythrocyte sedimentation rate (91 mm/h) and C reactive protein (35 mg/l) suggested a pro-inflammatory status. High serum IgA was found (465 mg/dl). A renal biopsy identified glomerular sclerosis with IgA deposition, signs of diffuse vasculitis and tubular atrophia suggesting a diagnosis of IgA nephropathy. Chest X-Rays showed emphysema and diffuse nodularity suggesting diagnosis of silicosis. Chest tomography was also positive for mild signs of silicosis with silicotic nodules and without honeycombing. IgA nephropathy is the most common type of glomerulonephritis worldwide. Several clues suggest a genetic or acquired abnormality of immune system as a trigger of the increased production of IgA. In our case report, simultaneous kidney and pulmonary disease could suggest same triggers (e.g. exposure to virus, bacteria or environmental agents) inducing IgA synthesis and pulmonary immune system activation.

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Study of kidney dysfunction in non-silicotic Egyptian workers

Cited by 10 publications

References 28 publications

Demonstration of Subclinical Early Nephrotoxicity Induced by Occupational Exposure to Silica among Workers in Pottery Industry

Demonstration of Subclinical Early Nephrotoxicity Induced by Occupational Exposure to Silica among Workers in Pottery Industry

Asymptomatic Renal Function Abnormalities in Patients having Silicosis

Silicosis and renal disease: insights from a case of IgA nephropathy

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