Silicosis and renal disease: insights from a case of IgA nephropathy

Riccò, Matteo; Thai, Elena; Cella, Simone

doi:10.2486/indhealth.2014-0161

Cited by 8 publications

(3 citation statements)

References 11 publications

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“…With extended exposure, the GFR will progressively decline. Rapidly progressive forms of nephropathy have also been described (Riccò et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Predictive value of novel biomarkers for chronic kidney disease among workers occupationally exposed to silica

2021

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There is a pressing need to find reliable biomarkers for the early diagnosis of silica-induced nephropathy. Abundant genes are upregulated in damaged kidneys with subsequent protein products appearing in the urine. Liver-type fatty acid-binding protein (L-FABP) and kidney injury molecule-1 (KIM-1) are among the most promising. Our objective was to study the importance of L-FABP and KIM-1 genes and their urinary proteins in the early detection of silica-induced renal injury, as compared with other conventional biomarkers. A cross-sectional study was conducted among 90 pottery workers occupationally exposed to silica, as compared to 90 controls. A full history taking and complete clinical examination were performed. Levels of serum creatinine, liver enzymes, urinary silicon, KIM-1, and L-FABP gene expression and protein products were measured. Estimated glomerular filtration rate (eGFR) was calculated, and abdominal ultrasound was performed. The results showed that the silica-exposed group had a statistically significant increase in serum creatinine and urinary silica, as well as a significant decrease in eGFR. Additionally, a significant increase in KIM-1 and L-FABP gene expression, associated with a significant increase in their urinary protein, was found among the exposed group. A positive correlation between urinary silica level and L-FABP gene expression was also found. A receiver operating characteristic curve analysis for L-FABP and KIM-1 gene as predictors for silica-induced nephropathy showed that L-FABP gene and protein specificity were greater than the KIM-1 gene and protein. Taken together, these findings suggest that the L-FABP gene and its protein product may be used as early indicators for renal injury among silica exposed workers.

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“…With extended exposure, the GFR will progressively decline. Rapidly progressive forms of nephropathy have also been described (Riccò et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Predictive value of novel biomarkers for chronic kidney disease among workers occupationally exposed to silica

2021

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“…10 Only a few similar cases were described in the literature. [2][3][4][5][6] A summary of all cases reported has been presented in Table 1.…”

Section: Revised Amendments From Versionmentioning

confidence: 99%

“…However, silicosis-IgA N is a rare association and very few cases have been reported in the literature. [2][3][4][5][6] The underlying pathophysiology remains to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

Case Report: Silicosis and IgA nephropathy, an exceptional association

et al. 2022

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A 57-year-old male who had been working in masonry for 33 years was hospitalized for renal function decline associated with exertional dyspnea. He presented with hypertension and limb edema. Urinalysis revealed an active urine sediment with glomerular proteinuria at 1.5 g/24h and the renal biopsy identified mesangial IgA Nephropathy. Chest tomography scans showed signs of silicosis. The patient received Angiotensin-Converting Enzyme Inhibitors with stable renal function. To our knowledge, the association of silicosis-IgA nephropathy has rarely been reported in the literature. This case highlights the effect of chronic exposure to silica dust and its association with both silica and renal disease.

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