Study of intestinal malabsorption diseases as cause of monosymptomatic short stature

Oliveira, MC; Fj, Reis; Aj, Chagas; G, Brasileiro Filho; Bahia, Mirleide Chaar; Ld, Silva; Fj, Penna

doi:10.2223/jped.435

Cited by 2 publications

(10 citation statements)

References 15 publications

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“…Our literature search retrieved 1162 article titles, of which 71 were found eligible for full‐text review and eligibility assessment. The eligibility criteria were fulfilled by 17 studies, and they were finally included in the systematic review and meta‐analysis 27–43 . The reasons for excluding the remaining studies are summarized in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…Studies with unclear methodology, such as lack of adequate description of screening methods, 45–48 inclusion of patients having failure to thrive and not short stature, 49 and studies where diagnosis of CeD was not definitive, 50 were excluded. Studies utilizing only IgA AGA for serology testing were excluded from analysis for seroprevalence of CeD 27,30,37 . As these studies used parallel testing strategy and all the included patients were biopsied, they were included for the analysis of biopsy‐proven CeD.…”

Section: Resultsmentioning

confidence: 99%

“…All‐cause short stature was evaluated in six studies comprising 1582 patients, 28,33,36,39,40,43 while the remaining 11 studies included 2177 patients with idiopathic short stature 27,29–32,35,37,38,41,42,51 . In six studies evaluating idiopathic short stature, the respective investigators had biopsied all the screened patients 27,29,30,32,34,37 ; in the remaining 11 studies, patients underwent duodenal biopsies sequentially once they were found to be seropositive for CeD 28,31,33,35,36,38–43 . IgA AGA were used by three studies, 27,30,37 and the rest of the studies used anti‐tTG‐ab 28,29,33,34,40,41 or anti‐EMA 32,35,38,42 .…”

Section: Resultsmentioning

confidence: 99%

“…The eligibility criteria were fulfilled by 17 studies, and they were finally included in the systematic review and meta-analysis. [27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43] The reasons for excluding the remaining studies are summarized in Figure 1. In case of multiple publications by the same group of authors involving the same group of patients, 28,44 the paper with better quality and with detailed reporting of methods and results was included in the final analysis.…”

Section: Resultsmentioning

confidence: 99%

“…Studies utilizing only IgA AGA for serology testing were excluded from analysis for seroprevalence of CeD. 27,30,37 As these studies used parallel testing strategy and all the included patients were biopsied, they were included for the analysis of biopsy-proven CeD.…”

Section: Resultsmentioning

confidence: 99%

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Prevalence of celiac disease in patients with short stature: A systematic review and meta‐analysis

Singh

Farooqui

et al. 2020

J of Gastro and Hepatol

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Background and AimShort stature is a common extraintestinal manifestation of celiac disease (CeD). We conducted a systematic review and meta‐analysis to assess the global prevalence of CeD in patients presenting with short stature.MethodsWe searched Medline and EMBASE databases for the keywords “celiac disease, coeliac disease, anti‐gliadin, tissue transglutaminase antibody, anti‐endomysial antibody, short stature and growth retardation.” All the studies published from January 1991 to May 2020 were included. Patients without any prior evaluation for short stature were classified as all‐cause short stature, while prior evaluated patients, where no cause was found for short stature, were classified as idiopathic short stature. The diagnosis of CeD was based on the European Society for Paediatric Gastroenterology, Hepatology and Nutrition guidelines. A random‐effects model was used to pool the data.ResultsSeventeen studies screening 3759 patients (1582 with all‐cause short stature and 2177 with idiopathic short stature) were included. The pooled seroprevalence of CeD based on positive anti‐tissue transglutaminase antibody and anti‐endomysial antibody was 11.2% (95% CI 4.0–21.2%; I2 = 86%) and 9.7% (95% CI 2.7–20.2%; I2 = 95%) for all‐cause and idiopathic short stature, respectively. Similarly, pooled prevalence of biopsy‐confirmed CeD was 7.4% (95% CI 4.7–10.6%; I2 = 76%) and 11.6% (95% CI 4.1–22.2%; I2 = 97%), for all‐cause and idiopathic short stature, respectively. There was an overall severe risk of selection bias and significant heterogeneity in the pooled results.ConclusionsApproximately one in 14 patients with all‐cause short stature and one in nine patients with idiopathic short stature had biopsy‐confirmed CeD. Therefore, evaluation for CeD may be prudent in all patients with short stature.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Prevalence of celiac disease in patients with short stature: A systematic review and meta‐analysis

Singh

Farooqui

et al. 2020

J of Gastro and Hepatol

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Determining IgA and IgG Antigliadin, IgA Antitransglutaminase, and Antiendomysial Antibodies in Monkey Esophagus and in Umbilical Cord for Diagnosis of Celiac Disease in Developing Countries

Bahia

Penna²,

Sampaio³

et al. 2007

J. pediatr. gastroenterol. nutr.

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TgA has been recommended for screening patients with celiac disease. Considering the similar sensitivity and specificity of IgA-AGA and TgA and their correlations in the multivariate analysis, both are applicable for this purpose. However, because TgA tests are highly costly and celiac disease is associated with IgA deficiency, the determination of IgA-AGA and IgG-AGA, followed by AEA-CO, is suitable for screening in developing countries, provided a cutoff point for these examinations is established. The results of antiendomysial antibodies in umbilical cord overlapped those in monkey esophagus. Therefore, umbilical cord should be used as a substrate instead of specimens from endangered species.

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Study of intestinal malabsorption diseases as cause of monosymptomatic short stature

Cited by 2 publications

References 15 publications

Prevalence of celiac disease in patients with short stature: A systematic review and meta‐analysis

Prevalence of celiac disease in patients with short stature: A systematic review and meta‐analysis

Determining IgA and IgG Antigliadin, IgA Antitransglutaminase, and Antiendomysial Antibodies in Monkey Esophagus and in Umbilical Cord for Diagnosis of Celiac Disease in Developing Countries

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