Study of insomnia and associated factors in traumatic brain injury

Jain, Akhilesh; Mittal, Radhey Shyam; Sharma, Anil; Sharma, Anand; Gupta, I. D.

doi:10.1016/j.ajp.2013.12.017

Cited by 26 publications

(32 citation statements)

References 29 publications

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“…Insufficient pain management is a primary contributor to increased insomnia in patients with mild TBI (Lavigne et al, 2015). Mild TBI is also often repetitive, which increases the likelihood for insomnia (Jain et al, 2014). In a survey of 452 individuals with TBI, 50.2% reported insomnia symptoms and 29.4% fulfilled the DSM-IV diagnostic criteria for an insomnia syndrome (Ouellet et al, 2006).…”

Section: Sleep and Tbimentioning

confidence: 99%

Sleep disruption and the sequelae associated with traumatic brain injury

Lucke‐Wold

Smith

Nguyen

et al. 2015

Neuroscience & Biobehavioral Reviews

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Sleep disruption, which includes a loss of sleep as well as poor quality fragmented sleep, frequently follows traumatic brain injury (TBI) impacting a large number of patients each year in the United States. Fragmented and/or disrupted sleep can worsen neuropsychiatric, behavioral, and physical symptoms of TBI. Additionally, sleep disruption impairs recovery and can lead to cognitive decline. The most common sleep disruption following TBI is insomnia, which is difficulty staying asleep. The consequences of disrupted sleep following injury range from deranged metabolomics and blood brain barrier compromise to altered neuroplasticity and degeneration. There are several theories for why sleep is necessary (e.g., glymphatic clearance and metabolic regulation) and these may help explain how sleep disruption contributes to degeneration within the brain. Experimental data indicate disrupted sleep allows hyperphosphorylated tau and amyloid β plaques to accumulate. As sleep disruption may act as a cellular stressor, target areas warranting further scientific investigation include the increase in endoplasmic reticulum and oxidative stress following acute periods of sleep deprivation. Potential treatment options for restoring the normal sleep cycle include melatonin derivatives and cognitive behavioral therapy.

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Section: Sleep and Tbimentioning

confidence: 99%

Sleep disruption and the sequelae associated with traumatic brain injury

Lucke‐Wold

Smith

Nguyen

et al. 2015

Neuroscience & Biobehavioral Reviews

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“…The Insomnia Severity Index (ISI; Bastien, Vallières, & Morin, 2001) is one of the most frequently used measures to assess the severity of and distress associated with insomnia symptoms in both general and clinical populations as well as in both civilian and military populations (Bryan, 2013; Jain, Mittal, Sharma, Sharma, & Gupta, 2014; Mollayeva et al, 2016; Spira, Lathan, Bleiberg, & Tsao, 2014; Sullivan, Berndt, Edmed, Smith, & Allan, 2016). Given the recognized importance of insomnia in TBI, the instrument has been increasingly used to study insomnia in Veterans who have sustained a TBI (Bryan, 2013; Spira et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Psychometric Characteristics of the Insomnia Severity Index in Veterans With History of Traumatic Brain Injury

Kaufmann

Orff

Moore

et al. 2017

Behavioral Sleep Medicine

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Objective/Background The Insomnia Severity Index (ISI) is a widely used self-report measure of insomnia symptoms, however to date this measure has not been validated or well-characterized in Veterans who have experienced traumatic brain injury (TBI). This study assessed the psychometric properties and convergent, divergent, construct, and discriminate validity of the ISI in Veterans with a history of TBI. Participants Eighty-three Veterans with history of TBI seen in the VA San Diego Healthcare System as part of a research protocol. Methods Measures included the ISI, Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale, Neurobehavioral Symptom Inventory, Beck Depression Inventory-II, Beck Anxiety Inventory, and PTSD Checklist–Military Version. Results The ISI demonstrated moderate to strong/excellent convergent and divergent validity. A principal component analysis indicated a single construct with excellent internal consistency (Chronbach’s alpha=0.92). In exploratory analyses, the ISI discriminated well between those with (73%) and without (27%) sleep disturbance based on the PSQI. Conclusions Results from this study indicate good validity of the ISI in assessing insomnia in Veterans with history of TBI and suggest a cut-off score not dissimilar from non-TBI populations. Findings from this study can help inform clinical applicability of the ISI, as well as future studies of insomnia in TBI.

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“…Some studies suggest that insomnia may contribute to depression and poor quality of life (6). Also, studies show that insomnia is common among other patient populations after injury (e.g., traumatic brain injury)(7), and there is some evidence that these patients can benefit from adapted versions of standard treatment of insomnia(8). …”

Section: Overview Of Sleep Disturbances In Individuals With Spinal Comentioning

confidence: 99%

Sleep-Disordered Breathing and Spinal Cord Injury: Challenges and Opportunities

Sankari

Martin

Badr

2017

Curr Sleep Medicine Rep

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Purpose of review This paper focuses on the sleep disorders in patients with spinal cord injury (SCI/D), particularly mechanism of sleep disordered breathing (SDB) and challenges in diagnosis and management. Based on a review of recent literatures and studies the paper summarizes some main challenges with respect to management of SDB in patients with SCI; and what are the responsible mechanisms of disease? What are the barriers in diagnosing and treating SDB using standard treatment such as positive airway pressure (CPAP)?. Recent findings Previous studies have shown that most SCI/D patients have SDB with heterogeneity in prevalence mainly related to using different definition or methods of diagnosing SDB, while recent studies using new definition of SDB based on recommended criteria from the American Academy of Sleep Medicine (AASM) and also include the data on effect of SCI/D level on prevalence and describe different type of SDB. Furthermore, recent data describes simplified method of diagnosing SDB by using a combination of home sleep apnea testing and transcutaneous CO2 monitoring. Finally, emerging data has been pointing at strong relationship between SDB and cardiovascular disease including nocturnal hypertension in patients with SCI/D. Summary The findings indicate that early testing for SDB and associated cardiovascular disease in patients with SCI is recommended and could be beneficial in reduced the high morbidity and mortality in this group of patients with disability. In addition, studies on treatment of other sleep disorders in SCI/D are not available to inform clinical decision making. Understanding the pathophysiology of sleep disorders in SCI/D is critical for the development of new effective therapies. This review provides evidence for best practices; highlights new discoveries for the diagnosis and management of sleep disorders in SCI/D, and discuss challenges and future directions.

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Study of insomnia and associated factors in traumatic brain injury

Cited by 26 publications

References 29 publications

Sleep disruption and the sequelae associated with traumatic brain injury

Sleep disruption and the sequelae associated with traumatic brain injury

Psychometric Characteristics of the Insomnia Severity Index in Veterans With History of Traumatic Brain Injury

Sleep-Disordered Breathing and Spinal Cord Injury: Challenges and Opportunities

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