Study of Infertile Couples Attending a Teaching Hospital in Eastern Nepal

Subedi, Sandip; Lamichhane, Sabina; Chhetry, Manisha

doi:10.31729/jnma.2833

Cited by 12 publications

(17 citation statements)

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“…3 We found the mean age at which couples seek treatment is 27.25 ± DOI: 10.3126/jpn.v10i2.27267 4.12 years, similar to reports from other researchers. 4,10 This mean age is also near to the documented global mean age of childbearing since 1970. 3 In the age below 20 years and above 45 years, fewer couples are seeking a child.…”

Section: Discussionmentioning

confidence: 64%

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Serum anti-thyroid peroxidase antibody in infertile Nepalese women: a hospital-based study

et al. 2020

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Background: Infertility is a critical component of reproductive health that can precipitate agony for a couple. Antibodies against thyroid peroxidase can lead to not only autoimmune thyroiditis which is highly prevalent in women, but may also represent a generalized autoimmune milieu in our body that can be associated with infertility. This study aims to assess anti-thyroid peroxidase antibodies in female patients with infertility. Materials and Methods: This is a cross-sectional study carried out in the Department of Biochemistry, Tribhuvan University Teaching Hospital over three months (November 2018 to January 2019). All women undergoing work up at the infertility clinic with reported normal thyroid function and otherwise normal levels of reproductive hormones were recruited for this study. Anti-thyroid peroxidase levels were estimated in their serum samples by enzyme-linked immunosorbent assay. Results: Of the eighty-seven females that were selected for the study, 54 were infertile females, 16 were pregnant women in their first trimester and 17 were non-pregnant females in their reproductive age. Four positive cases of anti-thyroid peroxidase were detected among infertile females (7.4% within the group), 2 amid non-pregnant females (11.76% within-group) while no positive cases were detected within the pregnant group. However, the occurrence was not statistically significant (p=0.4). The pregnant group showed higher mean anti-thyroid peroxidase levels compared to both infertile and non-pregnant females though statistical significance could not be established (p=0.066). Conclusions: Functional autoimmune antibodies, like anti-thyroid peroxidase levels, do not have a significant primary association with infertility.

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Section: Discussionmentioning

confidence: 64%

“…The incidence of primary infertility cases was 1.7%. 4 Over the last decade, thyroid screening has been a routine procedure in all pregnant and infertile females. Among thyroid disorders and autoimmune diseases, thyroid autoimmunity is the most prevalent autoimmune condition affecting up to 5-20% of women in the reproductive life phase.…”

Section: Introductionmentioning

confidence: 99%

Serum anti-thyroid peroxidase antibody in infertile Nepalese women: a hospital-based study

et al. 2020

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“…Infertility affects approximately 15% of reproductive-aged couples with recent prevalence between 9 and 18% of the general population ( Pundir and ELToukhy, 2010 , Aghajanova et al, 2017 ). It is classified into primary, in which the couples have never conceived at any stage, or secondary when previous pregnancy, although not necessarily a live birth, has occurred ( Subedi et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of hysterosalpingographic findings among patients presenting with infertility

Toufig

Benameur

Twfieg

et al. 2020

Saudi Journal of Biological Sciences

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Background Infertility is a global health issue and hysterosalpingography (HSG) is a valuable radiological tool in infertility workup and remains a main modality for investigating female infertility. However, the HSG findings of infertility are not the same worldwide. This study aimed at evaluating the incidence of HSG findings in patients investigated for primary and secondary infertility, correlating these findings with their clinical data that reflect the infertility causes and comparing the findings with previous international studies. Methods A prospective descriptive study of 75 female patients referred, as cases of infertility, for HSG examination in Elrebat Hospital and Khartoum Advanced Diagnostic Center. HSG was performed in the first half of the cycle. The procedure and its complications, were explained to the patients and informed consents were obtained. Patients with active pelvic infection and active uterine or vaginal bleeding were excluded from the study. Using aseptic technique and with proper patient’s positioning, iodinated contrast was introduced into the cervix under fluoroscopic monitoring, to demonstrate the uterine cavity, fallopian tubes and free spillage into the peritoneal cavity. Personal data, clinical data and HSG findings were analyzed using SPSS version 23. Results The commonest age group seen was 26–36 years. Close incidences of primary and secondary infertility were detected. 52.7% had abnormal findings in HSG. Tubal pathology (42.7%) being the most common abnormality, followed by uterine and combined abnormalities. There was strong association between past medical history suggesting pelvic inflammatory disease (PID) or past history suggesting tubal blockage secondary to abdominopelvic surgery and tubal abnormalities. Conclusion HSG examinations revealed that the most common abnormality was tubal blockage possibly complicating PID and abdominopelvic surgeries. This reflects the HSG diagnostic and therapeutic role in the assessment of female infertility and the further needs for more preventive measures targeting the reduction of tubal pathologies in developing countries.

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“…1,3 The estimated incidence of infertility among South Asian countries were 05% in Pakistan, 04% in Bangladesh and 06% in Nepal. 4,5 Infertility is labeled as a global health issue by World Health Organization which does not receive adequate attention which it deserves. 3 Infertility is defined as failure to conceive and have a child after having regular sexual intercourse for more than one year and in the absence of any contraceptive measures.…”

Section: Introductionmentioning

confidence: 99%

“…2,10 This is because children are believed to play an important and active role in the care of their elderly family members as well as to continue their lineage. 2,5,11 This study is conducted to find the prevalence and etiology of female infertility as well as to study the associated biochemical abnormalities in infertile patients.…”

Section: Introductionmentioning

confidence: 99%

Female Infertility

Tayyab

Yasmin

Anjum

2018

TPMJ

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Objectives: To find the prevalence and etiology of female infertility as well asto study the associated biochemical abnormalities. Place and Duration of Study: Departmentof Gynecology, Frontier Medical & Dental College, Abbottabad, from July 2016 to June 2017.Study Design: Case-control study. Materials & Methods: All married patients between theages of 18-35 years were included in the study. Sixty patients who met eligibility criteria wereincluded in one group while sixty normal healthy individuals were included in the second groupas controls. Detailed history was taken focusing specifically on age and duration of marriage,menstrual and sexual history and drug history especially use of contraceptives. A thoroughclinical examination was performed by an experienced clinician and body mass index wascalculated. Laboratory investigations included complete blood examination, hormonal assays,ultrasonography in female patients and semen analysis in male partners. Tubal patency wasassessed by hysterosalpingography and laparoscopy was performed, if required. Results: Themean age of infertile patients was 27.4±4.9 years and mean duration of their marriage was6.6±2.9 years. Majority of patients in our study belonged to lower socio-economic status inboth groups. About 50% belonged to lower and 16.67% to poor socio-economic group amonginfertile subjects while 60% belonged to lower and 10% to poor socio-economic group amongcontrols. The chief presenting complaint was oligomenorrhea followed by galactorrhea anddyspareunia. The chiefunderlying condition was luteal phase deficiency, 60%, followed byhyperprolactinemia, 16.66%, and polycystic ovarian disease, 10%, fibroid uterus, 6.7%, andendometriosis, 6.7%. The serum estradiol levels were 114.6±48.7pg/ml and 233.2±70.8 pg/ml in follicular and luteal phase among infertile couples. Similarly, serum progesterone, serumprolactin, serum FSH and LH levels were 3.6±4.2 ng/ml, 18.1±12 ng/ml, 6.7±2.7 mIU/ml, and7±6.6 mIU/ml among infertile patients respectively. Serum estradiol and prolactin levels weresignificantly higher among infertile patients. Conclusion: Infertility is not a very uncommoncondition in our country. It is the need of time to increase awareness and educate massesabout infertility as well as establish infertility clinics for early detection and treatment of infertilecouples. Large scale multi-centric studies should also be conducted to accurately estimate theprevalence and etiology of infertility in our region.

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Study of Infertile Couples Attending a Teaching Hospital in Eastern Nepal

Cited by 12 publications

References 5 publications

Serum anti-thyroid peroxidase antibody in infertile Nepalese women: a hospital-based study

Serum anti-thyroid peroxidase antibody in infertile Nepalese women: a hospital-based study

Evaluation of hysterosalpingographic findings among patients presenting with infertility

Female Infertility

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