Study of Hybrid Modification with Humic Acids of Environmentally Safe Biodegradable Hydrogel Films Based on Hydroxypropyl Methylcellulose

Abstract

The possibility of increasing the complexity of the operational properties of environmentally safe biodegradable polymer hydrogel materials based on hydroxypropyl methylcellulose due to modification by humic acids from lignite is considered. As a result of this research, environmentally safe hybrid hydrogel films with antibacterial properties were received. In the framework of physicochemical studies, it was determined by IR spectroscopy that hydroxypropyl methylcellulose modified with humic acids hybridmaterials are received by the mechanism of matrix synthesis, which is accompanied by hydroxypropyl methylcellulose crosslinking through multipoint interaction with the carboxyl group of humic acids. Regularities in terms of changes in water absorption, gelation time, and mold emergence time regarding the environmentally safe biodegradable polymer hydrogel materials based on hydroxypropyl methylcellulose depending on the humic acid content were revealed. It was established that the optimal humic acid content in environmentally safe biodegradable hydrogel films with bactericidal properties based on hydroxypropyl methylcellulose is 15% by mass. It was also established that the hybrid modification of hydroxypropyl methylcellulose with humic acids allows them to preserve their biodegradation properties while giving them antibacterial properties. The environmentally safe biodegradable hydrogel films with bactericidal properties based on hydroxypropyl methylcellulose and humic acids are superior in their operational characteristics to known similar biodegradable hydrogel films based on natural biopolymers.

Waste to Wealth Approach: Improved Antimicrobial Properties in Bioactive Hydrogels through Humic Substance–Gelatin Chemical Conjugation

“…The obtained results showed that the antimicrobial performance improves by increasing the HS amount within the hybrid gels. In addition, gels treated with EDC exhibit a higher inhibition diameter and lower MIC values compared to those of the corresponding physical gels, suggesting that the hybrid modification with HS using EDC chemistry allows for the reduction in their water absorption and gives them better antibacterial properties . Indeed, the higher antimicrobial capacity of humic gels was related to the chemical cross-linking between gelatin and HS.…”

“…In addition, gels treated with EDC exhibit a higher inhibition diameter 74 and lower MIC values compared to those of the corresponding physical gels, suggesting that the hybrid modification with HS using EDC chemistry allows for the reduction in their water absorption and gives them better antibacterial properties. 83 Indeed, the higher antimicrobial capacity of humic gels was related to the chemical cross-linking between gelatin and HS. Notably, larger water uptake determined by HS cross-linking at large HS content might enable better exposure of active moieties and determine a more effective biocide action.…”

Modeling of Smart Bio-Medical Active Polymeric Hydrogel Transdermal Materials

“…The swelling degree of smart biologically active polymeric transdermal hydrogel was calculated according to the following formula [10]:…”

“…Additionally, nanocellulose promoted bioadhesion and cell growth in the smart hydrogel medium. In addition, in our previous work, it was proved that humic substances, due to their ability to cross-link some polysaccharides and proteins, are materials that improve not only the mechanical properties of polymer hydrogels but also directly affect such hydrogel properties as transdermal ability [9,10].…”

“…Our previous works proved that humic substances are one of the materials that improve the mechanical properties of polymer hydrogels [10] and directly affect their transdermal properties [10].…”