Study of hybrid alginate/gelatin hydrogel-incorporated niosomal Aloe vera capable of sustained release of Aloe vera as potential skin wound dressing

Dadashzadeh, Arezoo; Imani, Rana; Moghassemi, Saeid; Omidfar, Kobra; Abolfathi, Nabiollah

doi:10.1007/s00289-019-02753-8

Cited by 39 publications

(16 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6 A substantial number of research papers have been published about the use of Aloe vera and Acalypha indica, along with their applications in both synthetic and natural materials for wound healing, drug delivery systems, super-oleophobic and hydrophobic thin films and tissue engineering. [12][13][14][15][16][17][18] Researchers have observed that the addition of natural plant has extensively improved the overall efficacy of the resultant product.…”

Section: Introductionmentioning

confidence: 99%

Non-wettable antibacterial thin film: PS/Aloe vera and PS/Acalypha indica

Seifunnisha

Swathi

Shanthi

2021

Polymers and Polymer Composites

View full text Add to dashboard Cite

The water and liquid repelling materials due to their low surface energy and specific nanometer and micrometer scale roughness have particular interest due to the great variety of potential applications ranging from self-cleaning surfaces to microfluidic devices. Natural plant-based polymer hydrophobic coatings have several engineering and biomedical applications. In this study, natural plants such as Aloe vera and Acalypha indica were used for preparation of polystyrene hydrophobic film by the dip-coating method. The effects of Aloe vera and Acalypha indica extract on the morphological, structural, optical and antibacterial properties of as-prepared polystyrene thin films were studied. FTIR spectra were carried out to ascertain the presence of functional groups in the prepared polymeric film. Contact angle measurement showed that the PS/ Aloe vera has higher anti-wetting property (CA = 112°) compared to PS/ Acalypha indica (CA = 104°), which could be confirmed by the surface morphology analysis. Furthermore, the effective antibacterial activity against Klebsiella pneumoniae and Staphylococcus aureus was compared by agar-well diffusion method. The observed result reports, PS with Aloe vera film exhibit higher hydrophobic with antibacterial activity compared to PS with Acalypha indica film. In addition, the PS/ Aloe vera coated cotton maintained their repellent properties against various liquids for 10 h, while PS/ Acalypha indica coated cotton exhibit anti-wetting property for 4 h. These findings open up new avenues for the preparation of hydrophobic film for various biomedical applications.

show abstract

Section: Introductionmentioning

confidence: 99%

Non-wettable antibacterial thin film: PS/Aloe vera and PS/Acalypha indica

Seifunnisha

Swathi

Shanthi

2021

Polymers and Polymer Composites

View full text Add to dashboard Cite

show abstract

“…LONs were prepared by a reverse-phase evaporation method (REV), one of the most common methods for preparing nanovesicular systems used for the loading of various kinds of agents, including lipids, hormones, and proteins [14,29,30]. Briefly, Span60 (S7010; Sigma, Bornem, Belgium) and cholesterol (C8667; Sigma) in a 1:1 molar ratio (50.32 mg and 48.39 mg, respectively) were mixed into 5 mL of chloroform and methanol in a 9:1 volume ratio.…”

Section: Niosomal Lavender Oil Preparation Methodsmentioning

confidence: 99%

Safety of Lavender Oil-Loaded Niosomes for In Vitro Culture and Biomedical Applications

et al. 2022

Self Cite

View full text Add to dashboard Cite

(1) Background: Essential oils have long been used as therapeutic agents. Lavender (Lavandula angustifolia) oil (LO) is an antispasmodic, anticonvulsant, relaxant, painkilling, and antimicrobial essential oil investigated as a natural substance for biomedical therapies. Nanoparticles have shown significant promise in improving drug delivery and efficacy. Considering these benefits, the aim of this study was to evaluate the toxicity of LO and lavender oil niosomes (LONs) in stem cells and myofibroblast models cultured in vitro. (2) Methods: Adipose tissue-derived stem cells and myometrial cells were cultured with LO or LONs at different concentrations (0, 0.016%, 0.031%, and 0.063%) and toxicity was evaluated with PrestoBlue™ and live/dead assay using calcein and ethidium homodimer. (3) Results: Cell viability was similar to controls in all groups, except in 0.063% LO for myometrial cells, which showed lower viability than the control medium. (4) Conclusion: These results suggest that both LO and LONs are safe for cell culture and may be used for pharmaceutical and biomedical therapies in future applications in regenerative medicine.

show abstract

“…Results demonstrated that niosomes could efficiently encapsulate Aloe Vera extract, which is known for its stimulating effects in the proliferation of fibroblasts. The prepared hybrid system also sustains the therapeutic agent’s release [ 90 ]. Moxifloxacin has shown excellent potential against a wide range of bacteria which may help wound healing and makes it an option for treating wound infection.…”

Section: Mechanism Of Lipid-based Drug Delivery Systemsmentioning

confidence: 99%

Combinational System of Lipid-Based Nanocarriers and Biodegradable Polymers for Wound Healing: An Updated Review

Far

Naimi-Jamal

Sedaghat

et al. 2023

JFB

View full text Add to dashboard Cite

Skin wounds have imposed serious socioeconomic burdens on healthcare providers and patients. There are just more than 25,000 burn injury-related deaths reported each year. Conventional treatments do not often allow the re-establishment of the function of affected regions and structures, resulting in dehydration and wound infections. Many nanocarriers, such as lipid-based systems or biobased and biodegradable polymers and their associated platforms, are favorable in wound healing due to their ability to promote cell adhesion and migration, thus improving wound healing and reducing scarring. Hence, many researchers have focused on developing new wound dressings based on such compounds with desirable effects. However, when applied in wound healing, some problems occur, such as the high cost of public health, novel treatments emphasizing reduced healthcare costs, and increasing quality of treatment outcomes. The integrated hybrid systems of lipid-based nanocarriers (LNCs) and polymer-based systems can be promising as the solution for the above problems in the wound healing process. Furthermore, novel drug delivery systems showed more effective release of therapeutic agents, suitable mimicking of the physiological environment, and improvement in the function of the single system. This review highlights recent advances in lipid-based systems and the role of lipid-based carriers and biodegradable polymers in wound healing.

show abstract

Study of hybrid alginate/gelatin hydrogel-incorporated niosomal Aloe vera capable of sustained release of Aloe vera as potential skin wound dressing

Cited by 39 publications

References 43 publications

Non-wettable antibacterial thin film: PS/Aloe vera and PS/Acalypha indica

Non-wettable antibacterial thin film: PS/Aloe vera and PS/Acalypha indica

Safety of Lavender Oil-Loaded Niosomes for In Vitro Culture and Biomedical Applications

Combinational System of Lipid-Based Nanocarriers and Biodegradable Polymers for Wound Healing: An Updated Review

Contact Info

Product

Resources

About