Study of histomorphological variants of leiomyoma

Kakulapati, Bharani; Janaki, MG; Rani, R Swarupa; Hussain4, S Hasham; Sarvani, B Chakri

doi:10.26611/1051321

Cited by 3 publications

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“…Present study showed menorrhagia and abdominal pain were the predominant presenting chief complaints of the patients accounted 48.58 and 38.43%, respectively. This finding was consistent with the studies done by Geethamala et al 6 and Kakulapati et al 8 Most common location of leiomyoma was intramural (54.29%) followed by submucosal (10%). This observation was analogous to the study done by Geethamala et al 6 and Naz et al 9 In the present study, degenerative changes were observed in 48 cases of leiomyoma (68.57%).…”

Section: Discussionsupporting

confidence: 93%

“…Hyaline degeneration was the most common degenerative change accounting 79.17% cases. Similar findings were seen in the study by Geethamala et al, 6 Kakulapati et al 8 and Naz et al, 9 which showed that hyaline degeneration as commonest degenerative change in 59.48, 62.5, and 88.41% of cases, respectively. Calcification was the second most common degenerative change seen in 10.41% of cases which was similar finding observed by Kakulapati et al 8 in their study.…”

Section: Discussionsupporting

confidence: 89%

“…Similar findings were seen in the study by Geethamala et al, 6 Kakulapati et al 8 and Naz et al, 9 which showed that hyaline degeneration as commonest degenerative change in 59.48, 62.5, and 88.41% of cases, respectively. Calcification was the second most common degenerative change seen in 10.41% of cases which was similar finding observed by Kakulapati et al 8 in their study. The other degenerative changes observed in our study were one case (2.08%) each of cystic degeneration, red degeneration (apoplectic change) (Fig.…”

Section: Discussionsupporting

confidence: 89%

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Histomorphological Spectrum of Uterine Smooth Muscle Tumors

Bolde¹,

Chavhan²,

Rathod³

et al. 2022

Journal of South Asian Federation of Obstetrics and Gynaecology

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Introduction: Uterine smooth muscle tumors are the most common tumors of female genital tract and among these leiomyomas predominate. Leiomyomas most commonly occur during the reproductive years in women with manifestation of abnormal uterine bleeding and abdominal pain. These exhibit wide range of morphological variants and secondary changes. Here, we present a study of 70 cases, which includes rare variants and degenerative changes in leiomyomas. Materials and methods:A retrospective study conducted in a department of pathology for a period of 1 year from January 2019 to December 2019 at a tertiary care hospital. Seventy patients were diagnosed as leiomyoma on histopathological examination of 124 hysterectomy specimens and one myomectomy specimen and included in the study. Detailed microanatomic features were studied and recorded. Result: Uterine leiomyoma was most common among the age-group of 41-50 years of age (64.21%). Most common location was intramural (54.29%). Secondary changes were observed in 48 cases (68.57%). Most common secondary change was hyaline degeneration noted in 38 cases (79.17%). Classical variant of leiomyoma was seen in 66 cases (94.28%) followed by one case (1.43%) each of symplastic, neurilemmoma-like, lymphocyte-rich, and cellular leiomyoma and leiomyomas with rare secondary changes like osseous and chondroid metaplasia. Conclusion: Uterine smooth muscle tumors are commonly seen in perimenopausal females. Leiomyoma is associated with various pathologies comprising of degenerative changes and rare variants which sometimes can be misdiagnosed as malignancy. Hence, a vigilant histopathological examination is necessary to identify the various spectrum of uterine leiomyomas and associated pathologies.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 89%

See 1 more Smart Citation

Histomorphological Spectrum of Uterine Smooth Muscle Tumors

Bolde¹,

Chavhan²,

Rathod³

et al. 2022

Journal of South Asian Federation of Obstetrics and Gynaecology

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A Clinicopathological Study of Uterine Leiomyoma in Women Above 30 Years in a Tertiary Care Hospital of Assam

Ahmed¹,

Dowerah²,

Das³

2022

IJAR

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Background: Leiomyoma of uterus is the most common benign neoplasm in women. The clinical presentation differs from patients to patients. Due to the complex interactions between steroid hormones, growth hormones and mutations in the myometrium, leiomyoma undergoes degenerative changes and coexists with varied benign and malignant lesions of the endomyometrium and cervix. Aims And Objectives: a) To study the incidence of leiomyoma in hysterectomy specimens. b) To study the histopathological variants and secondary changes in leiomyoma. c) To study the associated histopathological changes in the endomyometrium and cervix. Material And Methods: The present study is conducted in the Department of Pathology, Fakhruddin Ali Ahmed Medical College, Barpeta from July, 2019 to December, 2020. A total of 140 hysterectomy specimens with or without salpingo-oophorectomy of women above 30 years were received. 77 cases diagnosed as leiomyoma on histopathological examination were included in the study and relevant clinical data were analyzed. Result: Uterine leiomyomas occurred mostly in women aged 31-40 years (50.65%). Menorrhagia (58.44%) and dysmenorrhea (32.47%) were the chief clinical manifestations. Most common location was intramural (68.83%). Secondary changes were observed in 20.78% cases of uterine leiomyoma with hyalinization as commonest histopathological nding. Leiomyoma variants was seen in 3.90 % and all of them were cellular leiomyoma. Associated endometrial hyperplasia without atypia (67.53%) and chronic cervicitis (71.42%) was the dominating endometrial and cervical pathology respectively. 33.77% cases had dual pathology of leiomyoma and adenomyosis. Conclusion: A detail and meticulous analysis of the indications for hysterectomy alongwith histopathological ndings play a signicant role in patient management and surveillance.

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Histomorphological Variants and Secondary Changes in Uterine Leiomyoma

Boopathy

Prakasam

Vincy

et al. 2021

ijsr

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BACKGROUND: Leiomyoma is one of the most common causes of Abnormal Uterine Bleeding. It occurs chiey in women during active reproductive years. It has a lot of morphological variants and secondary changes which may mimic malignancy clinically, radiologically and histologically. A few degenerative changes and variants like Atypical and Mitotically active Leiomyoma may be misdiagnosed as malignancy. It is imperative to have a good knowledge of Leiomyosarcoma as the treatment protocol varies. AIMS AND OBJECTIVES: To analyse the morphological variants and secondary changes in Leiomyoma and to study the associated changes in the endometrium. MATERIALS AND METHODS: 420 Hysterectomy specimens with Fibroid received at Govt. Kilpauk medical College, Chennai were studied from January 2018 to January 2020. RESULTS: Leiomyoma was seen in the reproductive age group and menorrhagia was the most common clinical presentation. Hyalinisation was the most common secondary change seen in Leiomyoma and cellular leiomyoma was the most common morphological variant. CONCLUSION:A good comprehensive and accurate knowledge of the morphological variants and secondary changes in Leiomyoma mandatory to avoid misdiagnosis and ensuring optimal patient management.

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Study of histomorphological variants of leiomyoma

Cited by 3 publications

References 0 publications

Histomorphological Spectrum of Uterine Smooth Muscle Tumors

Histomorphological Spectrum of Uterine Smooth Muscle Tumors

A Clinicopathological Study of Uterine Leiomyoma in Women Above 30 Years in a Tertiary Care Hospital of Assam

Histomorphological Variants and Secondary Changes in Uterine Leiomyoma

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