Study of hematological and biochemical changes in dengue fever at tertiary care hospital at Ahmedabad

Patel, Priyanka; Patel, Shilpa; Sabalpara, Monica Arvindbhai; Shah, Cherry K; Shah, Nailesh R

doi:10.5455/ijmsph.2016.07012016381

Cited by 12 publications

(14 citation statements)

References 7 publications

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“…3,19 In the present study, most were between 12-25 years, the average age was 32 years, with a slight male preponderance similar to others probably due to occupational exposure and increased recreational activity in men. 1,10,11 An analysis of hematology tests showed leucopenia in 36% of cases in the present study in concordance with others. 5,9 Few studies showed higher proportion and lower proportion of cases with leucopenia.…”

Section: Discussionsupporting

confidence: 92%

Correlation of thrombocytopenia with degree of atypical lymphocytosis as a prognostic indicator in dengue

2017

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Background: Dengue viral infections may occur as epidemics and are of public health concern in India especially due to high mortality in advanced stages. Early diagnosis and treatment reduces the mortality significantly. To assess the utility of atypical lymphocyte counts with relation to platelet counts as a marker for severe dengue.Methods: A total of 132 serologically proven (by rapid card method) cases of dengue with atypical lymphocytosis (≥10%) and thrombocytopenia (<150×109/l) were analyzed during November 2016. The complete blood counts (obtained from automated hematology analyzer and Leishman stained peripheral smears) were analyzed.Results: Dengue infections were mostly seen in younger age (12-25 years) with slight male predominance. The relevant haematology findings noted were leukopenia in 36% and severe thrombocytopenia (<50×109/l) in 57% of cases. The differential count showed lymphocytosis in 64% with significant (≥20%) atypical lymphocytes in 52% which inversely correlated with platelet counts. Atypical lymphocytosis (≥20%) was noted in 9% of cases with mild as against 32% of severe thrombocytopenia.Conclusions: Atypical lymphocyte count can be used as predictor of severe thrombocytopenia and severe dengue. This helps in early diagnosis and proper management and drastic reduction in mortality.

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Section: Discussionsupporting

confidence: 92%

Correlation of thrombocytopenia with degree of atypical lymphocytosis as a prognostic indicator in dengue

2017

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“…23,24 A few studies had a lower and others, a higher proportion of cases with leucopenia. 1,2,4,15,16,18,25 A normal leucocyte count was observed in 55% of cases in our study in concordance with few studies but it was lower and higher in other studies. 2,4,15,18,21,24 Leucocytosis was noted in 9% of cases in our study in concordance with few studies.…”

Section: Discussionsupporting

confidence: 91%

“…1 The clinical manifestations include headache, fever, retro orbital pain, myalgia, body pain, rash.…”

Section: Introductionmentioning

confidence: 99%

The total leucocyte count: its utility in dengue

2017

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Background: Dengue infections are public health concerns in India, where they occur in epidemics and have a high mortality in the advanced stages. Clinical features are nonspecific, and diagnosis is supported by lab features. One of these lab tests include total leucocyte count-easily available, simple and cost effective which is useful in small rural set ups for early diagnosis and prognosis of dengue. The aim of this study is to analyse the total leucocyte count patterns in dengue and assess its utility as early marker of dengue and prognosticator of severe dengue.Methods: A total of 132 serologically proven cases of dengue with total white cell counts (blood counts obtained by Automated hematology analyser) during November 2016 were analysed.Results: In our study, most cases were noted in the younger age group with a male predominance. The range of total leucocyte count was 1.1x109 /l to 14.3x109/l. Most (55%) had normal counts, leucopenia was noted in 36%, had an equal distribution in all ages and both sexes. 82% had mild leucopenia,52% of leucopenia cases were associated with severe thrombocytopenia. Almost half (47%) of leucopenia cases were NS1 positive while only 15% were antibody positive.59% of NS1 positive had leucopenia in contrast to 13% of antibody positive cases. While leucopenia was mostly (55%) associated with neutrophilia, lymphocytosis was seen in 74% of cases with a normal leucocyte count.Conclusions: Total leucocyte count is one of the simple, easily available, cost effective tests useful in small rural set ups for early diagnosis and prognosis in dengue and helps reduce the morbidity and mortality of dengue.

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“…The results of Singh R study [15] is similar to present study. The result of Patel PM study [14] and Singh R study [15] are similar to that of the present study.…”

Section: In Study Of Dengue Fever Male-to-female Ratio In Different Ssupporting

confidence: 90%

Dengue Fever- Its Clinical Profile, Radiological Findings, Haematological and Biochemical Parameters – Study From a Tertiary Care Hospital

Srinivas¹,

Rao²

2018

jemds

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BACKGROUND Dengue is a rapidly progressing self-limiting systemic viral infection transmitted between humans by mosquitoes. About two-fifth of world's population, mostly those in tropical and sub-tropical countries are at a risk of dengue infection. MATERIALS AND METHODSA hospital-based cross-sectional descriptive study was conducted in Rajiv Gandhi Institute of Medical Sciences, Ongole. A total of 233 patients who were clinically diagnosed cases of Dengue with subsequent confirmation by Dengue NS1 Ag/ Dengue IgM were selected in the study. Data was collected using a semi-structured questionnaire, either by direct interview with patients or patient's relatives and by clinical examination and from relevant investigations. RESULTSOut of the 233 study population, majority (44.6%, n= 104) belonged to 40 -59 years age group. Fever was the most common presenting symptom (99.6%) in the present study followed by myalgia in 60%, headache in 43.8%, joint pain in 35.6% and backache in 28.8%. Majority had low platelet count (68.2%). SGPT was altered in 65.2%, serum albumin in 33% and SGOT in 73.7% of the patients. 16.7% of patients had high random blood sugar level and 7.3% had high serum amylase levels. Dengue NS1 antigen was positive in 187 (80.3%) patients and 50 (21.5%) had dengue IgM positivity. The most common radiological finding in the present study was gall bladder wall oedema, which constituted 19.3% cases followed by ascites (9.4%), pleural effusion (9.5%), free fluid in Morrison pouch/ pelvis (2.6%) and pancreatitis (2.6%). CONCLUSIONUltrasonographic features like gall bladder wall oedema, pleural effusion and ascites should strongly favour diagnosis of dengue fever in a patient who presents with fever and thrombocytopenia, especially during an epidemic.

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Study of hematological and biochemical changes in dengue fever at tertiary care hospital at Ahmedabad

Cited by 12 publications

References 7 publications

Correlation of thrombocytopenia with degree of atypical lymphocytosis as a prognostic indicator in dengue

Correlation of thrombocytopenia with degree of atypical lymphocytosis as a prognostic indicator in dengue

The total leucocyte count: its utility in dengue

Dengue Fever- Its Clinical Profile, Radiological Findings, Haematological and Biochemical Parameters – Study From a Tertiary Care Hospital

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