Study of Hematocrit in Relation with Age and Gender Using Low Power Helium - Neon Laser Irradiation

Houssein, Hend A. A.; Jaafar, Mastura; Ali, Zalila; Timimi, Zahra Al; Mustafa, Fatin Hamimi

doi:10.1007/978-3-642-21729-6_117

Cited by 4 publications

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“…21 It should have a great absorption peak within 600nm-800nm because of the absorption of photons with wavelengths higher than 800nm does not produce enough energy to stimulate the oxygen to its singlet state so as the ability for creating a substantial yield of reactive oxygen species simultaneous irradiation. 15,16 Considering the penetration of light within the tissue increases with its wavelength, the agents with a strong absorbance in the intense red essentially like chlorins, bacteriochlorins, and phthalocyanines advance improvement in tumor control. It should have no obscure toxicity and approximately rapid clearance from the normal tissues, whereby minimizing phototoxic side impressions.…”

Section: Application Of Photosensitisers In Cancer Therapymentioning

confidence: 99%

“…14,15 CPDT can be used to treat some cancers or in precancerous conditions when the tumour, is on or near to the lining of internal organs like cancers that affect the oesophagus, head and neck, lung, mouth and skin (but not melanoma). 14,16 The biological damage happen as a result of the optical irritation of a photosensitizer in the existence of oxygen which is generally indicated to as "Photodynamic Action". 17 ROS have short halflife (< 1 picoseconds) which is responsible for localized nature of the effectiveness; and the unassuming energy need.…”

Section: Introductionmentioning

confidence: 99%

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Cancer Treatment Based on the Selective Accumulation of a Photosensitiser and Laser Light Irradiation: A Review

Timimi

2021

Bangladesh Med Res Counc Bull

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Background: Cancer Photodynamic Therapy (CPDT) is a promising future treatment quality based on the selective accumulation of a photosensitiser in the malignant tissues and the dependent irradiation with laser light. Objective: The aim of this work was to estimate an optimum effect involves the performance of a photosensitizing agent served by irradiation at a wavelength corresponding to an absorbance band of the sensitizer. In the appearance of oxygen, a series of effects lead to direct tumour cell death and damage to the microvasculature and initiation of a local inflammatory reaction. Methods: Photosensitiser is a material that sensitizes an organism, cell, or tissue to the light. It is a deeprooted part of CPDT, which absorbed by cancerous cells and exposed to laser light, gets activated, damaging and killing cancer cells. The direct targeting of laser source on hyper proliferative tissue and its preferential origin absorption at the targeted site gives rise CPDT double selectivity with least damage to adjacent normal tissues. Results: Photosensitiser absorbs the light and then produces an active form of oxygen, which destroys nearby cancer cells. The photosensitiser is able to spoil the blood vessels in the tumour, that way preventing cancer from receiving any necessary nutrients. The light which needed to activate most of the photosensitisers cannot pass through more than about one-third of an inch of tissue, because of that reason, the CPDT is usually used to treat cancer on or just under the skin or on the lining of internal organs. In addition, CPDT may activate the immune system to attack the tumour cells, directly killing cancer cells. Conclusion: This review focuses on the aspects of CPDT as an advanced and original site directed therapy for cancer treatment and the other non-oncogenic diseases. Minimal average of tissue toxicity controlled a long-term morbidity, deficiency of intrinsic or acquired resistance mechanisms. Bangladesh Med Res Counc Bull 2020; 46(3): 150-153

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Section: Application Of Photosensitisers In Cancer Therapymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cancer Treatment Based on the Selective Accumulation of a Photosensitiser and Laser Light Irradiation: A Review

Timimi

2021

Bangladesh Med Res Counc Bull

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“…Through this way, the blood while passing in the vein is exposed to laser beam. Various blood ingredients, including erythrocytes (red blood cells), platelets, neutrophils, eosinophils, and basophils; T cells and B cells, blood proteins such as serum albumin, globulins and so on, absorb laser beam [ 2 ]. It is acknowledged, that modification of these cells function following laser irradiation is ending with essential anti-infection immunity, enhanced the microcirculation, and additional benefits for body modifications.…”

Section: Introductionmentioning

confidence: 99%

Improvement of antibiotics absorption and regulation of tissue oxygenation through blood laser irradiation

Al-Timimi

2021

Heliyon

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A point of this work is to estimate the impact of laser blood irradiation controlled intravenously at the level of an antibiotic. Hundred and twenty grown-up female adult rabbits were utilized in this investigation. They were separated into two equivalent groups relying upon the method for managing of the antibiotic. First group injected with10 mg/kg b. w of Moxifloxacin antibiotic while second group was given the Moxifloxacin but in a type of a tablet, containing 10 mg/kg.b.w orally. Following, each group was partitioned into four equivalent subgroups; control and treated with laser therapy at different time. Gallium-Arsenide (GaAs) laser device, utilized for treatment, in wavelength 904 nm, power of 5mW, its include a connector by optical fiber with fine cannula fixed at its end. Rabbits of laser subgroup; were treated by presenting needle of cannula into ear-marginal vein for 10, 20 and 30min. Blood samples have been collected from both groups after 1, 2, 3, 4, 5 and 6 h intervals after treatment and had transmitted for analysis via a high-pressure liquid chromatography to determine level of Moxifloxacin in blood. The after-effects' revealed a regular increment in Moxifloxacin level (ng/ml) in two groups until 3 h followed with a rapid decline until the end of the experiment. Blood Irradiation through low-level laser enhances the concentration of Moxifloxacin in the serum whatsoever; was the rout of its performance, besides the irradiation help within quickened clearance of blood beginning the drug.

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“…Coagulation of Blood because of laser exposure arises due to the heating of components. It is a complex manner that embraces cell shape modification, cells membrane, denaturation of proteins & aggregation of components [3,4]. This therapy occurs at radiations intensities, which are so low that any biological effect, which occurs, is because of the radiation rather than the heating [5].…”

Section: Introductionmentioning

confidence: 99%

Impacts of laser energy doses in maintaining the shape and deformability of the red blood cell (morphological &physiological) in vitro

2020

Lett Appl NanoBioSci

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Lasers have been applied in various clinical procedures such as surgery and cardiology to clear occluded blood vessels. However, there subsists insight into the relevant parameters and their ability to develop a rheological property of blood. Two blood samples were used. Morphological changes that have been chosen to detect this effect on red cells were: echinocytes, dacrocytes, stomatocytes, keratocytes , schistocytes. Laser beams λ = 532nm , power 100 mw at different intervals (0, 1, 3, 6, and 10 seconds).Six slides prepared for each interval. Slides were irradiated and microscopic photographs were taken to observe changes in population of each poikilocytes were compared to non-irradiated control blood smears. The effects were listed in a table in the form of a scale. Various laser energy doses were able to reduce the population of some poikilocytes namely ( dacrocytes, stomatocytes) in a male and (echinocytes, dacrocytes, stomatocytes, keratocytes and schistocytes) in a female by one, two or three cells. A poikilocyte is a distorted red blood cell and bears different forms, for instance, created (echinocytes), teardrop (dacrocytes), bite cells (keratocytes) or even fragmented (schistocytes). Low-energy laser improves the monographic properties of red cells by enhancing ATPase activity, metabolic output, activity of antioxidant enzymes.

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Study of Hematocrit in Relation with Age and Gender Using Low Power Helium - Neon Laser Irradiation

Cited by 4 publications

References 0 publications

Cancer Treatment Based on the Selective Accumulation of a Photosensitiser and Laser Light Irradiation: A Review

Cancer Treatment Based on the Selective Accumulation of a Photosensitiser and Laser Light Irradiation: A Review

Improvement of antibiotics absorption and regulation of tissue oxygenation through blood laser irradiation

Impacts of laser energy doses in maintaining the shape and deformability of the red blood cell (morphological &physiological) in vitro

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