Study of Glycemic Control by Ketogenic Diet Supplemented with Different Oils in Type II Diabetic Rats

Abstract

In recent years, very low carbohydrate ketogenic diets (VLCKD) have been emphasized. While commonly debated and often opposed, these are clearly successful as a method for treating obesity, hyperlipidemia and diabetes at least in the short to medium term. Therefore, this research was conducted to investigate the impact of ketogenic diet (KD) supplemented with oil of either grape seed or fish and virgin olive on diabetic rats. Forty eight male albino rats weighing 200 to 210 g, were assigned into two main groups. The first group (n=8) was control negative group (-ve), the second main group (n=40) were intraperitoneally injected with a single dose of streptozotocin (STZ) [60 mg/kg b.w.] for induction of diabetes, then these rats were divided into five subgroups. Subgroup one was fed on the basal diet and served as a control positive group, while subgroup 2 was fed on KD only and subgroups from 3 to 5 were fed on KD supplemented with 4% oil of either grape seed or fish and virgin olive, respectively for 8 weeks. The results indicated that, STZ treated rats showed significant reduction (P≤0.05) in serum insulin concentration and increased glucose levels compared to normal rats. KD supplemented with oil of either grape seed or fish and virgin olive improved the biochemical changes due to diabetes. Furthermore, the intervention caused favorable changes in blood lipids and restored liver and kidney functions of the treated rats compared to the control positive group. In conclusion, the ketogenic diet and KD supplemented with oil of either grape seed or fish or virgin olive are potentially promising diets for diabetic patients.

التأثيرات المحتملة لزيت الزيتون والزعتر على الإجهاد التأکسدي ووظائف الکبد في الفئران المصابة بتليف الکبد

“…Meanwhile, triglycerides and cholesterol levels in the blood were much lower. Finally, H. Negm (53) found that using olive oil supplements improved liver and renal function. In the case of thyme, Shanon (39) found that adding a 10% aqueous extract of thyme to the drinking water of broiler chicken moms caused a decrease in liver enzymes.…”