Study of FTA-CFS test using monospecific anti-immunoglobulin conjugates IgG, IgM, and IgA

Leclerc, Guy J.; Giroux, Marie; Birry, A; Kasatiya, S. S.

doi:10.1136/sti.54.5.303

Cited by 3 publications

(3 citation statements)

References 13 publications

(15 reference statements)

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“…[9][10][11] We therefore obtained records on all patients with positive FTAabs results in the CSF from 1990 to 1999 at the Tygerberg Hospital, Cape Town, South Africa. These were extracted from a computerised hospital based data system, noting that the hospital has a geographically defined catchment area and provides both paediatric and psychiatric services.…”

Section: Methodsmentioning

confidence: 99%

Neurosyphilis in the modern era

Timmermans

Carr²

2004

Journal of Neurology, Neurosurgery & Psychiatry

188

105

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Objective: To review the nature of the presentation of neurosyphilis, the value of diagnostic tests, and the classification of the disease. Methods: A retrospective review was carried out of the records of patients who had been identified as possible cases of neurosyphilis by a positive FTA-abs test in the CSF. The review extended over 10 years at a single hospital which served a population of mixed ancestry in a defined catchment area in the Western Cape province of South Africa. Patients were placed in predefined diagnostic categories, and clinical, radiological, and laboratory features were assessed. Results: 161 patients met diagnostic criteria for neurosyphilis: 82 presented with combinations of delirium and dementia and other neuropsychiatric conditions, and the remainder had typical presentations such as stroke (24), spinal cord disease (15), and seizures (14). The average age of presentation ranged from 35.9 to 42.6 years in the different categories of neurosyphilis. Of those followed up, 77% had residual deficits from their initial illness. Cerebrospinal fluid (CSF) VDRL was positive in 73% of cases. Conclusions: The diagnosis of neurosyphilis can be made with reasonable certainty if there is an appropriate neuropsychiatric syndrome associated with a positive CSF VDRL. If the VDRL is negative, a positive FTA-abs in an appropriate clinical setting, associated with raised CSF cell count, protein, or IgG index, is a useful method of identifying neurosyphilis. Tabes dorsalis has become uncommon, but this is likely to be the only manifestation of neurosyphilis that has been altered during the antibiotic era.

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Section: Methodsmentioning

confidence: 99%

Neurosyphilis in the modern era

Timmermans

Carr²

2004

Journal of Neurology, Neurosurgery & Psychiatry

188

105

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“…This may be a response to antigens released as a result of 4 7 We found IgM in the CSF, but its presence in the CSF of patients with late syphilis is a rare phenomenon; IgM was detected in only five patients. Bowszyc4 also found IgM in the CSF of only a few patients with neurosyphilis, in whom there was also a high concentration of IgG.…”

Section: Discussionmentioning

confidence: 57%

Immunoglobulins in the cerebrospinal fluid of patients with late syphilis.

Gibowski¹,

Machońko²

1981

Sexually Transmitted Infections

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The concentrations of immunoglobulins G, A, and M were measured in 62 samples of cerebrospinal fluid from 35 patients with asymptomatic neurosyphilis, 18 with symptomatic neurosyphilis, and nine with late syphilis of other organs. The most frequent and highest increase in IgG and IgA occurred in patients with symptomatic neurosyphilis. IgM was found in only five patients, but its presence, together with an increase in IgG and IgA concentrations, appears to indicate activity of the pathological process and a poor prognosis for the course of the disease.

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“…Leukocytosis (!25 WBCs/mm 3 ) and elevated protein content (>150 mg/dL in full-term infants and >170 mg/dL in preterm infants) in the CSF in an infant who exhibits any features suggestive of congenital syphilis should be regarded as supportive of the diagnosis. Specific treponemal tests should not be done using CSF in infants suspected to have congenital syphilis because the results cannot be interpreted properly [346][347][348]. Specific treponemal tests should not be done using CSF in infants suspected to have congenital syphilis because the results cannot be interpreted properly [346][347][348].…”

Section: Approach To Diagnosis Of Congenital Syphilismentioning

confidence: 99%