Syphilis

Kollmann, Tobias R.; Dobson, Simon

doi:10.1016/b978-1-4160-6400-8.00016-x

Cited by 11 publications

(16 citation statements)

References 361 publications

(449 reference statements)

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“…ANC should be initiated within the first 12 weeks of gestation, and the first screening test for syphilis must be performed as soon as possible in pregnancy. In populations with a high prevalence of syphilis, the screening test must be repeated at the beginning of the third trimester (28th week of gestation) and at delivery [ 15 - 16 ]. In some populations, the detection of syphilis only at delivery is quite common, mainly if the woman did not have a proper ANC.…”

Section: Reviewmentioning

confidence: 99%

“…Conversely, NTT may give false negative results due to the prozone reaction, in which high antibody titers saturate the antigen, interfering with the antigen-antibody complex formation. Currently, the prozone reaction is rare because laboratories prevent it by testing any sample using a dilution of at least 1:8 [ 16 , 20 - 23 ].…”

Section: Reviewmentioning

confidence: 99%

“…This is the usual dose recommended for pregnant women with primary, secondary, or early latent syphilis. For instance, the 2015 CDC guidelines [ 15 ] and the chapter by Kollman and Dobson in the 2016 edition of Remington and Klein’s book [ 16 ] state that the treatment of pregnant women should follow the usual recommendation for the specific stage of acquired syphilis. Nonetheless, these guidelines also warn that several specialists would rather give an additional dose to pregnant women.…”

Section: Reviewmentioning

confidence: 99%

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Current Perspectives on Prevention of Mother-to-Child Transmission of Syphilis

Lago¹

2016

Cureus

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This article aims to provide an update on the prevention of mother-to-child transmission of syphilis by drawing upon some important basic concepts and reviewing the most recent literature on the diagnosis and treatment of syphilis in pregnancy. New technologies, such as automated and point-of-care immunologic tests, are shifting some paradigms, which will certainly be further investigated in the forthcoming years. This is the time to carefully evaluate traditional as well as new strategies to prevent congenital syphilis. Adverse outcomes of mother-to-child transmission of syphilis can be prevented with antenatal screening and penicillin therapy, which proved to have an excellent cost-benefit ratio even in populations with a low prevalence of syphilis. However, syphilis epidemiology is influenced by socioeconomic and cultural factors, and major challenges are faced by poor and developing countries in which the severity of the problem is extremely alarming. On the other hand, the emergence of new technologies has raised doubts about the best algorithm to be used when proper laboratory resources are available. Conditions are quite heterogeneous across populations, and some procedures should not be generalized while there is no evidence that supports some changes and while in-depth studies about local conditions are not conducted. Official organizations need to be alert in order to avoid isolated decisions and ensure that evidence-based guidelines be used in the management of syphilis in pregnancy.

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Section: Reviewmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

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Current Perspectives on Prevention of Mother-to-Child Transmission of Syphilis

Lago¹

2016

Cureus

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“…In rare instances, pathogens may be transmitted during passage through the birth canal. If the expectant mother is untreated, there is a 3–20 % chance of a stillbirth, depending on disease stage; some infants are born prematurely (Recommendation 8).…”

Section: Diagnosismentioning

confidence: 99%

S2k guideline* “Diagnosis and therapy of syphilis”—short version

Schöfer

Weberschock

Bräuninger³

et al. 2015

J Deutsche Derma Gesell

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“…Selten werden die Erreger bei Passage der Geburtswe‐ge auf das Kind iibertragen. Bei ausbleibender Therapie der Schwangeren kommt es in Abhängigkeit vom Erkrankungs‐stadium der Mutter in 3–20% zur Totgeburt, bei den lebend geborenen Kindern handelt es sich zum Teil um Friihgebore‐ne (S.Empfehlung 8).…”

Section: Diagnostik Der Syphilis Bei Neugeborenenunclassified