STUDY OF ENZYMATIC ANTIOXIDANT MARKER & LIPID PEROXIDATION STATUS IN PATIENTS WITH OSTEOARTHRITIS

Abstract

BACKGROUND/AIMS: Osteoarthritis is an inflammatory & degenerative disorder of joints. The exact pro-oxidant & antioxidant status is not clear in osteoarthritis. Our aims were to estimate levels of the lipid peroxidation (in terms of MDA) & enzymatic antioxidant (in terms of superoxide dismutase) in serum of osteoarthritis patients & compare them with the levels in normal healthy controls. MATERIAL & METHODS: A study was performed at the department of biochemistry at Pd. Dr. D. Y. Patil medical college, Pimpri, Pune-18(M.S.) In 30 patients of osteoarthritis serum levels of enzymatic antioxidant Marker (SOD) & lipid peroxidation status (MDA) were estimated by spectrophotometry. Thirty healthy controls were also included in the study & serum levels of same parameters were also measured. STATISTICAL ANALYSIS: It was performed by using the student unpaired t test. RESULT: A serum level of enzymatic antioxidant marker (SOD) was increased in the patients than in the controls. The serum lipid peroxidation (MDA) level was increased in the patients than in the controls.

Photobiomodulation therapy in knee osteoarthritis reduces oxidative stress and inflammatory cytokines in rats

“…They respond to noxious stimuli with greater intensity, as well as to non‐harmful stimuli as painful (peripheral sensitization). The rise in the nociceptive input of the periphery increases the activity and excitability in the spinal cord, known as central sensitization …”

“…Oxidative stress reflects an imbalance between the presence of reactive oxygen species (ROS) and the antioxidant defense system, assuming an important role in the pathogenesis of OA . Particularly, ROS increase the lipid peroxidation and oxidation of proteins, with consequent formation of carbonyl groups . In the present study, MIA increased lipid peroxidation and animals treated with PBM had lower levels of lipid peroxidation in blood serum (Laser 6 J group) and spinal cord (both laser groups).…”