Study of Dickkopf-1 (DKK-1) in patients with chronic viral hepatitis C-related liver cirrhosis with and without hepatocellular carcinoma

Eldeeb, Mona Kamal; Magour, Gehan Mahmoud; Bedair, Rania Nabil; Hammouda, Mennatallah Abdelfattah

doi:10.5114/ceh.2020.95831

Cited by 9 publications

(6 citation statements)

References 32 publications

(37 reference statements)

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“…Although no differences in DKK1 methylation was noted between the different conditions, there was a progressive increase in SFRP2 promoter methylation with normal liver < chronic hepatitis < liver cirrhosis < HCC (Umer et al, 2014). These findings are consistent with those of Eldeeb et al (2020) which showed that in HCV-infected patients with liver cirrhosis, with or without corresponding HCC, DKK1 expression was significantly decreased. Thus, evaluating promoter methylation status, especially for SFRP2, or DKK1 protein levels may prove to be useful for monitoring disease progression following HCV infection (Figure 4C).…”

Section: Oncogenic Viruses Subvert Wnt Signaling Through Multiple Mechanismssupporting

confidence: 88%

When Viruses Cross Developmental Pathways

Trivedi

Patel

Bellavia

et al. 2021

Front. Cell Dev. Biol.

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Aberrant regulation of developmental pathways plays a key role in tumorigenesis. Tumor cells differ from normal cells in their sustained proliferation, replicative immortality, resistance to cell death and growth inhibition, angiogenesis, and metastatic behavior. Often they acquire these features as a consequence of dysregulated Hedgehog, Notch, or WNT signaling pathways. Human tumor viruses affect the cancer cell hallmarks by encoding oncogenic proteins, and/or by modifying the microenvironment, as well as by conveying genomic instability to accelerate cancer development. In addition, viral immune evasion mechanisms may compromise developmental pathways to accelerate tumor growth. Viruses achieve this by influencing both coding and non-coding gene regulatory pathways. Elucidating how oncogenic viruses intersect with and modulate developmental pathways is crucial to understanding viral tumorigenesis. Many currently available antiviral therapies target viral lytic cycle replication but with low efficacy and severe side effects. A greater understanding of the cross-signaling between oncogenic viruses and developmental pathways will improve the efficacy of next-generation inhibitors and pave the way to more targeted antiviral therapies.

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Section: Oncogenic Viruses Subvert Wnt Signaling Through Multiple Mechanismssupporting

confidence: 88%

When Viruses Cross Developmental Pathways

Trivedi

Patel

Bellavia

et al. 2021

Front. Cell Dev. Biol.

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“…In the HCC group, there was a substantial reduction in albumin levels relative to the HCV group. This was agreed with [10]; who reported a mean albumin level of 4.55, 4.51, and 4.01 g / dl, respectively in the control group, HBV and HCC group, and [8]; who reported that the albumin level in the HCV group was slightly lower than in the control group. In addition, these findings were comparable to those of [1] and [5].…”

Section: Table (2)supporting

confidence: 87%

“…Compared with the HCV community, there were substantial increases in total and direct bilirubin and ALP in the HCC group. These were in line with [7], [8] and [9];…”

Section: Table (2)supporting

confidence: 76%

Comparative Study of SIRT1 Expression in Hepatitis B Virus, Hepatitis C Virus, and Hepatocellular Carcinoma Patients

Ibrahim

Rashed

Ghaly

et al. 2022

Egyptian Journal of Medical Research

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Background and Aim:The most common form of primary liver cancer in adults is hepatocellular carcinoma (HCC), and it is the most common cause of death in people with cirrhosis. The mammalian Sir2 family or sirtuins is formed of a cluster of highly conserved proteins triggering nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylase activity which target histone and non-histone substrates including enzymes, transcription regulators, tumor suppressors, cell signaling proteins and DNA repair proteins. Seven human sirtuins have been identified and named SIRT1-7. SIRT1 has been regarded as a tumor promoter due to its increased expression in some types of cancers and its role in the inactivation of proteins involved in tumor suppression and DNA damage repair. We aimed to estimate the level of SIRT-1 in the blood of HBV, HCV, and HCC patients, to investigate the possible role of SIRT-1 in the pathogenesis of HCC and to determine the role of SIRT-1 as a tumor marker or pomoter compared to other markers like α-feto protein. Subjects and Methods: This study was performed in Internal Medicine department Beni-Suef Hospital. Our study included 160 individuals; divided into four groups; group A (healthy control), group B (HBV patients), group C (HCV patients) and group D (HCC patients). The serum level of SIRT-1 was assessed and compared in all groups and correlate its level as a tumor marker with the other marker α-fetoprotein. Results: There was significant increase in SIRT-1 levels in HBV, HCV and HCC group as compared to control (p value <0.001). There was significant increase in SIRT-1 in HCV and HCC groups as compared to HBV group (p value <0.001). There was significant increase in SIRT-1 levels in HCC group as compared to HCV group (p value <0.001). There was positive correlation between α -feto protein and SIRT-1in HCC group only but no correlation in others groups. Conclusion:Our study demonstrated that SIRT-1 is overexpressed in HCC patients compared to

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“…With the progress of medical diagnosis technology, the advantages of serum tumor markers with high specificity and sensitivity and convenient detection in the differential diagnosis of GC have become the focus of clinical study [8]. Some studies [14] have confirmed that the combined detection of serum CA724 and CA19-9 has high specificity and sensitivity in the diagnosis of gastric stromal tumor, and studies have also reported [15] that serum DKK1 has an obviously high expression in patients with primary liver cancer. However, the sensitivity and specificity of detection with single indicator are low, which cannot meet the clinical needs due to the diversity and complexity of biological characteristics in tumor cells [16,17].…”

Section: Discussionmentioning

confidence: 99%

Clinical Value on Combined Detection of Serum CA724, DKK1, and TK1 in Diagnosis of Gastric Cancer

Wang

Cui

et al. 2022

Journal of Oncology

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Objective. To explore the clinical value on combined detection of serum carbohydrate antigen 724 (CA724), secreted protein dickkopf-1 (DKK1), and thymidine kinase 1 (TK1) in the diagnosis of gastric cancer (GC). Methods. The clinical data of 63 GC patients (GC group) and 54 patients with benign gastric lesions (control group) admitted to Zhu Xianyi Memorial Hospital of Tianjin Medical University from June 2020 to June 2021 were retrospectively analyzed. The levels of serum CA724, DKK1, and TK1 in the two groups were detected by electrochemiluminescence instrument, enzyme-linked immunosorbent assay, and enhanced chemiluminescence. The diagnostic efficacy of single detection and combined detection was analyzed by drawing the receiver operating characteristic (ROC) curve. Results. Compared with the control group, the serological indexes of patients in GC group were markedly higher ( P < 0.001 ). ROC curve analysis showed that the areas under the curve of serum CA724, DKK1, TK1, and combined detection in the diagnosis of GC were 0.849, 0.754, 0.685, and 0.923, respectively; and the sensitivity and specificity of their combined detection were higher than those of separate detection. Conclusion. The levels of serum CA724, DKK1, and TK1 were highly expressed in GC patients, with a higher diagnostic value for GC in their combined detection, which can effectively screen and assist the diagnosis of GC.

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Study of Dickkopf-1 (DKK-1) in patients with chronic viral hepatitis C-related liver cirrhosis with and without hepatocellular carcinoma

Cited by 9 publications

References 32 publications

When Viruses Cross Developmental Pathways

When Viruses Cross Developmental Pathways

Comparative Study of SIRT1 Expression in Hepatitis B Virus, Hepatitis C Virus, and Hepatocellular Carcinoma Patients

Clinical Value on Combined Detection of Serum CA724, DKK1, and TK1 in Diagnosis of Gastric Cancer

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