Study of dehydration and water states in new and worn soft contact lens materials

Krysztofiak, Katarzyna; Szyczewski, A.

doi:10.5277/oa140206

Cited by 5 publications

(2 citation statements)

References 28 publications

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“…Although the in vitro contact lens dehydration profile is not directly correlated to in vivo dryness and discomfort, , it might give information about material properties that might further affect lens performance . Designing contact lens materials capable of maintaining a well-hydrated surface would contribute to improved surface wettability, lubricity, and tear film stability, preventing ocular dryness and end-of-day discomfort…”

Section: Discussionmentioning

confidence: 99%

Investigating the Synergistic Interactions of Surface Immobilized and Free Natural Ocular Lubricants for Contact Lens Applications: A Comparative Study between Hyaluronic Acid and Proteoglycan 4 (Lubricin)

et al. 2021

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The main reasons for the discontinuation of contact lens wear are ocular dryness and discomfort. Proteoglycan 4 (PRG4), a mucinous glycoprotein, and hyaluronic acid (HA), a nonsulfated linear glycosaminoglycan, are naturally present in the eye and contribute to ocular hydration and lubrication. This study aimed to investigate the impact of the structure of the recombinant human PRG4 (rhPRG4)/HA complex on contact lens properties, when one agent is grafted and the counterpart is physisorbed on the surface of model conventional or silicone contact lens materials. Investigation of the wettability, water retention, antifouling, and boundary lubricant properties of the prepared hydrogels showed that the rhPRG4/HA interactions varied with the rhPRG/HA configuration on the hydrogel surface as well as the composition of the underlying substrate used. The rhPRG4-physisorbed/HA-grafted sample was characterized by better antifouling and boundary lubricant properties on the model conventional hydrogels, while the HA-physisorbed/rhPRG4-grafted sample exhibited improved surface wettability, antifouling, and water-retentive properties on the model silicone hydrogels. The results of this study contribute to the design of biomimetic contact lens surfaces that work synergistically with ocular fluid-phase biological agents to enhance compatibility between the contact lens and the ocular environment, alleviating dry eye symptoms and improving comfort.

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Section: Discussionmentioning

confidence: 99%

Investigating the Synergistic Interactions of Surface Immobilized and Free Natural Ocular Lubricants for Contact Lens Applications: A Comparative Study between Hyaluronic Acid and Proteoglycan 4 (Lubricin)

et al. 2021

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“…In soft CLs, the water content ranges from 38 to 75 % that has been approved by the FDA. The most common ways of measuring WC of soft lenses are by refractometry or gravimetry [17,18]. The contact lenses is strongly influenced by dehydration and this can induce changes in oxygen permeability (Dk), oxygen transmissibility (Dk/t), surface wettability or other lens parameter Differential scanning calorimetry, differential thermal analysis, sorption/desorption experiments Raman Spectroscopy, Near IR and ATR-FTIR spectroscopy have been used to better understand hydration properties of soft contact lenses [19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

ATR-FTIR, SAXS and UV-Vis Studies of Silicone Hydrogel and Bio-Hydrogel Soft Contact Lenses

Bayarı

Göcen²,

Bacıoğlu³

et al. 2022

AJACR

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Aims: This study aimed to evaluate the effect of contact lens materials on the structural properties and to examine ultraviolet (UVA part) and visible (Vis) transmittance with and without UV filters of the commercially available silicone hydrogel (SiHy) and bio-hydrogel (bio-Hy) soft contact lenses (CLs) in vitro. Place and Duration of Study: Hacettepe University, Department of Physics, Ankara, Turkey, between May 2018 and May 2021. Methodology:Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) spectra of CLs were recorded (at removing from its package, after 10 min, 1 h and 1 day at room temperature) in the 4000-650 cm-1region to estimate water contents of CLs. Hierarchical Cluster Analysis (HCA) was performed to differentiate chemical structure of CLs based on the spectral differences. Ultraviolet (UVA) and visible light transmittance of (CLs) was measured in the 315 -800 nm region. Small Angle X-ray Scattering (SAXS) analyses were performed to obtain further structural information on nano-scale. Results: One of the key observations in this study is the large influence of lens water content. The HCA analysis grouped all the CLs of same brand in same cluster based on their chemical similarity. The UVA transmittance results showed that CLs with UV blockers almost met ClassI and ClassII standards. The size (11.8-39.9 nm) and differences in morphologies of the nano globules were determined and correlated with equilibrium water content (EWC). Conclusion: This work was designed to explain important characteristics of commercial CLs and results will have implications for future experimental and clinical research regarding hydration/ dehydration experiments with CL polymers.

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Fouling in ocular devices: implications for drug delivery, bioactive surface immobilization, and biomaterial design

Uwaezuoke

Kumar

Pillay

et al. 2021

Drug Deliv. and Transl. Res.

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Study of dehydration and water states in new and worn soft contact lens materials

Cited by 5 publications

References 28 publications

Investigating the Synergistic Interactions of Surface Immobilized and Free Natural Ocular Lubricants for Contact Lens Applications: A Comparative Study between Hyaluronic Acid and Proteoglycan 4 (Lubricin)

Investigating the Synergistic Interactions of Surface Immobilized and Free Natural Ocular Lubricants for Contact Lens Applications: A Comparative Study between Hyaluronic Acid and Proteoglycan 4 (Lubricin)

ATR-FTIR, SAXS and UV-Vis Studies of Silicone Hydrogel and Bio-Hydrogel Soft Contact Lenses

Fouling in ocular devices: implications for drug delivery, bioactive surface immobilization, and biomaterial design

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