Study of correlation between serum vit-B12 and homocysteine levels with ischemic heart disease

Abstract

Background: Homocysteine is regarded as a risk factor for coronary artery disease, stroke, dementia and peripheral vascular disease. Present study aims to identify any correlation between serum vit-B12 and homocysteine levels in patients with ischemic heart disease at a tertiary hospital. Material and Methods: Present study was a prospective, observational study. Cases were selected among patients admitted to the Medicine Intensive Care unit, with symptoms of acute myocardial infarction with or without electrocardiographic signs of elevated ST segment. Age and BMI matched controls were selected from patients attending outpatient clinic, who had no history of cardiovascular disease or other chronic diseases such as renal failure. Results: Total 100 cases and 100 controls (age and BMI) matched controls were considered for present study. Risk factors to ischemic heart disease such as hypertension, diabetes melitus, smoking, sedentary lifestyle, family history for coronary disease and family history for hypertension were significantly more in cases as compared to controls and difference was statistically significant. We noted raised serum Homocysteine levels in cases as compared to controls, difference was statistically significant. Also serum vitamin B12 levels were less in cases as compared to controls, difference was statistically significant. Conclusion: We noted raised serum Homocysteine levels in cases as compared to controls, difference was statistically significant. Also serum vitamin B12 levels were less in cases as compared to controls, difference was statistically significant. vitamin B12 deficiency causing hyperhomocysteinemia may be a risk factor for cardiovascular disease and important for prediction of future cardiovascular disease.