Study of copper(II) ternary complexes with phosphocreatine and some polyamines in aqueous solution

Szyfman, Natalie Waissmann; Loureiro, Nina P.; Tenório, Thaís; Mercê, Ana Lúcia Ramalho; Mangrich, Antônio S.; Rey, Nicolás A.; Felcman, Judith

doi:10.1016/j.jinorgbio.2011.09.027

Cited by 8 publications

(3 citation statements)

References 24 publications

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“…Although the protonation constants as well as stability constants of copper and magnesium complexes can be found in literature, they were refined in this paper in the same experimental condition and are consistent with the literature data [30][31][32][33]. The values of successive protonation constants: logK 1 = 10.14, logK 2 = 4.94 determined for PCr from the computer analysis of titration data correspond to the protonation of the guanidine group and the second site at the phosphate group, respectively.…”

Section: Binary Systemssupporting

confidence: 80%

Heteronuclear complexes of phosphocreatine with copper(II) and magnesium(II) ions

2014

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It has been found that in the binary systems Mg(II)/phosphocreatine and Cu(II)/phosphocreatine at low pH, metal ions mainly coordinate via the phosphate group. At higher pH for copper(II) system, the efficiency of-PO 3 2group is low and coordination takes place via amine and carboxyl groups (Mg 2? is still coordinated to phosphate group). Differences in the coordination mode for copper and magnesium ions in binary systems at high pH suggested that it would be interesting to determine the mode of coordination in heteronuclear complexes and the coordination competitiveness of metal ions towards phosphate group at low and at physiological pH. The formation of heteronuclear complexes of phosphocreatine with Mg 2? and Cu 2? ions was investigated. The overall stability constants of these species were determined by the potentiometric studies and the coordination mode was concluded on the basis of several spectral investigations (EPR, Visible Spectroscopy, 2D 1 H-15 N NMR, 31 P NMR and FT-IR).

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Section: Binary Systemssupporting

confidence: 80%

Heteronuclear complexes of phosphocreatine with copper(II) and magnesium(II) ions

2014

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“…13 C NMR was used for the ligands and binary systems. 27 Al NMR was employed for the metal solution and binary systems.…”

Section: Nmr Spectroscopic Analysesmentioning

confidence: 99%

“…[13][14][15][16][17] Nevertheless, the study of aluminum(III) complexes in solution is very difficult, especially due to the coexistence of several species at the same pH and the formation of hydrolyzed byproducts, [15][16][17][18][19] since the aluminum ion is easily hydrolyzable. Amino acids can form complexes with aluminum(III) and retard its hydrolysis.…”

Section: Introductionmentioning

confidence: 99%

Multinuclear magnetic resonance study of equilibria between aluminum(III) and sulfur-containing amino acids in aqueous solutions

Tenório

2015

Journal of Sulfur Chemistry

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Aluminum(III) is generally found in small amounts in living organisms where it interacts with several biomolecules. Low mass biomolecules can form complexes associated with absorption and distribution processes of this toxic ion. However, investigating aluminum(III) complexes in solution poses singular difficulties, because it is highly hydrolyzable. Amino acids constitute possible ligands for aluminum(III). Methionine, cysteine and homocysteine are found in healthy human body. Penicillamine is a drug used in several circumstances, such as in treating metal poisoning. These four biomolecules share similar donor atoms involved in complexation reactions: a carboxylate oxygen, an amine nitrogen and sulfur. In this study, four binary complexes formed by aluminum(III) and amino acids in solution at a metalto-ligand ratio of 1:1 were analyzed through potentiometry and multinuclear magnetic resonance ( 13 C and 27 Al). Potentiometry data consistently demonstrated complexion formation. Distributions of species revealed the coexistence of several species in ample pH ranges and pointed out the preferable value to perform the NMR analyses. 13 C NMR data were used to confirm complexion formation, while 27 Al NMR data indicated the geometric arrangement adopted by the complexes. Structures were proposed for each complex.• Amino acids can form complexes related to the absorption and distribution of Al 3+ .• The techniques used were potentiometry, 13 C NMR and 27 Al NMR in solution.• The potentiometry reveals distribution of species according to pH of binary systems.• The 13 C NMR results indicate complexion formation.• The 27 Al NMR results indicate hexa-coordinated aluminum in the complex species.

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Creatine in Cell Metabolism and Its Protective Action in Cerebral Ischemia

Колпакова

Веселкина²,

Власов

2015

Neurosci Behav Physi

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Study of copper(II) ternary complexes with phosphocreatine and some polyamines in aqueous solution

Cited by 8 publications

References 24 publications

Heteronuclear complexes of phosphocreatine with copper(II) and magnesium(II) ions

Heteronuclear complexes of phosphocreatine with copper(II) and magnesium(II) ions

Multinuclear magnetic resonance study of equilibria between aluminum(III) and sulfur-containing amino acids in aqueous solutions

Creatine in Cell Metabolism and Its Protective Action in Cerebral Ischemia

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