Study of contrast-induced oxidative stress in nondiabetic patients undergoing coronary angiography

Manda, Prasanth; Rao, Pragna; Bitla, Aparna R.; Vinapamula, Kiranmayi S; Jeyaseelan, Lakshmanan; Rajasekhar, D.; Vishnubhotla, Sivakumar

doi:10.4103/1319-2442.252932

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“…These results are supported by previous studies, showing that MDA levels increased immediately after CM exposure. [46][47][48] Res/Lyc pre-treatment significantly decreased MDA levels in blood/renal tissue. These results indicate that both antioxidants had a positive effect due to their ability to protect mitochondrial/cell membranes from lipid peroxidation.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol and lycopene ameliorate contrast-induced nephropathy in a rabbit model

et al. 2022

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Oxidative stress appears to possess a central role in CIN pathophysiology. Resveratrol (Res) and lycopene (Lyc) are strong natural antioxidants evaluated in a limited number of CIN animal studies in vivo. The aim of the study was to evaluate the potential renoprotective effects of Res/Lyc in a CIN rabbit model. Twenty-four adult male New Zealand white rabbits were equally assigned into four groups: control (saline), CIN (intravenous iopromide; 7.5 g iodine/kg), Res + CIN (per os Res; 5 mg/kg), and Lyc + CIN (per os Lyc; 4 mg/kg). Serum Cr (sCr); symmetric/asymmetric dimethylarginine (SDMA/ADMA); oxidative stress biomarkers: malondialdehyde; total antioxidant capacity; catalase; glutathione) were evaluated in blood samples at three time points: right after (0 h); 24 h; 48 h after iopromide/saline administration. CD20+/CD3+ lymphocytes were determined (48 h). All animals were sacrificed at 48 h and both kidneys collected. Oxidative stress biomarkers were measured in renal tissue. sCr and SDMA/ADMA levels increased significantly in CIN compared to all groups. Oxidative stress secondary to CIN in blood/kidneys was suppressed by Res/Lyc. B and T lymphocytes decreased significantly in CIN compared to all groups. The present study provides emerging evidence that Res/Lyc ameliorate CIN by modulating oxidant/antioxidant balance in blood/renal tissue and by inhibiting vasoconstriction/blood cytotoxicity.

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Section: Discussionmentioning

confidence: 99%