Resveratrol and lycopene ameliorate contrast-induced nephropathy in a rabbit model

Abstract

Oxidative stress appears to possess a central role in CIN pathophysiology. Resveratrol (Res) and lycopene (Lyc) are strong natural antioxidants evaluated in a limited number of CIN animal studies in vivo. The aim of the study was to evaluate the potential renoprotective effects of Res/Lyc in a CIN rabbit model. Twenty-four adult male New Zealand white rabbits were equally assigned into four groups: control (saline), CIN (intravenous iopromide; 7.5 g iodine/kg), Res + CIN (per os Res; 5 mg/kg), and Lyc + CIN (per os Lyc; 4 mg/kg). Serum Cr (sCr); symmetric/asymmetric dimethylarginine (SDMA/ADMA); oxidative stress biomarkers: malondialdehyde; total antioxidant capacity; catalase; glutathione) were evaluated in blood samples at three time points: right after (0 h); 24 h; 48 h after iopromide/saline administration. CD20+/CD3+ lymphocytes were determined (48 h). All animals were sacrificed at 48 h and both kidneys collected. Oxidative stress biomarkers were measured in renal tissue. sCr and SDMA/ADMA levels increased significantly in CIN compared to all groups. Oxidative stress secondary to CIN in blood/kidneys was suppressed by Res/Lyc. B and T lymphocytes decreased significantly in CIN compared to all groups. The present study provides emerging evidence that Res/Lyc ameliorate CIN by modulating oxidant/antioxidant balance in blood/renal tissue and by inhibiting vasoconstriction/blood cytotoxicity.

Endogenous and Exogenous Antioxidants as Agents Preventing the Negative Effects of Contrast Media (Contrast-Induced Nephropathy)

“…Association of bilirubin level with CIN was found in [124,125,139]; induction of HO-1 (on animals) [140] Melatonin positive on animal models [146,149,[152][153][154][155] L-carnitine positive on humans [162][163][164][165] Statins positive on humans [170][171][172][173], meta-analyses [174][175][176][177], on animals [178,179] controversial on humans [180] Probucol positive on humans [181,182], meta-analyses [183,185] no results on humans, meta-analysis [184] MESNA positive on humans [190,192] Resveratrol positive on animal models [195,196], in vitro [197][198][199][200] Astaxanthin positive on animal models [204][205][206][207] Table 1. Cont.…”

“…Lycopene positive on animal models [200,[209][210][211] Green tea extract positive on animal models [219,220] GSPE positive on animal models [224,225] Curcumin positive on animal models [228,229] Xylose-pyrogallol conjugate positive on animal models [231]…”

“…The effects of resveratrol and lycopene (carotenoid) on CIN in rabbits were studied. It was shown that both resveratrol and lycopene ameliorated CIN by modulating oxidant/antioxidant balance in blood/renal tissue and by inhibiting vasoconstriction/blood cytotoxicity [ 200 ]. This medication needs further study.…”

“…The effects of lycopene and resveratrol on CIN in rabbits were studied (see above). It was found that both compounds attenuated CIN by modulating oxidant/antioxidant balance in blood/renal tissue and by inhibiting vasoconstriction/blood cytotoxicity [ 200 ].…”