Study of common variants of the apolipoprotein E and lipoprotein lipase genes in patients with coronary heart disease and variable body mass index

Abstract

OBJECTIVE:In the present study, we evaluated the influence of lipoprotein lipase (LPL) and apolipoprotein (apo) E polymorphisms on lipid concentrations of 178 Greek men of similar age with coronary heart disease (CHD), but varying body mass index (BMI). DESIGN: Patients were divided according to their BMI (in kg/m²) into three groups: lean (BMI=20-24.9), overweight (BMI=25-29.9), and obese (BMI ≥30). Polymorphisms of LPL (HindIII, S447X) and apo E (ε2, ε3, ε4), and lipid parameters were studied. RESULTS: There was a negative correlation between BMI and high-density lipoprotein cholesterol (HDL-C) concentration (r=-0.272, p<0.001), as has already been described. Lean homozygotes for the HindIII(+) allele had higher HDL-C levels compared to lean homozygotes for the HindIII(-) allele (p=0.012). No correlation was found between S447X or apo E polymorphisms and BMI or plasma lipids in any group. Overweight men with the ε3/ε3 and SS genotypes had higher triglycerides concentration compared with overweight men with ε3/ε3 and SX (p=0.002). CONCLUSIONS: The HindIII polymorphism alone may influence HDL-C concentration in lean men, in contrast to S447X alone, which has no influence on any lipid parameters. However, the S447X and apo E polymorphisms may have a synergetic effect and alter plasma triglyceride concentration in overweight men.

Lipid‐Related Genetic Variants for Personalized Dietary Interventions: A Systematic Review

“…Moreover, the rs320 (Hindlll) polymorphism was cross‐sectional associated with higher TG levels and lower HDL levels in the presence of visceral obesity. [ 23 ] Furthermore, the AA+AG genotype of the rs2197089 polymorphism was associated with decreased TG concentration. In this study, smoker participants with the minor allele A had a higher LPL activity and therefore increased HDL concentrations.…”

Logic Regression Analysis of Gene Polymorphisms and HDL Levels in a Nationally Representative Sample of Iranian Adolescents: The CASPIAN-III Study

“…It was reported that in Iranian children and adolescents, carriers of T allele of rs320 polymorphism are associated with lower TG and LDL-C and higher TC and HDL-C (24). Other studies showed that in healthy-weight men with coronary heart disease, the rs320 polymorphism alone might impress the HDL-C concentration, in contrast to rs328 alone, which has no influence on any lipid parameters (53).…”

Angiopoietin-like proteins - their role in lipoprotein metabolism and association with atherogenic dyslipidemia

“…Additionally, LPL is involved in the atherogenesis since it influences the interaction between atherogenic lipids and the surface of endothelial cells of arterial vessel walls [11]. Changes of LPL activity may occur in some pathophysiological processes related to obesity, diabetes, chylomicronemia and atherosclerosis [12].…”