Study of chitosan/xanthan gum polyelectrolyte complexes formation, solid state and influence on ibuprofen release kinetics

Ćirić, Ana; Medarević, Djordje; Čalija, Bojan; Dobričić, Vladimir; Mitrić, Miodrag; Djekić, Ljiljana

doi:10.1016/j.ijbiomac.2020.01.138

Cited by 52 publications

(56 citation statements)

References 55 publications

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“…At the starting time, the release process is controlled by the swelling capacity of the hydrogel while as the polymer networks become more hydrated, the release of IBU takes place through a diffusion process. This behavior was pointed out by other studies based on the evaluation of IBU release from different hydrogel matrix having in composition chitosan or other formulation typically designed for topical administration of ibuprofen [63]. Djekic et al showed that the maximum amount of IBU that can be released from a reference gel, namely Nurofen ® gel was approximately about 50% after 6 h [64].…”

Section: Evaluation Of Encapsulation Efficiency Drug Loading Capacitmentioning

confidence: 83%

One Step e-Beam Radiation Cross-Linking of Quaternary Hydrogels Dressings Based on Chitosan-Poly(Vinyl-Pyrrolidone)-Poly(Ethylene Glycol)-Poly(Acrylic Acid)

Călina

Demeter

Scărișoreanu

et al. 2020

IJMS

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We report on the successful preparation of wet dressings hydrogels based on Chitosan-Poly(N-Vinyl-Pyrrolidone)-Poly(ethylene glycol)-Poly(acrylic acid) and Poly(ethylene oxide) by e-beam cross-linking in weakly acidic media, to be used for rapid healing and pain release of infected skin wounds. The structure and compositions of hydrogels investigated according to sol-gel and swelling studies, network parameters, as well as FTIR and XPS analyses showed the efficient interaction of the hydrogel components upon irradiation, maintaining the bonding environment while the cross-linking degree increasing with the irradiation dose and the formation of a structure with the mesh size in the range 11–67 nm. Hydrogels with gel fraction above 85% and the best swelling properties in different pH solutions were obtained for hydrogels produced with 15 kGy. The hydrogels are stable in the simulated physiological condition of an infected wound and show appropriate moisture retention capability and the water vapor transmission rate up to 272.67 g m−2 day−1, to ensure fast healing. The hydrogels proved to have a significant loading capacity of ibuprofen (IBU), being able to incorporate a therapeutic dose for the treatment of severe pains. Simultaneously, IBU was released up to 25% in the first 2h, having a release maximum after 8 h.

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Section: Evaluation Of Encapsulation Efficiency Drug Loading Capacitmentioning

confidence: 83%

One Step e-Beam Radiation Cross-Linking of Quaternary Hydrogels Dressings Based on Chitosan-Poly(Vinyl-Pyrrolidone)-Poly(Ethylene Glycol)-Poly(Acrylic Acid)

Călina

Demeter

Scărișoreanu

et al. 2020

IJMS

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show abstract

“…At the starting time, the release process is controlled by the swelling capacity of the hydrogel while as the polymer networks become more hydrated, the release of IBU takes place through a diffusion process. This behavior was pointed out by other studies based on the evaluation of IBU release from different hydrogel matrix having in composition chitosan or other formulation typically designed for topical administration of ibuprofen [63]. Djekic et al showed that the maximum amount of IBU that can be released from a reference gel, namely Nurofen  gel was approximately about 50% after 6h [64].…”

Section: Material/bond Type C=o (C=o)-n C-o/c-n/c-o-c C-c/c-mentioning

confidence: 83%

One Step E-Beam Radiation Cross-Linking of Quaternary Hydrogels Dressings Based on Chitosan-Poly(Vinyl-Pyrrolidone)-Poly(ethylene Glycol)-Poly(Acrylic Acid)

Călina¹,

Demeter²,

Scărișoreanu³

et al. 2020

Preprint

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We report on the successful preparation of wet dressings hydrogels based on Chitosan-Poly(N-Vinyl-Pyrrolidone)-Poly(ethylene glycol)-Poly(acrylic acid) and Poly(ethylene oxide) by e-beam cross-linking in weakly acidic media, to be used for rapid healing and pain release of infected skin wounds. The structure and compositions of hydrogels investigated according to sol-gel and swelling studies, network parameters, as well as FTIR and XPS analyses showed the efficient interaction of the hydrogel components upon irradiation, maintaining the bonding environment while the cross-linking degree increasing with the irradiation dose and the formation of a structure with the mesh size in the range 11-67 nm. Hydrogels with gel fraction above 85% and the best-swelling properties in different pH solutions were obtained for hydrogels produced with 15 kGy. The hydrogels are stable in the simulated physiological condition of an infected wound and show appropriate moisture retention capability and the water vapor transmission rate up to 272.67 g m-2 day-1, to ensure fast healing. The hydrogels proved to have a significant loading capacity of ibuprofen (IBU), being able to incorporate a therapeutic dose for the treatment of severe pains. Simultaneously, IBU was released up to 25% in the first 2h, having a release maximum after 8h.

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“…The high molecular weight of chitosan also led to a higher swelling degree of beads (11,88). Very recently, Ćirić et al (12) studied the combined effect of pH adjusting agent type (hydrochloric, acetic or lactic acid) and pH value (3.6, 4.6 and 5.6) on the formation of chitosan/XG PECs, their characteristics and influence on in vitro ibuprofen release kinetics (Tab. I).…”

Section: Chitosan/xanthan Gum-based Pecsmentioning

confidence: 99%

“…It is important to stress that stoichiometric PECs always have an even amount of positive and negative charge, resulting in zero net charge, and their water solubility is poor. However, with the addition of one polymer in excess to the polymer mixture, the water-soluble non-stoichiometric PECs are formed (5,(10)(11)(12) (Fig. 1).…”

Section: Introductionmentioning

confidence: 99%

“…More recently, numerous PECs based on polysaccharides and proteins have been formulated as carriers for drug delivery, DNA delivery, or tissue engineering (2,4,7). Many different polyanions have been used for the formation of PECs with chitosan, such as natural polymers and their semi-synthetic derivatives (e.g., alginates (13)(14)(15)(16)(17)(18), pectin (19)(20)(21)(22)(23), xanthan gum (11,12,(24)(25)(26)(27), carrageenan (28)(29)(30), carboxymethylcellulose (31,32), collagen (25)), synthetic polymers and tripolyphosphate (TPP) (33) (Tab. I).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Biocompatible non-covalent complexes of chitosan and different polymers: Characteristics and application in drug delivery

Ćirić¹,

Krajišnik²,

Čalija³

et al. 2020

Arhiv za farmaciju

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The formulation of biocompatible drug carriers based on cationic biopolymer chitosan and natural or synthetic polymers represents an important research interest. Therefore, this review aims to perceive their potential in drug delivery. The most investigated chitosan-based polymer blends are polyelectrolyte complexes (PECs) obtained by establishing ionic interactions with biocompatible polyanions as alginates, pectin, xanthan gum, carrageenan, carboxymethylcellulose, and collagen. Depending on the preparation conditions, PECs could be prepared in versatile forms including membranes/films, hydrogel beads, nanoparticles, and microparticles, to achieve controlled (e.g., extended, delayed, colon-specific and pH-dependent) drug delivery. PECs can encapsulate hydrophilic and lipophilic drug substances with different molecular weights. Drug encapsulation allows the preservation of their structure, activity, improvement in absorption efficiency, reduction in adverse effects and long-term stability in vitro and in vivo. The biocompatible structures as non-covalent chitosan-based complexes could be formed also by establishing hydrogen bonds, for example with poly(vinyl alcohol). The swelling of these complexes is not pH-dependent and encapsulated drug substances are often released by already known types of diffusion. Moreover, grafted chitosan derivatives (e.g., carboxymethyl chitosan, trimethyl chitosan, acrylated chitosan) are synthesized to improve water solubility at a wide pH range and enhance the encapsulation capacity of promising PEC-based drug carriers.

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Study of chitosan/xanthan gum polyelectrolyte complexes formation, solid state and influence on ibuprofen release kinetics

Cited by 52 publications

References 55 publications

One Step e-Beam Radiation Cross-Linking of Quaternary Hydrogels Dressings Based on Chitosan-Poly(Vinyl-Pyrrolidone)-Poly(Ethylene Glycol)-Poly(Acrylic Acid)

One Step e-Beam Radiation Cross-Linking of Quaternary Hydrogels Dressings Based on Chitosan-Poly(Vinyl-Pyrrolidone)-Poly(Ethylene Glycol)-Poly(Acrylic Acid)

One Step E-Beam Radiation Cross-Linking of Quaternary Hydrogels Dressings Based on Chitosan-Poly(Vinyl-Pyrrolidone)-Poly(ethylene Glycol)-Poly(Acrylic Acid)

Biocompatible non-covalent complexes of chitosan and different polymers: Characteristics and application in drug delivery

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