One Step e-Beam Radiation Cross-Linking of Quaternary Hydrogels Dressings Based on Chitosan-Poly(Vinyl-Pyrrolidone)-Poly(Ethylene Glycol)-Poly(Acrylic Acid)

Abstract

We report on the successful preparation of wet dressings hydrogels based on Chitosan-Poly(N-Vinyl-Pyrrolidone)-Poly(ethylene glycol)-Poly(acrylic acid) and Poly(ethylene oxide) by e-beam cross-linking in weakly acidic media, to be used for rapid healing and pain release of infected skin wounds. The structure and compositions of hydrogels investigated according to sol-gel and swelling studies, network parameters, as well as FTIR and XPS analyses showed the efficient interaction of the hydrogel components upon irradiation, maintaining the bonding environment while the cross-linking degree increasing with the irradiation dose and the formation of a structure with the mesh size in the range 11–67 nm. Hydrogels with gel fraction above 85% and the best swelling properties in different pH solutions were obtained for hydrogels produced with 15 kGy. The hydrogels are stable in the simulated physiological condition of an infected wound and show appropriate moisture retention capability and the water vapor transmission rate up to 272.67 g m−2 day−1, to ensure fast healing. The hydrogels proved to have a significant loading capacity of ibuprofen (IBU), being able to incorporate a therapeutic dose for the treatment of severe pains. Simultaneously, IBU was released up to 25% in the first 2h, having a release maximum after 8 h.

Radiation Synthesis of Green Nanoarchitectonics of Guar Gum-Pectin/Polyacrylamide/Zinc Oxide Superabsorbent Hydrogel for Sustainable Agriculture

“…The gamma route fulfills several advantages such as clean simple technique, high-productivity, low energy, and low-cost process that leads to less contamination and fewer byproducts [21,22]. Radiation treatment can also introduce better surface crosslinking between natural and synthetic polymers by enhancing the formation of free macroradicals which finally lead to formation of crosslinked structure [23]. Moreover, the hydrogel composites were characterized via different techniques including infrared spectroscopy, Atomic force microscopy, and thermal analysis.…”

Water-Soluble Starch-Based Copolymers Synthesized by Electron Beam Irradiation: Physicochemical and Functional Characterization

“…The electron accelerator installation is of traveling-wave type, using microwaves in the S-band at 2.99 GHz that propagate in a disk-loaded tube of about 2 m long; the microwaves are produced by an EEV-M5125 type magnetron that provides 2 MW of power in pulses of 4 μs [ 38 ]. The ALID-7 accelerator is used in different experimental researches in the field of radiation [ 21 , 39 , 40 , 41 ]. The sample irradiations were carried out with different irradiation doses ( = 0.7–1.2 kGy) and dose rates ( = 0.5–0.7 kGy/min) as shown in Table 2 , at the room temperature (25 ± 1 °C) and ambient pressure under air.…”

Temperature Profile in Starch during Irradiation. Indirect Effects in Starch by Radiation-Induced Heating

“…The electron accelerator facility is of traveling-wave type which uses microwaves in the S-band at 2.99 GHz propagating in a disk-loaded tube of about 2 m long, and the microwaves are produced by an EEV-M5125 type magnetron delivering 2 MW of power in pulses of 4 μs [ 14 , 15 ]. The ALID-7 accelerator is used for various applied radiation researches [ 16 , 17 , 18 ]. The e-beam had a Gaussian-like profile of dose rate distribution, which was canceled at a distance of r = 37 mm from the beam axis at a distance of 220 mm from accelerator window exit.…”