Study of CCR5-59353C/T Polymorphism in the Iranian Patients With Chronic Hepatitis B Virus Infection

Abstract

Background: CCR5 is identified as one of the most important chemokine receptors with a major role in the creation of chemotaxis and mobilization of immunocompetent cells and moving them toward the liver for thorough cleaning of the virus. CCR5-59353 (C/T) is an important promoter polymorphism of chemokine receptor 5. Some studies showed a relationship between CCR5-59353 (C/T) polymorphism and clearance or persistence of hepatitis B virus (HBV) infection.