Study of bone marrow changes in antiretroviral naive human immunodeficiency virus-infected anemic patients

Pande, Arindam; Bhattacharyya, Maitree; Pain, Shantasil; Samanta, Ajanta

doi:10.4103/0377-4929.85089

Cited by 12 publications

(15 citation statements)

References 15 publications

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“…This is in concordance with study done by Pande et al (2011). [13] In the present study myelodysplasia was seen in bone marrow aspiration smears of 78% cases, this is in concordance with study by Karcher et al (1991) in which dysplasia is seen in 69% cases and Mittal et al (2014) in which dysplasia was seen in 76% cases. [2,14] It was found that some patients had shown dysplasia in bilineage as well as trilineage.…”

Section: Age and Sex Distributionsupporting

confidence: 92%

Bone Marrow Aspiration Findings in HIV Positive Patients and Correlation with CD4 Count.

Prabhjot¹,

Singh²,

Sibia³

et al. 2018

AIMDR

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Background: Bone marrow abnormalities are common in HIV infected individuals and patients with AIDS. Most of the bone marrow abnormalities associated with HIV infection appear to be related directly to the infection or its complications and not to therapeutic intervention. Bone marrow study is an important investigation in HIV infected patients with peripheral hematological abnormalities. The primary objective was to study bone marrow aspiration findings in HIV positive patients and their correlation with CD4 count. Methods: The interventional, crossectional and prospective study was conducted in Department of Pathology, Government Medical College and Rajindra Hospital Patiala on 100 HIV positive patients, during a period of 2 years. Hematological investigations including complete hemogram, peripheral blood film and bone marrow aspiration was done. Absolute CD4 counts were done. Correlation of various bone marrow abnormalities was done with CD4 count. Results: Bone marrow revealed normocellular marrow in majority of cases, followed by hypocellular. Overall prevalence of myelodysplasia was 78%. Dyserythropoiesis was most common dysplastic change (62%) followed by dysmegakaryopoies (36%), dysgranulopoiesis (25%). Reactive plasmacytosis was seen in 44% cases in the range from 6-20%. Increased lymphocytes seen in 9% cases. There was seen significant correlation between myelodysplasia and CD4 count. Conclusion: Bone marrow abnormalities are common in HIV infected individuals and patients with AIDS.So HIV infection should be considered in the differential diagnosis of patients with secondary myelodysplasia or unexplained bone marrow changes.

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Section: Age and Sex Distributionsupporting

confidence: 92%

Bone Marrow Aspiration Findings in HIV Positive Patients and Correlation with CD4 Count.

Prabhjot¹,

Singh²,

Sibia³

et al. 2018

AIMDR

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“…We found adequate stainable iron in majority of cases (60%), decreased in 24%, and increased in 16%. Our findings are in tune with most other studies 2,14 . Lack of concordance with few other studies 10,13 could be attributable to higher incidence of reticuloendothelial blockade in their patients which in turn can be due to advanced stage of infection at the time of presentation.…”

Section: Discussionsupporting

confidence: 80%

“…By 1984, HIV was clearly demonstrated to be the causative agent of AIDS 1 . India has an estimated 2.5 million HIV infection and worldwide approximately 2.7 million people are getting newly infected with this virus every year 2 . Hematological abnormalities are common in patients with HIV/AIDS.…”

Section: Introductionmentioning

confidence: 99%

Morphological study of bone marrow in HIV/AIDS patients with anaemia

Mittal

Kittur

Jadhav

et al. 2014

Int J of Biomed & Adv Res

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“…Although this finding was in stark contrast to most other studies of bone marrow morphology in HIV patients, which found no or limited dysplasia in the megakaryocytes 11,14,17 , Pande et al described similar rates and features of megakaryocytic dysplasia in their study of bone marrow changes in ARV-naïve anaemic patients. 18 Nuclear cytoplasmic asynchrony suggestive of megaloblastic changes was a prominent dyserythropoietic finding, with other studies 14,16,18 frequently reporting this finding. The most common feature of dysgranulopoiesis was abnormal nuclear segmentation (including pelgerised, ring, irregular forms and hypersegmentation) in both cohorts.…”

Section: Discussionmentioning

confidence: 51%

Retrospective comparison of cytological and histological bone marrow morphology in adult antiretroviral-naïve and antiretroviral experienced human immunodeficiency virus-infected patients with peripheral blood cytopaenias

Naidoo

Naicker

2016

Southern African Journal of Infectious Diseases

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A cohort of human immunodeficiency virus (HIV)-positive patients presenting to a quaternary hospital in KwaZulu-Natal, South Africa over a period of one year was identified and morphological analyses of their bone marrow aspirates and trephine biopsies (BMAT) undertaken. Aim: To compare and contrast the bone marrow morphological features of antiretroviral (ARV)-naïve and ARV-experienced HIV-positive population with cytopaenias; correlate the findings with CD4 counts; and, draw conclusions on whether ARV are associated with specific bone marrow (BM) findings. Method: Aspirate and trephine biopsy examinations to assess dysplasia of cell lineages, architectural changes, granulomas or infiltrates were performed by light microscopy. Results: 74 BMAT were examined, of which 24 were from the ARV-naïve cohort and 50 from ARV-treated cohort. Within granulomas, higher rates of marrow infiltration by acid-fast bacilli was present in the ARV-naïve cohort than the ARV-experienced cohort (6/10 (60%) versus 9/26 (35%), respectively). Higher rates of pure red cell aplasia (PRCA) were detected in the ARV-experienced than the ARV-naive cohort (14% versus 4%, respectively). No difference was seen in morphological features and overall dysplasia rates (70% and 71% of ARV-naïve and ARV-experienced cohort, respectively). At CD4 > 200 cells/ul, higher rates of dysplasia were seen in the ARV-naïve cohort (3/3 (100%) than in the ARV-experienced cohort (13/20 (65%)). Conclusion: Similar dysplasia rates and morphological features in both cohorts suggest ARVs do not cause myelodysplasia. BM tuberculosis is more frequently detected in granulomas of ARV-naïve than ARV-experienced samples. ARVs are implicated in causation of PRCA.

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Study of bone marrow changes in antiretroviral naive human immunodeficiency virus-infected anemic patients

Abstract: Bone marrow changes are common in Indian HIV-infected anemic population, particularly in the advanced stages of the disease. HIV infection should be considered in the differential diagnosis of patients with secondary myelodysplasia or unexplained bone marrow changes.

Cited by 12 publications

References 15 publications

Bone Marrow Aspiration Findings in HIV Positive Patients and Correlation with CD4 Count.

Bone Marrow Aspiration Findings in HIV Positive Patients and Correlation with CD4 Count.

Morphological study of bone marrow in HIV/AIDS patients with anaemia

Retrospective comparison of cytological and histological bone marrow morphology in adult antiretroviral-naïve and antiretroviral experienced human immunodeficiency virus-infected patients with peripheral blood cytopaenias

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