Morphological study of bone marrow in HIV/AIDS patients with anaemia

Mittal, Shilpa Taneja; Kittur, Shreekant K; Jadhav, Meena N; Mangal, Praveen

doi:10.7439/ijbar.v5i10.884

Cited by 1 publication

(3 citation statements)

References 8 publications

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“…These findings were in concordance with study done by Parinitha et al in (2012), [8] study by Kotwal et al in 2013 and study by Rehman et al in 2014. [9,10] Tripathi et al [11] (2005) 74.55% 78.95% 7.27% 5.26% 18.18% 15.79% Dhruve et al [12] (2013) 79.68% 79.06% 12.15% 13.95% 7.8% 6.97% Present study 58.6 % 66.7% 27.6% 16.7% 13.8% 16.7% [2] (1991) 69% 56% 18% 31% Mittal et al [14] (2014) 76% 68% 24% 36% Present study 78% 62 % 25% 36 %…”

Section: Age and Sex Distributionmentioning

confidence: 87%

“…[13] In the present study myelodysplasia was seen in bone marrow aspiration smears of 78% cases, this is in concordance with study by Karcher et al (1991) in which dysplasia is seen in 69% cases and Mittal et al (2014) in which dysplasia was seen in 76% cases. [2,14] It was found that some patients had shown dysplasia in bilineage as well as trilineage. Most common series affected was erthroid series.…”

Section: Age and Sex Distributionmentioning

confidence: 99%

“…Erythroid dysplasia was seen in 62% followed by megakaryocytic dysplasia, seen in 36% cases and granulocytic dysplasia was seen in 25% cases, this is similar with studies done by Karcher et al (1991) showing erythroid, megakaryocytic and granulocytic dysplasia in decreasing order (56%, 31%and 18%respectively). [2] Mittal et al (2014) observed that erythroid dysplasia was most common (68%), [14] followed by megakaryocytic dysplasia (36%) and granulocytic series (24%).…”

Section: Age and Sex Distributionmentioning

confidence: 99%

See 2 more Smart Citations

Bone Marrow Aspiration Findings in HIV Positive Patients and Correlation with CD4 Count.

Prabhjot¹,

Singh²,

Sibia³

et al. 2018

AIMDR

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Background: Bone marrow abnormalities are common in HIV infected individuals and patients with AIDS. Most of the bone marrow abnormalities associated with HIV infection appear to be related directly to the infection or its complications and not to therapeutic intervention. Bone marrow study is an important investigation in HIV infected patients with peripheral hematological abnormalities. The primary objective was to study bone marrow aspiration findings in HIV positive patients and their correlation with CD4 count. Methods: The interventional, crossectional and prospective study was conducted in Department of Pathology, Government Medical College and Rajindra Hospital Patiala on 100 HIV positive patients, during a period of 2 years. Hematological investigations including complete hemogram, peripheral blood film and bone marrow aspiration was done. Absolute CD4 counts were done. Correlation of various bone marrow abnormalities was done with CD4 count. Results: Bone marrow revealed normocellular marrow in majority of cases, followed by hypocellular. Overall prevalence of myelodysplasia was 78%. Dyserythropoiesis was most common dysplastic change (62%) followed by dysmegakaryopoies (36%), dysgranulopoiesis (25%). Reactive plasmacytosis was seen in 44% cases in the range from 6-20%. Increased lymphocytes seen in 9% cases. There was seen significant correlation between myelodysplasia and CD4 count. Conclusion: Bone marrow abnormalities are common in HIV infected individuals and patients with AIDS.So HIV infection should be considered in the differential diagnosis of patients with secondary myelodysplasia or unexplained bone marrow changes.

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