Study of bone marrow cells in non-Hodgkin's lymphoma by DNA analysis

Chen, Po Min; Fan, Sheng; Lin, S. H.; Tzeng, Cheng Hwai; Liu, Jin Hwang; Liu, Jacqueline M.; Yeh, Hsin mei; Chiou, Tzeon Jye

doi:10.1016/0145-2126(91)90177-u

Cited by 2 publications

(6 citation statements)

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“…This phe nomenon was also found in some of the acute leukemia patients (data not shown) here and in other reports [34][35][36], However, to present knowledge, only a handful of papers have described such coexistence of rearrangements of both Ig and TCR(i genes in CLL [37][38][39] or CLL with Richter's syndrome [40]. This phenomenon in B cell lym phoma has been previously reported by us [41] and other investigators [42]; the finding was considered to be a phe nomenon of a complex cross-lineage rearrangement in a B cell lymphoma. This may suggest a malignancy derived from an early, noncommitted lymphoid progenitor in a variety of lymphoproliferative disorders [41,42], As shown in table 3, the absolute immunophenotypic pattern supports this hypothesis of complex cross-lineage rear rangement, rather than the biclonal T and B theory raised in Richter's syndrome [40].…”

Section: Discussionmentioning

confidence: 57%

“…This phenomenon in B cell lym phoma has been previously reported by us [41] and other investigators [42]; the finding was considered to be a phe nomenon of a complex cross-lineage rearrangement in a B cell lymphoma. This may suggest a malignancy derived from an early, noncommitted lymphoid progenitor in a variety of lymphoproliferative disorders [41,42], As shown in table 3, the absolute immunophenotypic pattern supports this hypothesis of complex cross-lineage rear rangement, rather than the biclonal T and B theory raised in Richter's syndrome [40].…”

Section: Discussionmentioning

confidence: 74%

“…The second case, on the other hand, seemed to have a more indolent clini cal course with a 15-month follow-up. In addition, despite a higher incidence of T cell, non-Hodgkin's lymphoma in Taiwan [41], the incidence of T-CLL has been low.…”

Section: Discussionmentioning

confidence: 99%

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Genotypic Characterization and Multivariate Survival Analysis of Chronic Lymphocytic Leukemia in Taiwan

Chen

Lin²,

Fan³

et al. 1997

Acta Haematol

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In Taiwan, as in other areas of Asia, the incidence of chronic lymphocytic leukemia (CLL) is low. A retrospective analysis was conducted to elucidate the clinicopathologic features of CLL patients in Taiwan. Of the 47 cases of CLL enrolled in this study, 45 were immunophenotyped as B-CLL; the other 2 were T-CLL. It was found that the lower the Binet and Rai stages of the B-CLL, the longer patients survive (p = 0.0131 and 0.0142, respectively). Univariate analysis showed that fatigue, splenomegaly, hepatomegaly and anemia are associated with poor survival with p values of 0.0203, 0.0184, 0.0001 and 0.0171, respectively. By multivariate analysis with Cox’s proportional hazard model, hepatomegaly and decrease in body weight were the two most significant predictors of survival. However, molecular parameters of ĸ or λ immunoglobulin (Ig) gene rearrangement or double allele rearrangement of Ig gene did not significantly increase the predictability of the prognosis.

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 74%

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Genotypic Characterization and Multivariate Survival Analysis of Chronic Lymphocytic Leukemia in Taiwan

Chen

Lin²,

Fan³

et al. 1997

Acta Haematol

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“…Such analysis of BM aspiration cells showed good concordance with the morphology as well as increased sensitivity and specificity 16, 17. Patients with evidence of BM involvement by SB without morphologic evidence showed significantly shorter disease free survival 17. But several disadvantages, such as the amount of time and labor needed, the requirement of large quantities of DNA, the reliance on the radioactive probes, and the relative insensitivity, made SB analysis unfavorable for routine diagnostic testing 18, 19.…”

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confidence: 97%

“…Molecular testing initially employed Southern blot (SB) analysis to detect these rearrangements 15. Such analysis of BM aspiration cells showed good concordance with the morphology as well as increased sensitivity and specificity 16, 17. Patients with evidence of BM involvement by SB without morphologic evidence showed significantly shorter disease free survival 17.…”

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confidence: 99%

Polymerase chain reaction‐based diagnosis of bone marrow involvement in 170 cases of non‐Hodgkin lymphoma

Kang

Park

Seo

et al. 2002

Cancer

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BACKGROUND Up to the current time, diagnosis of bone marrow (BM) involvement in non‐Hodgkin lymphoma (NHL) has been based on morphologic findings. Polymerase chain reaction (PCR) for antigen receptor gene rearrangements has the potential to increase the detection sensitivity of minimal degrees of BM involvement. The authors therefore assessed PCR‐based clonalities of BM concurrently with morphology from 170 cases with NHL and evaluated the usefulness of comparative analysis of clonalities between bilateral BMs and the lymph node and the clinical significance of PCR based clonalities of BM. METHODS Bilateral BM clot sections of 170 cases and 47 lymph nodes were tested for immunoglobulin heavy chain gene rearrangement or T‐cell receptor gamma gene rearrangement according to the B‐ or T‐lineage of the lymph node. RESULTS When compared with morphology, the results of PCR showed an unexpectedly low positive concordance rate of 61.0% for B‐cell NHL and 57.1% for T‐cell NHL. When the clonality of BM was compared with that of lymph nodes in B‐cell NHL, bilateral clonalities of BM showed high concordance with the clonality of the lymph nodes. PCR‐based clonality did not show significant impact on survival. CONCLUSIONS Morphology remains the gold standard in the evaluation of BM involvement by NHL. Although the comparative analysis of BM clonality and that of the lymph nodes is considered a valuable tool that increases the reliability of clonality, PCR‐based clonality of BM does not significantly add to the sensitivity of diagnosing BM involvement by NHL. Cancer 2002;94:3073–82. © 2002 American Cancer Society. DOI 10.1002/cncr.10584

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Study of bone marrow cells in non-Hodgkin's lymphoma by DNA analysis

Cited by 2 publications

References 36 publications

Genotypic Characterization and Multivariate Survival Analysis of Chronic Lymphocytic Leukemia in Taiwan

Genotypic Characterization and Multivariate Survival Analysis of Chronic Lymphocytic Leukemia in Taiwan

Polymerase chain reaction‐based diagnosis of bone marrow involvement in 170 cases of non‐Hodgkin lymphoma

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