1991
DOI: 10.1016/0145-2126(91)90177-u
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Study of bone marrow cells in non-Hodgkin's lymphoma by DNA analysis

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Cited by 2 publications
(6 citation statements)
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“…This phe nomenon was also found in some of the acute leukemia patients (data not shown) here and in other reports [34][35][36], However, to present knowledge, only a handful of papers have described such coexistence of rearrangements of both Ig and TCR(i genes in CLL [37][38][39] or CLL with Richter's syndrome [40]. This phenomenon in B cell lym phoma has been previously reported by us [41] and other investigators [42]; the finding was considered to be a phe nomenon of a complex cross-lineage rearrangement in a B cell lymphoma. This may suggest a malignancy derived from an early, noncommitted lymphoid progenitor in a variety of lymphoproliferative disorders [41,42], As shown in table 3, the absolute immunophenotypic pattern supports this hypothesis of complex cross-lineage rear rangement, rather than the biclonal T and B theory raised in Richter's syndrome [40].…”
Section: Discussionmentioning
confidence: 57%
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“…This phe nomenon was also found in some of the acute leukemia patients (data not shown) here and in other reports [34][35][36], However, to present knowledge, only a handful of papers have described such coexistence of rearrangements of both Ig and TCR(i genes in CLL [37][38][39] or CLL with Richter's syndrome [40]. This phenomenon in B cell lym phoma has been previously reported by us [41] and other investigators [42]; the finding was considered to be a phe nomenon of a complex cross-lineage rearrangement in a B cell lymphoma. This may suggest a malignancy derived from an early, noncommitted lymphoid progenitor in a variety of lymphoproliferative disorders [41,42], As shown in table 3, the absolute immunophenotypic pattern supports this hypothesis of complex cross-lineage rear rangement, rather than the biclonal T and B theory raised in Richter's syndrome [40].…”
Section: Discussionmentioning
confidence: 57%
“…This phenomenon in B cell lym phoma has been previously reported by us [41] and other investigators [42]; the finding was considered to be a phe nomenon of a complex cross-lineage rearrangement in a B cell lymphoma. This may suggest a malignancy derived from an early, noncommitted lymphoid progenitor in a variety of lymphoproliferative disorders [41,42], As shown in table 3, the absolute immunophenotypic pattern supports this hypothesis of complex cross-lineage rear rangement, rather than the biclonal T and B theory raised in Richter's syndrome [40].…”
Section: Discussionmentioning
confidence: 74%
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“…Such analysis of BM aspiration cells showed good concordance with the morphology as well as increased sensitivity and specificity 16, 17. Patients with evidence of BM involvement by SB without morphologic evidence showed significantly shorter disease free survival 17. But several disadvantages, such as the amount of time and labor needed, the requirement of large quantities of DNA, the reliance on the radioactive probes, and the relative insensitivity, made SB analysis unfavorable for routine diagnostic testing 18, 19.…”
mentioning
confidence: 97%
“…Molecular testing initially employed Southern blot (SB) analysis to detect these rearrangements 15. Such analysis of BM aspiration cells showed good concordance with the morphology as well as increased sensitivity and specificity 16, 17. Patients with evidence of BM involvement by SB without morphologic evidence showed significantly shorter disease free survival 17.…”
mentioning
confidence: 99%