Genotypic Characterization and Multivariate Survival Analysis of Chronic Lymphocytic Leukemia in Taiwan

Chen, Po‐Min; Lin, Siu-huie; Fan, Sheng; Chiou, Tzeon‐Jye; Hsieh, Ruey‐Kuen; Yu, I-Ting; Liu, Jin-hwang

doi:10.1159/000203683

Cited by 6 publications

(2 citation statements)

References 16 publications

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“…CLL is a typical malignancy that displays ethnic differences: Although it is one of the most common leukemia in Caucasians, it is extremely rare in Asian countries [1, 2]. While the incidence rate (per 100,000 person-years) of CLL is 3.83 in Caucasians [2], it is only 0.04 in Korea [3], 0.48 in Japan [4], 0.6 in Koreans residing in America, and 0.8 in Chinese residing in America [5].…”

Section: Introductionmentioning

confidence: 99%

Genomic Profile of Chronic Lymphocytic Leukemia in Korea Identified by Targeted Sequencing

et al. 2016

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Chronic lymphocytic leukemia (CLL) is extremely rare in Asian countries and there has been one report on genetic changes for 5 genes (TP53, SF3B1, NOTCH1, MYD88, and BIRC3) by Sanger sequencing in Chinese CLL. Yet studies of CLL in Asian countries using Next generation sequencing have not been reported. We aimed to characterize the genomic profiles of Korean CLL and to find out ethnic differences in somatic mutations with prognostic implications. We performed targeted sequencing for 87 gene panel using next-generation sequencing along with G-banding and fluorescent in situ hybridization (FISH) for chromosome 12, 13q14.3 deletion, 17p13 deletion, and 11q22 deletion. Overall, 36 out of 48 patients (75%) harbored at least one mutation and mean number of mutation per patient was 1.6 (range 0–6). Aberrant karyotypes were observed in 30.4% by G-banding and 66.7% by FISH. Most recurrent mutation (>10% frequency) was ATM (20.8%) followed by TP53 (14.6%), SF3B1 (10.4%), KLHL6 (8.3%), and BCOR (6.25%). Mutations of MYD88 was associated with moderate adverse prognosis by multiple comparisons (P = 0.055). Mutation frequencies of MYD88, SAMHD1, EGR2, DDX3X, ZMYM3, and MED12 showed similar incidence with Caucasians, while mutation frequencies of ATM, TP53, KLHL6, BCOR and CDKN2A tend to be higher in Koreans than in Caucasians. Especially, ATM mutation showed 1.5 fold higher incidence than Caucasians, while mutation frequencies of SF3B1, NOTCH1, CHD2 and POT1 tend to be lower in Koreans than in Caucasians. However, mutation frequencies between Caucasians and Koreans were not significantly different statistically, probably due to low number of patients. Collectively, mutational profile and adverse prognostic genes in Korean CLL were different from those of Caucasians, suggesting an ethnic difference, while profile of cytogenetic aberrations was similar to those of Caucasians.

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Section: Introductionmentioning

confidence: 99%

Genomic Profile of Chronic Lymphocytic Leukemia in Korea Identified by Targeted Sequencing

et al. 2016

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“…35 Like FL, however, the pathology, treatment response and disease course of Asian CLL cases are, however, no different. [36][37][38] Finally, in the few migrants studies published, a gradual but incomplete Westernization in disease pattern is seen in all groups of B cell lymphomas in Asian migrants to North American, suggesting short term environmental factors may play a significant role in the development of these diseases. 20,39 Several regional issues also need to be highlighted in B cell lymphoma in Asians.…”

Section: B Cell Non-hodgkin Lymphomamentioning

confidence: 96%

Lymphoma in Asia

Au¹

2004

Cancer Rev. A. P.

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The epidemiology of lymphoma varied greatly among different ethnic groups in the world. The incidence and spectrum of Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) in Asian countries is different from that in Western countries and varies within Asia itself. An increasing incidence in lymphoma reported from Caucasian data is also seen in Asia, albeit at a lower rate. Key features of lymphoma epidemiology in Oriental countries include a lower incidence of HL, follicular lymphoma and in particular chronic lymphocytic leukemia, but a higher incidence of extranodal lymphoma and T and NK lineage disease. This may be related to differences in social economic conditions, genetic susceptibility and infective agents. Treatment results in Asian lymphoma cases do not seem to differ from Western counterparts. The epidemiology pattern is, however, likely to change with improved living conditions, longer life expectancy, Westernized living habits and the HIV epidemic.

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Prognostic models for newly-diagnosed chronic lymphocytic leukaemia in adults: a systematic review and meta-analysis

Kreuzberger

Damen

Trivella

et al. 2020

Cochrane Database of Systematic Reviews

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Genotypic Characterization and Multivariate Survival Analysis of Chronic Lymphocytic Leukemia in Taiwan

Cited by 6 publications

References 16 publications

Genomic Profile of Chronic Lymphocytic Leukemia in Korea Identified by Targeted Sequencing

Genomic Profile of Chronic Lymphocytic Leukemia in Korea Identified by Targeted Sequencing

Lymphoma in Asia

Prognostic models for newly-diagnosed chronic lymphocytic leukaemia in adults: a systematic review and meta-analysis

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