Study of blood plasma optical properties in mice grafted with Ehrlich carcinoma in the frequency range 0.1–1.0 THz

Smolyanskaya, O. A.; Kravtsenyuk, Olga V.; Panchenko, Andrey; Odlyanitskiy, E. L.; Guillet, Jean-Paul; Черкасова, О. П.; Khodzitsky, Mikhail K.

doi:10.1070/qel16383

Cited by 16 publications

(3 citation statements)

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“…The spatial separation of exosome samples confirms this approach's potential for colorectal cancer detection through exosome analysis by THz spectroscopy. Studies of blood plasma have been performed [153][154][155] using transmittance spectra in the 0.05-1.0 THz spectral range of the blood serum of rats with Ehrlich carcinoma were compared with healthy ones, and a decrease in the protein content was established. The same approach was applied to rats with Fig.…”

Section: Terahertz Spectroscopymentioning

confidence: 99%

Types of spectroscopy and microscopy techniques for cancer diagnosis: a review

et al. 2022

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Cancer is a life-threatening disease that has claimed the lives of many people worldwide. With the current diagnostic methods, it is hard to determine cancer at an early stage, due to its versatile nature and lack of genomic biomarkers. The rapid development of biophotonics has emerged as a potential tool in cancer detection and diagnosis. Using the fluorescence, scattering, and absorption characteristics of cells and tissues, it is possible to detect cancer at an early stage. The diagnostic techniques addressed in this review are highly sensitive to the chemical and morphological changes in the cell and tissue during disease progression. These changes alter the fluorescence signal of the cell/tissue and are detected using spectroscopy and microscopy techniques including confocal and two-photon fluorescence (TPF). Further, second harmonic generation (SHG) microscopy reveals the morphological changes that occurred in non-centrosymmetric structures in the tissue, such as collagen. Again, Raman spectroscopy is a non-destructive method that provides a fingerprinting technique to differentiate benign and malignant tissue based on Raman signal. Photoacoustic microscopy and spectroscopy of tissue allow molecule-specific detection with high spatial resolution and penetration depth. In addition, terahertz spectroscopic studies reveal the variation of tissue water content during disease progression. In this review, we address the applications of spectroscopic and microscopic techniques for cancer detection based on the optical properties of the tissue. The discussed state-of-the-art techniques successfully determines malignancy to its rapid diagnosis.

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Section: Terahertz Spectroscopymentioning

confidence: 99%

Types of spectroscopy and microscopy techniques for cancer diagnosis: a review

et al. 2022

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“…Terahertz (THz) spectroscopy application for medical purposes is expanding rapidly due to its safety feature, growing number of global population and development of novel diagnostic technologies [1]- [2][3][4] [5]. Development of any THz biomedical devices requires phantoms for device testing and calibration.…”

Section: Introductionmentioning

confidence: 99%

“…Real biological tissues and organs are not suitable for this purpose because of instability of their properties, in particular, due to presence of water and its evaporation. Since THz radiation is very sensitive to water content [3]- [4], [5], this will significantly affect the measured signal. Therefore, waterfree phantoms are in high demand to substitute real biological tissues and should be developed.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Water-free Biotissue-mimicking Phantoms in Terahertz Frequency Range

Zhang

Khodzitsky

Demchenko

et al. 2018

2018 43rd International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz)

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PVC-based water-free phantoms with silicon and zinc oxide nanoparticles were fabricated for mimicking biotissues in the terahertz frequency range. Terahertz time-domain spectroscopy (TDS) was used to obtain the refractive indices and absorption coefficients of the phantoms. Their optical properties were compared with those of real biotissues from published data. The results show that the phantoms are able to mimic human skin, paraffin-embedded glioma and paraffin-embedded healthy brain tissue by their optical properties. The refractive index of the phantoms can be controlled by changing the concentration of the nanoparticles.

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